THE MORGRIDGE INSTITUTE FOR RESEARCH, INC.

MADISON, WI, 53715

Unclaimed

Subcontracting experience

1 record from government sources. Past participation is not evidence of current teaming interest.

Role	Agency	Description	Vehicle	Obligated	Action date	Period
Subcontractor	Department of Health and Human Services	THIS PROJECT WILL CREATE A REGENERATIVE MEDICINE THERAPY; PLURIPOTENT STEM CELL-DERIVED THYMIC EPITHELIAL CELLS (PSC-TE). WITH OUR COLLABORATORS AT THE UNIVERSITY OF CALGARY (EXPERTISE IN DERIVATION OF PSC CELL TYPES IN THE TE LINEAGE) AND THE MORGRIDGE INSTITUTE FOR RESEARCH (EXPERTISE IN DESIGN AND ANALYSIS OF SINGLE CELL RNA SEQUENCING STUDIES) WE WILL CREATE PSC-TE AND CONDUCT COMPARATIVE STUDIES WITH THE PRIMARY THYMUS TISSUE FROM THE DONORS USED TO MAKE PSC-TE. THESE STUDIES WILL GIVE US A UNIQUE OPPORTUNITY TO EVALUATE THE EFFICIENCY OF OUR PSC-TE PROTOCOLS BY COMPARING THE FIDELITY OF OUR REGENERATIVE MEDICINE THERAPY TO THE ACTUAL TISSUE FROM THE SAME DONOR THAT WE ARE TRYING TO REPLICATE. WE WILL PERFORM A SERIES OF TRANSPLANTATION EXPERIMENTS IN IMMUNE-DEFICIENT MOUSE STRAINS AS PART OF THIS PROJECT, WHICH WILL ALLOW US TO DETERMINE THE THERAPEUTIC POTENTIAL (I.E., ENGRAFTMENT AND FUNCTION) OF OUR PSC-TE. 0000003229 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: WI Parent award description: CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS) View parent award on USAspending	—	$49,434	Dec 11, 2023	— – —

Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.