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UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC
LAWRENCE, KS, 66045
Unclaimed
Prime contracting experience
10 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Transportation Federal Highway Administration | IMPROVED DETAILING IN STEEL BRIDGES TO PREVENT CONSTRAINT-INDUCED FRACTURE | — | $251,181 | Sep 29, 2026 | Sep 29, 2021 – Dec 29, 2025 |
| Prime | Department of Defense Department of the Army | BAA 24-0059 WITH THE KU - ADVANCING SEISMIC PROCESSING TECHNIQUES (FULL WAVEFORM INVERSION, ARTIFICIAL INTELLIGENCE, JOINT INVERSION) TO IMPROVE IDENTIFICATION, RESOLUTION, AND CHARACTERIZATION OF ANOMALIES IN DAMS AND LEVEES WITH FAILURE POTENTIAL | — | $300,930 | Jul 22, 2026 | Apr 10, 2025 – Apr 14, 2028 |
| Prime | Department of Defense Department of the Navy | THE EMERGENCE OF LOW-COST, SOFTWARE-DEFINED RF SYSTEMS COMBINED WITH ATTRITABLE AUTONOMOUS PLATFORMS HAS GREATLY COMPLEXIFIED USE OF THE ELECTROMAGNETIC (EM) SPECTRUM FOR DEFENSEAPPLICATIONS. | — | $288,930 | Jun 11, 2026 | Jun 11, 2026 – Jun 11, 2030 |
| Prime | Department of Defense Department of the Navy | THE PROPOSED EFFORT WILL LEVERAGE RECENT ADVANCES INVOLVING PHYSICALLY REALIZABLE WAVEFORMS AND ASSOCIATED RECEIVE PROCESSING TO FURTHER DEVELOP AND EXPERIMENTALLY DEMONSTRATE CUTTING-EDGE RADAR AND MULTIFUNCTION RF CAPABILITIES. THE WORK WILL MAKE U | — | $2,013,181 | May 27, 2026 | Jun 20, 2023 – Jan 15, 2027 |
| Prime | Department of Defense Department of the Navy | THE PROPOSED WORK WILL DEVELOP A SYSTEM INVERSION SCHEME TO RETURN CORRECTED COPIES OF SOIS AND INTERFERERS. | — | $250,000 | May 27, 2026 | May 27, 2026 – May 26, 2029 |
| Prime | Department of Defense Department of the Navy | NAVY APPLICATION OF PHYSICAL MIMO WAVEFORM DIVERSITY | — | $1,729,215 | Feb 17, 2026 | Feb 6, 2020 – Oct 25, 2023 |
| Prime | Department of Defense Department of the Army | BAA 21-0029, YEAR 1 - TASK 1-3 IMPROVING THE PERFORMANCE OF CONCRETE DAM INFRASTRUCTURE THROUGH USE OF FIBER-REINFORCED POLYMERS | — | $6,015,076 | Jan 28, 2026 | Mar 18, 2022 – Jan 26, 2027 |
| Prime | National Science Foundation National Science Foundation | BAA - TRACK K- WATER EQUITY | — | $650,000 | Feb 12, 2024 | Feb 12, 2024 – Feb 11, 2025 |
| Prime | Department of Defense Department of the Army | IGF::OT::IGF RESEARCH AND DEVELOPMENT RELATED TO THE ACTIVE SEISMIC IMAGING SYSTEM FOR THE ARMY CORPS OF ENGINEERS U438180 | — | $3,243,052 | Oct 31, 2023 | Mar 31, 2019 – Dec 19, 2024 |
| Prime | Department of Health and Human Services National Institutes of Health | IGF::OT::IGF ADJUVANT DISCOVERY PROGRAM | — | $9,731,461 | Mar 9, 2022 | Sep 23, 2014 – Sep 29, 2021 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
40 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK TO SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2026-8/31/2027). KU WILL ACCEPT PROTEIN AND OTHER SAMPLES PRIMARILY GENERATED BY OTHER SSGCID SITES AND PREPARE THEM FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES, CONDUCT CRYSTALLIZATION EXPERIMENTS, COLLECT DIFFRACTION DATA, AND PERFORM STRUCTURE SOLUTION. KU WILL ALSO SUPPORT VARIOUS SPECIAL PROJECT STUDIES AS NEEDED AND LEAD ONE FUNCTIONAL STUDY.
A. STRUCTURE DETERMINATION OF PROTEINS OR PROTEIN COMPLEXES BY X-RAY CRYSTALLOGRAPHY:
KU WILL ACCEPT PROTEIN SAMPLES PRIMARILY RECEIVED FROM THE OTHER TEAM SITES FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES AND CONDUCT HIGH THROUGHPUT CRYSTALLIZATION EXPERIMENTS, INCLUDING CRYSTALLIZATION TRIALS, OPTIMIZATION, DATA COLLECTION AND INTERPRETATION. WHEN NECESSARY, KU WILL CONDUCT CO-CRYSTALLIZATION SCREENS OF THE TARGET IN COMPLEX WITH SMALL MOLECULES AND LIGANDS. KU WILL IDENTIFY AND HARVEST CRYSTALS THAT ARE SUITABLE FOR DIFFRACTION SCREENING AND CONDUCT LARGE SCALE CRYSTAL DIFFRACTION SCREENS, COLLECT DIFFRACTION DATA AND MONITOR QUALITY METRICS OF THE SUITABLE CRYSTALS. WHERE APPROPRIATE, KU WILL ALSO LIAISE WITH KUMC’S CRYOEM CENTER TO HELP SOLVE STRUCTURES BY CRYOEM.
KU WILL PERFORM STRUCTURE SOLUTION, MODEL REFINEMENT AND VALIDATION FOR X-RAY CRYSTALLOGRAPHY. A STRUCTURE DETERMINATION PROJECT WILL BE CONSIDERED COMPLETE WHEN THE REFINEMENT AND VALIDATION OF THE FINAL STRUCTURE MODELS DO NOT PROVIDE ANY CLEAR SIGNAL OF WHERE THE MODEL CAN BE IMPROVED OR WHEN 3D STRUCTURE QUALITY PARAMETERS SATISFY THE MINIMUM QUALITY REQUIREMENTS ESTABLISHED AND AGREED UPON IN COORDINATION WITH THE CENTER FOR STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.
KU WILL SUPPORT HIGH VALUE TARGETS (HVTS), COMMUNITY REQUEST PROJECTS (CRP), HIGHEST IMPACT PROJECTS (HIP) AND OTHER SPECIAL STUDIES WITHIN THE SSGCID PIPELINE, AS DECIDED BY THE SSGCID SCIENTIFIC LEADERSHIP TEAM (SLT).
B. FUNCTIONAL STUDIES
KU WILL LEAD ONE FUNCTION STUDY, ENTITLED “STRUCTURE AND FUNCTIONAL STUDIES OF THE TRANSCRIPTIONAL REGULATOR, GNTR FROM ENTEROCOCCUS FAECALIS.”
C. QUALITY CONTROL, DATA COLLECTION AND REPORTING:
KU WILL ESTABLISH AND CONDUCT QUALITY CONTROL PROCEDURES AS NECESSARY TO ENSURE THE PRODUCTION OF HIGH-QUALITY DATA. KU WILL ENSURE THAT THE STATUS OF ALL WORK PERFORMED FOR SSGCID IS UPDATED IN A TIMELY FASHION, THROUGH THE CENTRAL TARGET TRACKING DATABASE (CTTDB), TRACKING SPREADSHEETS AND/OR ANY OTHER TRACKING SYSTEM REQUIRED BY THE PROJECT. KEY STAFF MEMBERS FROM KU WILL PARTICIPATE IN SSGCID PROJECT MEETINGS AND NIAID-REQUIRED MEETINGS TO ENSURE THE SUCCESS OF THE PROJECT. KU STAFF WILL CONTRIBUTE TO QUARTERLY AND SEMI-ANNUAL PROGRESS REPORTS AND ANY OTHER NIAID REQUIRED REPORTS AS NEEDED AND IN A TIMELY FASHION AND WILL CONDUCT THE PROJECT WORK WITH THE AIM OF PRODUCING IMPACTFUL PUBLICATIONS.
IT IS EXPECTED THAT SEVENTY-FIVE STRUCTURES WILL BE SOLVED THROUGH THIS WORK. SUB00002669 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $669,207 | Sep 15, 2026 | — – — |
| Subcontractor | Department of Transportation | PHASE I STATE OF PRACTICE AND DRAFT FRAMEWORK
TASK 1. CONDUCT LITERATURE REVIEW
• DR. TRAN WILL ASSIST THE TEAM WITH REVIEWING THE INFORMATION GLEANED FROM THE LITERATURE REVIEW, INCLUDING IDENTIFYING GAPS IN EXISTING RESEARCH.
TASK 2. CONDUCT DESK SCAN AND DATA SYNTHESIS
• DR. TRAN WILL ASSIST THE TEAM IN RESEARCHING THE CURRENT STATE OF PRACTICE IN CONSTRUCTION INSPECTOR TRAINING AND CERTIFICATION FOR BRIDGE CONSTRUCTION AT AGENCIES AND REVIEW THE ANALYSIS OF THE DATA AND ANY FINDINGS.
TASK 3. IDENTIFY GAPS IN BRIDGE CONSTRUCTION INSPECTION CERTIFICATION
• DR. TRAN WILL ASSIST WITH DETERMINING GAPS IN EXISTING TRAINING AND CERTIFICATION PROGRAMS BASED ON INFORMATION COLLECTED IN TASK 2.
TASK 4. CONDUCT WEBINARS WITH AASHTO REGIONS
• DR. TRAN WILL ASSIST WITH THE PREPARATION AND EXECUTION OF THE WEBINARS.
TASK 5. DEVELOP DRAFT BRIDGE CONSTRUCTION INSPECTION CERTIFICATION FRAMEWORK
• DR. TRAN WILL HELP DEVELOP AND REVIEW THE DRAFT BRIDGE CONSTRUCTION INSPECTION CERTIFICATION FRAMEWORK.
PHASE II
TASK 6. REVIEW FRAMEWORK WITH SUBJECT MATTER EXPERTS
• DR. TRAN WILL PREPARE FOR AND CONDUCT MEETINGS WITH BRIDGE CONSTRUCTION INSPECTION EXPERTS TO TEST THE COMPLETENESS AND APPROPRIATENESS OF THE DRAFT FRAMEWORK.
TASK 7. DEVELOP FINAL DRAFT BRIDGE CONSTRUCTION INSPECTION CERTIFICATION FRAMEWORK
• DR. TRAN WILL ASSIST WITH DEVELOPING, REVIEWING AND EDITING OF THE FINAL FRAMEWORK.
TASK 8. DEVELOP FINAL DELIVERABLES AND DISSEMINATE THE RESULTS
• DR. TRAN WILL PROVIDE INPUT AND REVIEW OF ALL FINAL DELIVERABLES AND PARTICIPATE IN MEETINGS, WEBINARS AND PRESENTATIONS TO DISSEMINATE THE RESULTS. 3200006873-25-246 Parent award context Parent award agency: Department of Transportation · Federal Highway Administration Parent award NAICS: 541330 Parent award performance state: KY Parent award description: PRACTICAL FRAMEWORK FOR A BRIDGE AND TUNNEL CONSTRUCTION INSPECTION CERTIFICATION PROGRAM View parent award on USAspending | — | $45,000 | Aug 12, 2026 | — – — |
| Subcontractor | Department of Energy | R&D N000595782 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $35,000 | Mar 31, 2026 | — – — |
| Subcontractor | Department of Transportation | TASK 1. CONDUCT LITERATURE REVIEW
UKMC PI WILL ASSIST THE TEAM WITH REVIEWING THE INFORMATION GLEANED FROM THE LITERATURE REVIEW, INCLUDING IDENTIFYING GAPS IN EXISTING RESEARCH.
TASK 2. CONDUCT DESK SCAN AND DATA SYNTHESIS
UKMC PI WILL ASSIST THE TEAM IN RESEARCHING THE CURRENT STATE OF PRACTICE IN CONSTRUCTION INSPECTOR TRAINING AND CERTIFICATION FOR BRIDGE CONSTRUCTION AT AGENCIES AND REVIEW THE ANALYSIS OF THE DATA AND ANY FINDINGS.
TASK 3. IDENTIFY GAPS IN BRIDGE CONSTRUCTION INSPECTION CERTIFICATION
UKMC PI WILL ASSIST WITH DETERMINING GAPS IN EXISTING TRAINING AND CERTIFICATION PROGRAMS BASED ON INFORMATION COLLECTED IN TASK 2.
TASK 4. CONDUCT WEBINARS WITH AASHTO REGIONS
UKMC PI WILL ASSIST WITH THE PREPARATION AND EXECUTION OF THE WEBINARS.
TASK 5. DEVELOP DRAFT BRIDGE CONSTRUCTION INSPECTION CERTIFICATION FRAMEWORK
UKMC PI WILL HELP DEVELOP AND REVIEW THE DRAFT BRIDGE CONSTRUCTION INSPECTION CERTIFICATION FRAMEWORK.
PHASE II
TASK 6. REVIEW FRAMEWORK WITH SUBJECT MATTER EXPERTS
UKMC PI WILL PREPARE FOR AND CONDUCT MEETINGS WITH BRIDGE CONSTRUCTION INSPECTION EXPERTS TO TEST THE COMPLETENESS AND APPROPRIATENESS OF THE DRAFT FRAMEWORK.
TASK 7. DEVELOP FINAL DRAFT BRIDGE CONSTRUCTION INSPECTION CERTIFICATION FRAMEWORK
UKMC PI WILL ASSIST WITH DEVELOPING, REVIEWING AND EDITING OF THE FINAL FRAMEWORK.
TASK 8. DEVELOP FINAL DELIVERABLES AND DISSEMINATE THE RESULTS
UKMC PI WILL PROVIDE INPUT AND REVIEW OF ALL FINAL DELIVERABLES AND PARTICIPATE IN MEETINGS, WEBINARS AND PRESENTATIONS TO DISSEMINATE THE RESULTS. 3200006873-25-246 Parent award context Parent award agency: Department of Transportation · Federal Highway Administration Parent award NAICS: 541330 Parent award performance state: KY Parent award description: PRACTICAL FRAMEWORK FOR A BRIDGE AND TUNNEL CONSTRUCTION INSPECTION CERTIFICATION PROGRAM View parent award on USAspending | — | -$12,643 | Feb 24, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK TO SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2025-8/31/2026). KU WILL ACCEPT PROTEIN AND OTHER SAMPLES PRIMARILY GENERATED BY OTHER SSGCID SITES AND PREPARE THEM FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES, CONDUCT CRYSTALLIZATION EXPERIMENTS, COLLECT DIFFRACTION DATA, AND PERFORM STRUCTURE SOLUTION. KU WILL ALSO SUPPORT VARIOUS SPECIAL PROJECT STUDIES AS NEEDED AND LEAD ONE FUNCTIONAL STUDY.
STRUCTURE DETERMINATION OF PROTEINS OR PROTEIN COMPLEXES BY X-RAY CRYSTALLOGRAPHY:
KU WILL ACCEPT PROTEIN SAMPLES PRIMARILY RECEIVED FROM THE OTHER TEAM SITES FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES AND CONDUCT HIGH THROUGHPUT CRYSTALLIZATION EXPERIMENTS, INCLUDING CRYSTALLIZATION TRIALS, OPTIMIZATION, DATA COLLECTION AND INTERPRETATION. WHEN NECESSARY, KU WILL CONDUCT CO-CRYSTALLIZATION SCREENS OF THE TARGET IN COMPLEX WITH SMALL MOLECULES AND LIGANDS. KU WILL IDENTIFY AND HARVEST CRYSTALS THAT ARE SUITABLE FOR DIFFRACTION SCREENING AND CONDUCT LARGE SCALE CRYSTAL DIFFRACTION SCREENS, COLLECT DIFFRACTION DATA AND MONITOR QUALITY METRICS OF THE SUITABLE CRYSTALS. WHERE APPROPRIATE, KU WILL ALSO LIAISE WITH KUMC’S CRYOEM CENTER TO HELP SOLVE STRUCTURES BY CRYOEM.
KU WILL PERFORM STRUCTURE SOLUTION, MODEL REFINEMENT AND VALIDATION FOR X-RAY CRYSTALLOGRAPHY. A STRUCTURE DETERMINATION PROJECT WILL BE CONSIDERED COMPLETE WHEN THE REFINEMENT AND VALIDATION OF THE FINAL STRUCTURE MODELS DO NOT PROVIDE ANY CLEAR SIGNAL OF WHERE THE MODEL CAN BE IMPROVED OR WHEN 3D STRUCTURE QUALITY PARAMETERS SATISFY THE MINIMUM QUALITY REQUIREMENTS ESTABLISHED AND AGREED UPON IN COORDINATION WITH THE CENTER FOR STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.
KU WILL SUPPORT HIGH VALUE TARGETS (HVTS), COMMUNITY REQUEST PROJECTS (CRP), HIGHEST IMPACT PROJECTS (HIP) AND OTHER SPECIAL STUDIES WITHIN THE SSGCID PIPELINE, AS DECIDED BY THE SSGCID SCIENTIFIC LEADERSHIP TEAM (SLT).
FUNCTIONAL STUDIES
KU WILL LEAD ONE FUNCTION STUDY, ENTITLED “STRUCTURE AND FUNCTIONAL STUDIES OF THE TRANSCRIPTIONAL REGULATOR, GNTR FROM ENTEROCOCCUS FAECALIS.”
QUALITY CONTROL, DATA COLLECTION AND REPORTING:
KU WILL ESTABLISH AND CONDUCT QUALITY CONTROL PROCEDURES AS NECESSARY TO ENSURE THE PRODUCTION OF HIGH-QUALITY DATA. KU WILL ENSURE THAT THE STATUS OF ALL WORK PERFORMED FOR SSGCID IS UPDATED IN A TIMELY FASHION, THROUGH THE CENTRAL TARGET TRACKING DATABASE (CTTDB), TRACKING SPREADSHEETS AND/OR ANY OTHER TRACKING SYSTEM REQUIRED BY THE PROJECT. KEY STAFF MEMBERS FROM KU WILL PARTICIPATE IN SSGCID PROJECT MEETINGS AND NIAID-REQUIRED
MEETINGS TO ENSURE THE SUCCESS OF THE PROJECT. KU STAFF WILL CONTRIBUTE TO QUARTERLY AND SEMI-ANNUAL PROGRESS REPORTS AND ANY OTHER NIAID REQUIRED REPORTS AS NEEDED AND IN A TIMELY FASHION AND WILL CONDUCT THE PROJECT WORK WITH THE AIM OF PRODUCING IMPACTFUL PUBLICATIONS.
IT IS EXPECTED THAT SEVENTY-FIVE STRUCTURES WILL BE SOLVED THROUGH THIS WORK SUB00002485 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $638,316 | Sep 16, 2025 | — – — |
| Subcontractor | Department of Defense | ENGINEERING SERVICES P000029662 RELEASE 4 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: MD Parent award description: EXPERIMENTATION, INTEGRATION, AND TRANSITION PROGRAM FOR ARMY RESEARCH LABORATORY (ARL) PHOTONICS, ELECTRONICS, AND QUANTUM SCIENCES DIVISION (PEQS) View parent award on USAspending | FA807518D0002USAspending | $3,856,752 | Mar 19, 2025 | — – — |
| Subcontractor | Department of Defense | STTR PHASE I - STTR OPTIMIZED OTHR WAVEFORM AND PROCESSING 2025-KU-001 · Prime awardUSAspending | — | $70,000 | Jan 30, 2025 | — – — |
| Subcontractor | Department of Energy | R&D N000544990 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $100,000 | Nov 20, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000544858 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $54,291 | Nov 18, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000544472 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $99,988 | Nov 14, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK (OPTION QUANTITY 6) TO ADDITIONALLY SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2024-8/31/2025) OF THE SSGCID CONTRACT (CONTRACT NR 75N93022C00036). KU WILL LEAD ONE OPTION QUANTITY EFFORT (OQ 6) TO CONDUCT STUDIES ON TICK BORNE DISEASES.
A. OPTION QUANTITY EFFORTS
KU WILL USE OPTION QUANTITY RESOURCES (OQ 6) TO WORK ON A PROJECT FOCUSED ON LOLA FROM ORGANISMS THAT CAUSE TICK-BORNE DISEASES SUCH AS F. TULARENSIS AND E. RUMINANTIUM. THE FOCUS OF THIS WORK IS TO ANALYZE COMPOUNDS TARGETING THE LOLA PROTEIN USING SURFACE PLASMON RESONANCE AND TO ULTIMATELY OBTAIN A STRUCTURE(S) WITH LIGAND(S) BOUND. 13465SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $89,878 | Oct 31, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK TO SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2024-8/31/2025). KU WILL ACCEPT PROTEIN AND OTHER SAMPLES PRIMARILY GENERATED BY OTHER SSGCID SITES AND PREPARE THEM FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES, CONDUCT CRYSTALLIZATION EXPERIMENTS, COLLECT DIFFRACTION DATA, AND PERFORM STRUCTURE SOLUTION. KU WILL ALSO SUPPORT VARIOUS SPECIAL PROJECT STUDIES AS NEEDED AND LEAD ONE FUNCTIONAL STUDY.
A. STRUCTURE DETERMINATION OF PROTEINS OR PROTEIN COMPLEXES BY X-RAY CRYSTALLOGRAPHY:
KU WILL ACCEPT PROTEIN SAMPLES PRIMARILY RECEIVED FROM THE OTHER TEAM SITES FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES AND CONDUCT HIGH THROUGHPUT CRYSTALLIZATION EXPERIMENTS, INCLUDING CRYSTALLIZATION TRIALS, OPTIMIZATION, DATA COLLECTION AND INTERPRETATION. WHEN NECESSARY, KU WILL CONDUCT CO-CRYSTALLIZATION SCREENS OF THE TARGET IN COMPLEX WITH SMALL MOLECULES AND LIGANDS. KU WILL IDENTIFY AND HARVEST CRYSTALS THAT ARE SUITABLE FOR DIFFRACTION SCREENING AND CONDUCT LARGE SCALE CRYSTAL DIFFRACTION SCREENS, COLLECT DIFFRACTION DATA AND MONITOR QUALITY METRICS OF THE SUITABLE CRYSTALS. WHERE APPROPRIATE, KU WILL ALSO LIAISE WITH KUMC€„¢S CRYOEM CENTER TO HELP SOLVE STRUCTURES BY CRYOEM.
KU WILL PERFORM STRUCTURE SOLUTION, MODEL REFINEMENT AND VALIDATION FOR X-RAY CRYSTALLOGRAPHY. A STRUCTURE DETERMINATION PROJECT WILL BE CONSIDERED COMPLETE WHEN THE REFINEMENT AND VALIDATION OF THE FINAL STRUCTURE MODELS DO NOT PROVIDE ANY CLEAR SIGNAL OF WHERE THE MODEL CAN BE IMPROVED OR WHEN 3D STRUCTURE QUALITY PARAMETERS SATISFY THE MINIMUM QUALITY REQUIREMENTS ESTABLISHED AND AGREED UPON IN COORDINATION WITH THE CENTER FOR STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.
KU WILL SUPPORT HIGH VALUE TARGETS (HVTS), COMMUNITY REQUEST PROJECTS (CRP), HIGHEST IMPACT PROJECTS (HIP) AND OTHER SPECIAL STUDIES WITHIN THE SSGCID PIPELINE, AS DECIDED BY THE SSGCID SCIENTIFIC LEADERSHIP TEAM (SLT).
B. FUNCTIONAL STUDIES
KU WILL LEAD ONE FUNCTION STUDY, ENTITLED €œSTRUCTURE AND FUNCTIONAL STUDIES OF RSBU FROM CHLAMYDIA,€Ͽ½ WITH THE GOAL TO PERFORM STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE RSBU PROTEIN FROM C. TRACHOMATIS.
C. QUALITY CONTROL, DATA COLLECTION AND REPORTING:
KU WILL ESTABLISH AND CONDUCT QUALITY CONTROL PROCEDURES AS NECESSARY TO ENSURE THE PRODUCTION OF HIGH-QUALITY DATA. KU WILL ENSURE THAT THE STATUS OF ALL WORK PERFORMED FOR SSGCID IS UPDATED IN A TIMELY FASHION, THROUGH THE CENTRAL TARGET TRACKING DATABASE (CTTDB), TRACKING SPREADSHEETS AND/OR ANY OTHER TRACKING SYSTEM REQUIRED BY THE PROJECT. KEY STAFF MEMBERS FROM KU WILL PARTICIPATE IN SSGCID PROJECT MEETINGS AND NIAID-REQUIRED MEETINGS TO ENSURE THE SUCCESS OF THE PROJECT. KU STAFF WILL CONTRIBUTE TO QUARTERLY AND SEMI-ANNUAL PROGRESS REPORTS AND ANY OTHER NIAID REQUIRED REPORTS AS NEEDED AND IN A TIMELY FASHION AND WILL CONDUCT THE PROJECT WORK WITH THE AIM OF PRODUCING IMPACTFUL PUBLICATIONS.
IT IS EXPECTED THAT SIXTY STRUCTURES WILL BE SOLVED THROUGH THIS WORK. 13447SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $623,836 | Oct 31, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK (OPTION QUANTITY 2) TO ADDITIONALLY SUPPORT THE BASIC PROJECT REQUIREMENT OF THE SSGCID CONTRACT (CONTRACT NR 75N93022C00036) FROM SEPT 1, 2024 THROUGH AUG 31, 2025. KU WILL PARTICIPATE IN ONE OPTION QUANTITY EFFORT (OQ 2) TO CONDUCT STUDIES FOCUSED ON SOLVING THE STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEINS IMPORTANT FOR DRUG DISCOVERY. SOME OF THIS WORK WILL BE PERFORMED IN COLLABORATION WITH THE STRUCTURE-GUIDED DRUG DISCOVERY COALITION.
A. OPTION QUANTITY EFFORTS
KU WILL USE OPTION QUANTITY RESOURCES (OQ 2) TO WORK ON A PROJECT FOCUSED ON SOLVING THE STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TARGETS. THE FOCUS OF THIS WORK IS TO PERFORM RESCUE EFFORTS ON TARGETS THAT ARE IMPORTANT THE DEVELOPMENT OF NEW DRUGS AGAINST M. TUBERCULOSIS. KU STAFF WILL SUGGEST TRUNCATIONS AND OTHER STRATEGIES FOR RESCUE EFFORTS, PERFORM CRYSTALLIZATION TRAILS, AND SOLVE STRUCTURES FOR THIS PROJECT. 13448SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $99,929 | Oct 31, 2024 | — – — |
| Subcontractor | Department of Labor | SUBCONTRACT 2-312-0219327 INITIAL AWARD 2-312-0219327 Parent award context Parent award agency: Department of Labor · Office of the Assistant Secretary for Administration and Management Parent award NAICS: 541219 Parent award performance state: NC Parent award description: RFQ FOR NLSY26 SCREENING, DESIGN, AND R1 COLLECTION & DATA PROCESSING View parent award on USAspending | GS00Q14OADU217USAspending | $90,257 | Oct 1, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000506642 MOD 2 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $5,730 | Aug 15, 2024 | — – — |
| Subcontractor | Department of Defense | UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC. GO2301-KU-10-LTC-PO3 Parent award context Parent award agency: Department of Defense · Defense Human Resources Activity Parent award NAICS: 611710 Parent award performance state: VA Parent award description: PROJECT LTC GRANT View parent award on USAspending | — | $450,000 | May 31, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000524379 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $74,999 | May 21, 2024 | — – — |
| Subcontractor | Department of Energy | RESEARCH AND DEVELOPMENT N000521938 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $66,387 | Apr 30, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000516760 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $105,000 | Apr 18, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000518357 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $200,000 | Apr 1, 2024 | — – — |
| Subcontractor | Department of Energy | RESEARCH & DEVELOPMENT N000516760 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $105,000 | Mar 18, 2024 | — – — |
| Subcontractor | Department of Defense | SBIR PHASE II OPTIMIZED WAVEFORM RESEARCH PARTNER 2024-KU-001 Parent award context Parent award agency: Department of Defense · Missile Defense Agency Parent award NAICS: 541715 Parent award performance state: AL Parent award description: SBIR/STTR PHASE II R&D DOPPLER TOLERANT RANDOM FREQUENCY MODULATED WAVEFORMS View parent award on USAspending | — | $450,000 | Mar 8, 2024 | — – — |
| Subcontractor | Department of Education | DR. VALERIE MAZZOTTI, CO-PI OF THE EVALUATION OF TRANSITION SUPPORTS FOR YOUTH WITH DISABILITIES PROJECT, AND OTHER KU STAFF SHALL PROVIDE SERVICES IN SUPPORT OF THE EVALUATION OF TRANSITION SUPPORTS FOR YOUTH WITH DISABILITIES PROJECT THAT THE AIR-LED TEAM IS CONDUCTING FOR THE U.S. DEPARTMENT OF EDUCATION AS EXPRESSLY SET FORTH BELOW: TASK 8.2: ONGOING COMMUNICATION, TASK 9 – PREPARE OMB FORMS CLEARANCE PACKAGES, DEVELOP DATA COLLECTION FORMS, AND DOCUMENT INSTITUTIONAL REVIEW BOARD (IRB) APPROVAL, TASK 36.1 – DEVELOP STUDENT SURVEY, TASK 10.3: CONSULT WITH TWG MEMBERS AS NEEDED, TASK 12.1: PLAN AND PREPARE FOR IMPLEMENTATION, TASK 12.2: PILOT IMPLEMENTATION, TASK 13: MONTHLY REPORTING, MONTHS 33—75, TASK 16.1: ONGOING COMMUNICATION, TASK 17: SUPPORT FOR YEAR 1 IMPLEMENTATION AND MONITORING OF ADDITIONAL TRAINING, TASK 18.2: COLLECT YEAR 1 IMPLEMENTATION DATA, TASK 20: SUPPORT FOR YEAR 1 IMPLEMENTATION AND MONITORING OF ADDITIONAL TRAINING FOR SECOND TRANSITION STRATEGY, TASK 21: DATA COLLECTION (FOR YEAR 1) ASSOCIATED WITH ADDITIONAL SITES, TASK 22.1: ONGOING COMMUNICATION, TASK 23: SUPPORT FOR YEAR 2 IMPLEMENTATION AND MONITORING OF ADDITIONAL TRAINING, TASK 24: COLLECT YEAR 2 IMPLEMENTATION DATA, TASK 25: MONTHLY REPORTING, MONTHS 76—120, TASK 26: SUPPORT FOR YEAR 2 IMPLEMENTATION AND MONITORING OF ADDITIONAL TRAINING FOR SECOND TRANSITION STRATEGY, TASK 27: DATA COLLECTION (FOR YEAR 2) ASSOCIATED WITH ADDITIONAL SITES, TASK 28.2: BRIEF IES, TASK 29.1: SUPPORT TWG MEETING, TASK 29.2: CONSULT WITH TWG MEMBERS AS NEEDED, TASK 29.3: CONVENE SECOND IMPACT STUDY TWG MEETING, TASK 30.1: ANALYSIS PLAN, TASK 30.2: INTERIM STUDY REPORT, TASK 33: ANALYSES AND REPORT PREPARATION ASSOCIATED WITH SECOND TRANSITION STRATEGY/PROGRAM, TASK 38.1: ONGOING COMMUNICATIONS, TASK 39.1: SUPPORT TWG MEETING, TASK 39.2: CONSULT WITH TWG MEMBERS AS NEEDED, TASK 39.3: CONVENE THIRD IMPACT TWG MEETING, TASK 40.1: ANALYSIS PLAN FOR POST HIGH SCHOOL OUTCOMES REPORT, TASK 40.2: POST HIGH SCHOOL OUTCOMES REPORT, TASK 42: MONTHLY REPORTING, MONTHS 121-136 0489800006 Parent award context Parent award agency: Department of Education · Department of Education Parent award NAICS: 541720 Parent award performance state: DC Parent award description: THIS CONTRACT IS TO CONDUCT AN IMPLEMENTATION AND IMPACT EVALUATION STUDY OF TRANSITION SERVICES FOR STUDENTS WITH DISABILITIES, SPECIFICALLY THEIR EFFECTS ON IMPROVING POST-HIGH SCHOOL OUTCOMES. View parent award on USAspending | — | $531,336 | Jan 9, 2024 | — – — |
| Subcontractor | Department of Defense | R&D-SCHOOLS, NON-MIT 7000602805 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541712 Parent award performance state: MA Parent award description: IGF::CT::IGF TASK ORDER 0001 FOR DOD LINE FUNDING View parent award on USAspending | FA870215D0001USAspending | $284,690 | Jan 5, 2024 | — – — |
| Subcontractor | Department of Energy | R&D N000506642 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $210,000 | Dec 5, 2023 | — – — |
| Subcontractor | Department of Energy | RESEARCH AND DEVELOPMENT N000506684 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $98,932 | Dec 5, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK (OPTION QUANTITY 7) TO ADDITIONALLY SUPPORT THE BASIC PROJECT REQUIREMENT (9/7/2023-8/31/2024) OF THE SSGCID CONTRACT (CONTRACT NR 75N93022C00036) FROM SEPT 7, 2023 THROUGH AUG 31, 2024. KU WILL PARTICIPATE IN ONE OPTION QUANTITY EFFORT (OQ 7) TO CONDUCT STUDIES IN SUPPORT OF APP.
A. OPTION QUANTITY EFFORTS
KU WILL USE OPTION QUANTITY RESOURCES (OQ 7) TO WORK ON A PROJECT FOCUSED ON BUNYAVIRUSES. THE FOCUS OF THIS WORK IS TO DETERMINE THE STRUCTURES OF BUNYAVIRUS TARGETS THAT COULD BE POTENTIAL DRUG TARGETS. THE KU STAFF WILL PERFORM CRYSTALLIZATION, STRUCTURE SOLUTION, LIGAND SOAKING, AND/OR FRAGMENT SCREENING STUDIES FOR THIS PROJECT. 13189SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $52,484 | Oct 31, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK (OPTION QUANTITY 4) TO ADDITIONALLY SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2023-8/31/2024) OF THE SSGCID CONTRACT (CONTRACT NR 75N93022C00036) FROM SEPT 1, 2023 THROUGH AUG 31, 2024. KU WILL PARTICIPATE IN ONE OPTION QUANTITY EFFORT (OQ 4) TO CONDUCT STUDIES FOCUSED ON SARS-COV-2.
A. OPTION QUANTITY EFFORTS
KU WILL USE OPTION QUANTITY RESOURCES (OQ 4) TO WORK ON A PROJECT FOCUSED ON COVID19. THE FOCUS OF THIS WORK IS TO STUDY HOW PH AFFECTS THE STRUCTURE AND FUNCTION OF NSP15, WHICH IS THE TARGET OF DRUG DISCOVERY EFFORTS FOR COVID19. THE KU STAFF WILL PERFORM CRYSTALLIZATION, LIGAND SOAKING, AND/OR FRAGMENT SCREENING STUDIES FOR THIS PROJECT. 13169SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $34,622 | Oct 31, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK TO SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2023-8/31/2024). KU WILL ACCEPT PROTEIN AND OTHER SAMPLES PRIMARILY GENERATED BY OTHER SSGCID SITES AND PREPARE THEM FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES, CONDUCT CRYSTALLIZATION EXPERIMENTS, COLLECT DIFFRACTION DATA, AND PERFORM STRUCTURE SOLUTION. KU WILL ALSO SUPPORT VARIOUS SPECIAL PROJECT STUDIES AS NEEDED AND LEAD ONE FUNCTIONAL STUDY.
A. STRUCTURE DETERMINATION OF PROTEINS OR PROTEIN COMPLEXES BY X-RAY CRYSTALLOGRAPHY:
KU WILL ACCEPT PROTEIN SAMPLES PRIMARILY RECEIVED FROM THE OTHER TEAM SITES FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES AND CONDUCT HIGH THROUGHPUT CRYSTALLIZATION EXPERIMENTS, INCLUDING CRYSTALLIZATION TRIALS, OPTIMIZATION, DATA COLLECTION AND INTERPRETATION. WHEN NECESSARY, KU WILL CONDUCT CO-CRYSTALLIZATION SCREENS OF THE TARGET IN COMPLEX WITH SMALL MOLECULES AND LIGANDS. KU WILL IDENTIFY AND HARVEST CRYSTALS THAT ARE SUITABLE FOR DIFFRACTION SCREENING AND CONDUCT LARGE SCALE CRYSTAL DIFFRACTION SCREENS, COLLECT DIFFRACTION DATA AND MONITOR QUALITY METRICS OF THE SUITABLE CRYSTALS.
KU WILL PERFORM STRUCTURE SOLUTION, MODEL REFINEMENT AND VALIDATION FOR X-RAY CRYSTALLOGRAPHY. A STRUCTURE DETERMINATION PROJECT WILL BE CONSIDERED COMPLETE WHEN THE REFINEMENT AND VALIDATION OF THE FINAL STRUCTURE MODELS DO NOT PROVIDE ANY CLEAR SIGNAL OF WHERE THE MODEL CAN BE IMPROVED OR WHEN 3D STRUCTURE QUALITY PARAMETERS SATISFY THE MINIMUM QUALITY REQUIREMENTS ESTABLISHED AND AGREED UPON IN COORDINATION WITH THE CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES.
KU WILL SUPPORT HIGH VALUE TARGETS (HVTS), COMMUNITY REQUEST PROJECTS (CRP), HIGHEST IMPACT PROJECTS (HIP) AND OTHER SPECIAL STUDIES WITHIN THE SSGCID PIPELINE, AS DECIDED BY THE SSGCID SCIENTIFIC LEADERSHIP TEAM (SLT).
B. FUNCTIONAL STUDIES
KU WILL LEAD ONE FUNCTION STUDY, ENTITLED €œSTRUCTURE AND FUNCTIONAL STUDIES OF RSBU FROM CHLAMYDIA,€Ͽ½ WITH THE GOAL TO PERFORM STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE RSBU PROTEIN FROM C. TRACHOMATIS.
C. QUALITY CONTROL, DATA COLLECTION AND REPORTING:
KU WILL ESTABLISH AND CONDUCT QUALITY CONTROL PROCEDURES AS NECESSARY TO ENSURE THE PRODUCTION OF HIGH-QUALITY DATA. KU WILL ENSURE THAT THE STATUS OF ALL WORK PERFORMED FOR SSGCID IS UPDATED IN A TIMELY FASHION, THROUGH THE CENTRAL TARGET TRACKING DATABASE (CTTDB), TRACKING SPREADSHEETS AND/OR ANY OTHER TRACKING SYSTEM REQUIRED BY THE PROJECT. KEY STAFF MEMBERS FROM KU WILL PARTICIPATE IN SSGCID PROJECT MEETINGS AND NIAID-REQUIRED MEETINGS TO ENSURE THE SUCCESS OF THE PROJECT. KU STAFF WILL CONTRIBUTE TO QUARTERLY AND SEMI-ANNUAL PROGRESS REPORTS AND ANY OTHER NIAID REQUIRED REPORTS AS NEEDED AND IN A TIMELY FASHION AND WILL CONDUCT THE PROJECT WORK WITH THE AIM OF PRODUCING IMPACTFUL PUBLICATIONS.
IT IS EXPECTED THAT SIXTY STRUCTURES WILL BE SOLVED THROUGH THIS WORK. 13165SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $619,592 | Oct 31, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK (OPTION QUANTITY 8) TO ADDITIONALLY SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2023-8/31/2024) OF THE SSGCID CONTRACT (CONTRACT NR 75N93022C00036) FROM SEPT 1, 2023 THROUGH AUG 31, 2024. KU WILL PARTICIPATE IN ONE OPTION QUANTITY EFFORT (OQ 8) TO CONDUCT STUDIES ON TICK BORNE DISEASES.
A. OPTION QUANTITY EFFORTS
KU WILL USE OPTION QUANTITY RESOURCES (OQ 8) TO WORK ON A PROJECT FOCUSED ON LOLA. THE FOCUS OF THIS WORK IS TO COMPLETE FRAGMENT SCREENING AND PERFORM FOLLOW UP STRUCTURAL BIOLOGY AND DRUG DEVELOPMENT STUDIES ON THE TARGET LOLA IN ORGANISMS THAT ARE TICK-BORNE. THE KU STAFF WILL PERFORM CRYSTALLIZATION, STRUCTURE SOLUTION, LIGAND SOAKING, AND/OR DRUG DISCOVERY AND FRAGMENT SCREENING STUDIES FOR THIS PROJECT. 13190SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $128,200 | Oct 31, 2023 | — – — |
| Subcontractor | Department of Defense | SUPPORT SERVICES TO CREATE END-TO-END RADAR WAVEFORM SELECTION, PROCESSING CHAIN, AND TRACKER CAPABILITY UTILIZING PARTIALLY ADAPTIVE AND ITERATIVE PROCESSING OF NON-REPETITIVE WAVEFORMS IN THE PRESENCE OF MAINBEAM INTERFERENCE OVER TWO PHASES. 2023-0054 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: MA Parent award description: SMALLER TARGETING RADARS WITH INTEGRATED PERFORMANCE EQUIVALENCY View parent award on USAspending | — | $358,831 | Oct 4, 2023 | — – — |
| Subcontractor | Department of Defense | UNIVERSITY OF KANSAS PGO2301-KU-10-PGO-PO2 Parent award context Parent award agency: Department of Defense · Defense Human Resources Activity Parent award NAICS: 611710 Parent award performance state: VA Parent award description: PROJECT LTC GRANT View parent award on USAspending | — | $606,882 | Sep 15, 2023 | — – — |
| Subcontractor | National Aeronautics and Space Administration | IN PHASE I, KU WILL FOCUS
ON THE IDENTIFICATION OF CANDIDATE ILS AS A SOLVENT FOR THE SOLUBILIZATION OF WATER AND VOLATILE GASES
FROM THE ICY LUNAR REGOLITH SIMULANT. SC4027087-440001-46 · Prime awardUSAspending | — | $35,000 | Aug 3, 2023 | — – — |
| Subcontractor | Department of Education | THIS INITIAL STATEMENT OF WORK (SOW) DESCRIBES A GROUP OF TASKS FOR KU TO WORK WITH AIR AND UNCC AS PART OF A “PROVIDER TEAM” RESPONSIBLE FOR ENABLING STRONG IMPLEMENTATION OF TWO PROGRAMS TO PREPARE HIGH SCHOOL YOUTH WITH DISABILITIES (YWD) ACHIEVE SUCCESS AFTER HIGH SCHOOL. THESE PROGRAMS ARE TO BE IMPLEMENTED AS PART OF AN EVALUATION PROJECT THAT AN AIR-LED “STUDY TEAM” IS CONDUCTING FOR THE U.S. DEPARTMENT OF EDUCATION (ED) (“THE PROJECT”). ADDITIONAL GROUPS OF MAY BE INCORPORATED INTO THE SOW IN THE FUTURE FOR OTHER ACTIVITIES TO BE CONDUCTED BY KU IN COLLABORATION WITH AIR AS PART OF THE PROJECT. 0489800005 Parent award context Parent award agency: Department of Education · Department of Education Parent award NAICS: 541720 Parent award performance state: DC Parent award description: THIS CONTRACT IS TO CONDUCT AN IMPLEMENTATION AND IMPACT EVALUATION STUDY OF TRANSITION SERVICES FOR STUDENTS WITH DISABILITIES, SPECIFICALLY THEIR EFFECTS ON IMPROVING POST-HIGH SCHOOL OUTCOMES. View parent award on USAspending | — | $388,407 | Jun 26, 2023 | — – — |
| Subcontractor | Department of Defense | UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC. PGO2301-KU-10-LTC-PO1 Parent award context Parent award agency: Department of Defense · Defense Human Resources Activity Parent award NAICS: 611710 Parent award performance state: VA Parent award description: PROJECT LTC GRANT View parent award on USAspending | — | $596,960 | Jun 5, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK TO SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2022-8/31/2023). KU WILL ACCEPT PROTEIN AND OTHER SAMPLES PRIMARILY GENERATED BY OTHER SSGCID SITES AND PREPARE THEM FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES, CONDUCT CRYSTALLIZATION EXPERIMENTS, COLLECT DIFFRACTION DATA, AND PERFORM STRUCTURE SOLUTION. KU WILL ALSO SUPPORT VARIOUS SPECIAL PROJECT STUDIES AS NEEDED AND LEAD ONE FUNCTIONAL STUDY.
A. STRUCTURE DETERMINATION OF PROTEINS OR PROTEIN COMPLEXES BY X-RAY CRYSTALLOGRAPHY:
KU WILL ACCEPT PROTEIN SAMPLES PRIMARILY RECEIVED FROM THE OTHER TEAM SITES FOR X-RAY CRYSTALLOGRAPHY STRUCTURE DETERMINATION STUDIES AND CONDUCT HIGH THROUGHPUT CRYSTALLIZATION EXPERIMENTS, INCLUDING CRYSTALLIZATION TRIALS, OPTIMIZATION, DATA COLLECTION AND INTERPRETATION. WHEN NECESSARY, KU WILL CONDUCT CO-CRYSTALLIZATION SCREENS OF THE TARGET IN COMPLEX WITH SMALL MOLECULES AND LIGANDS. KU WILL IDENTIFY AND HARVEST CRYSTALS THAT ARE SUITABLE FOR DIFFRACTION SCREENING AND CONDUCT LARGE SCALE CRYSTAL DIFFRACTION SCREENS, COLLECT DIFFRACTION DATA AND MONITOR QUALITY METRICS OF THE SUITABLE CRYSTALS.
KU WILL PERFORM STRUCTURE SOLUTION, MODEL REFINEMENT AND VALIDATION FOR X-RAY CRYSTALLOGRAPHY. A STRUCTURE DETERMINATION PROJECT WILL BE CONSIDERED COMPLETE WHEN THE REFINEMENT AND VALIDATION OF THE FINAL STRUCTURE MODELS DO NOT PROVIDE ANY CLEAR SIGNAL OF WHERE THE MODEL CAN BE IMPROVED OR WHEN 3D STRUCTURE QUALITY PARAMETERS SATISFY THE MINIMUM QUALITY REQUIREMENTS ESTABLISHED AND AGREED UPON IN COORDINATION WITH THE CENTER FOR STRUCTURAL GENOMICS OF INFECTIOUS DISEASES.
KU WILL SUPPORT HIGH VALUE TARGETS (HVTS), COMMUNITY REQUEST PROJECTS (CRP), HIGHEST IMPACT PROJECTS (HIP) AND OTHER SPECIAL STUDIES WITHIN THE SSGCID PIPELINE, AS DECIDED BY THE SSGCID SCIENTIFIC LEADERSHIP TEAM (SLT).
B. FUNCTIONAL STUDIES
KU WILL LEAD ONE FUNCTION STUDY, ENTITLED €œIRON AND SMALL MOLECULE BINDING STUDIES OF BRUCELLA ABORTUS BACTERIOFERRITIN,€Ͽ½ WITH THE GOAL TO UTILIZE CRYSTAOLLGORY TO IDENTIFY IRON-BINDING SITES AND SMALL MOLECULE INHIBITOR BINDING SITE OF B. ABORTUS BACTERIOFERRITIN.
C. QUALITY CONTROL, DATA COLLECTION AND REPORTING:
KU WILL ESTABLISH AND CONDUCT QUALITY CONTROL PROCEDURES AS NECESSARY TO ENSURE THE PRODUCTION OF HIGH-QUALITY DATA. KU WILL ENSURE THAT THE STATUS OF ALL WORK PERFORMED FOR SSGCID IS UPDATED IN A TIMELY FASHION, THROUGH THE CENTRAL TARGET TRACKING DATABASE (CTTDB), TRACKING SPREADSHEETS AND/OR ANY OTHER TRACKING SYSTEM REQUIRED BY THE PROJECT. KEY STAFF MEMBERS FROM KU WILL PARTICIPATE IN SSGCID PROJECT MEETINGS AND NIAID-REQUIRED MEETINGS TO ENSURE THE SUCCESS OF THE PROJECT. KU STAFF WILL CONTRIBUTE TO QUARTERLY AND SEMI-ANNUAL PROGRESS REPORTS AND ANY OTHER NIAID REQUIRED REPORTS AS NEEDED AND IN A TIMELY FASHION AND WILL CONDUCT THE PROJECT WORK WITH THE AIM OF PRODUCING IMPACTFUL PUBLICATIONS.
IT IS EXPECTED THAT SIXTY STRUCTURES WILL BE SOLVED THROUGH THIS WORK. 12908SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $590,225 | Dec 31, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | THE UNIVERSITY OF KANSAS (KU), UNDER THE DIRECTION OF SCOTT LOVELL, PH.D., WILL PERFORM THE FOLLOWING WORK (OPTION QUANTITY 4) TO ADDITIONALLY SUPPORT THE BASIC PROJECT REQUIREMENT (9/1/2022-8/31/2023) OF THE SSGCID CONTRACT (CONTRACT NR 75N93022C00036) FROM SEPT 1, 2022 THROUGH AUG 31, 2023. KU WILL LEAD ONE OPTION QUANTITY EFFORT (OQ 4) TO CONDUCT STUDIES FOCUSED ON TICK BORNE DISEASES.
A. OPTION QUANTITY EFFORTS
KU WILL USE OPTION QUANTITY RESOURCES (OQ 4) TO WORK ON A PROJECT FOCUSED ON TICK BORNE DISEASES. THE STUDY OF THIS WORK IS TITLED INHIBITOR DEVELOPMENT FOR THE LOIA OUTER MEMBRANE LIPOPROTEIN CARRIER PROTEIN FROM BORRELIA BURGDORFERI. THE KU STAFF WILL PERFORM CRYSTALLIZATION, LIGAND SOAKING, FRAGMENT SCREENING, AND COMPUTATIONAL STUDIES FOR THIS PROJECT.
KU WILL ALSO SUPPORT THE OTHER FOUR OPTION QUANTITIES BY PERFORMING X-RAY CRYSTALLOGRAPHY WORK AND STRUCTURE SOLUTION AS DESCRIBED IN THE SOW FOR THE BASIC PROJECT REQUIREMENT.
IT IS EXPECTED THAT 10 STRUCTURES WILL BE SOLVED BY THE OPTION QUANTITY WORK BY X-RAY CRYSTALLOGRAPHY. 12917SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES. View parent award on USAspending | — | $81,652 | Dec 31, 2022 | — – — |
| Subcontractor | Department of Energy | PDRD N000459504 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $176,000 | Oct 28, 2022 | — – — |
| Subcontractor | Department of Defense | SUPPORT BLACK RIVER SYSTEMS UNDER THE ADAPS CONTRACT. 1515-S06 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541712 Parent award performance state: NY Parent award description: IGF::OT::IGF - SBIR PHASE III - ADAPTIVE DECISIONS FOR ACTIVE AND PASSIVE SYSTEMS (ADAPS) View parent award on USAspending | — | $180,000 | Jun 16, 2022 | — – — |
| Subcontractor | Department of Defense | SBIR PHASE I - OPTIMIZED WAVEFORMS FOR X BAND MISSILE DEFENSE RADARS 2022-KU-001 · Prime awardUSAspending | — | $40,000 | Jan 28, 2022 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of TransportationGov-sourced
- Department of DefenseGov-sourced
- National Science FoundationGov-sourced
- Department of Health and Human ServicesGov-sourced