MEDIZINISCHE UNIVERSITAET INNSBRUCK

INNSBRUCK

Unclaimed

Subcontracting experience

1 record from government sources. Past participation is not evidence of current teaming interest.

Role	Agency	Description	Vehicle	Obligated	Action date	Period
Subcontractor	Department of Health and Human Services	OPTION 9A: 0258-A709-4612 THE AIM OF THE FIRST STUDY IS TO ISOLATE SARS-COV-2 VARIANTS DETECTED IN AUSTRIA. NEW ISOLATES WILL BE SEQUENCED USING WHOLE GENOME SEQUENCING AND REPRESENTATIVE ISOLATES CHARACTERIZED IN VITRO BY GROWTH KINETICS AND NEUTRALIZATION PROFILES USING A SELECTION OF SERA FROM CONVALESCENT AND/OR VACCINATED INDIVIDUALS. FOR THE SECOND STUDY, SERA FROM VACCINATED AND/OR CONVALESCENT INDIVIDUALS WILL BE COLLECTED. NEUTRALIZATION ASSAYS WILL BE PERFORMED AGAINST A PANEL OF SARS-COV-2 VARIANTS TO CHARACTERIZE THE NEUTRALIZATION PROFILE OF THE SERA. OPTION 9B: 0258-A730-4612 ISOLATION AND ANTIGENIC CHARACTERIZATION OF NEW VIRUS VARIANTS IN AUSTRIA THE OVERALL AIM OF THE PROJECT IS THE ANTIGENIC CHARACTERIZATION OF NEW SARS-COV-2 VARIANTS. POSITIVE SWAB AND GARGLE SAMPLES WILL BE SEQUENCED VIA OXFORD NANOPORE SEQUENCING. FOR INTERESTING VARIANTS, VIRUS WILL BE ISOLATED AND ANTIGENICALLY CHARACTERIZED USING A PANEL OF HUMAN FIRST INFECTION SERA. ANTIGENIC CHARTOGRAPHIE BASED ON HUMAN SERA IS LIMITED FOR NEWER VARIANTS AS HUMAN FIRST EXPOSURE SERA BEYOND THE EARLY OMICRON VARIANTS ARE RARE OR NOT AVAILABLE. THEREFORE, WE WILL COMPARE ANTIGENIC MAPS DERIVED FROM HUMAN OR ANIMAL SERA. ADDITIONALLY, NEUTRALIZATION PROFILES OF NEW VIRUS VARIANTS WILL BE ANALYZED IN SERA FROM INDIVIDUALS AFTER MORE COMPLEX EXPOSURE HISTORIES, E.G. BIVALENT BOOSTER IMMUNIZATION, HYBRID IMMUNITY, MULTIPLE INFECTIONS. 0258-A709-4612 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: NY Parent award description: MSSM CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE. View parent award on USAspending	—	$361,134	Dec 22, 2022	— – —

Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.