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ST JUDE CHILDREN'S RESEARCH HOSPITAL INC
MEMPHIS, TN, 38105
Unclaimed
Other Than Small Business
Prime contracting experience
4 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services National Institutes of Health | AWARD OF THE BASE TO ST. JUDE FOR CEIRR CONTRACT 75N93021C00016. THIS CONTRACT WILL SUPPORT NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR). | — | $105,666,007 | Jul 27, 2026 | Apr 1, 2021 – Feb 28, 2029 |
| Prime | Department of Health and Human Services Food and Drug Administration | MODELING PEDIATRIC SOLID TUMORS AND THE TUMOR MICROENVIRONMENT - BAA PMWP 160 | — | $3,095,955 | Jul 7, 2025 | Aug 16, 2021 – Aug 31, 2026 |
| Prime | Department of Health and Human Services National Institutes of Health | BABY HUG FOLLOW-UP STUDY II | — | $485,339 | Aug 29, 2024 | Jan 6, 2012 – Jul 31, 2017 |
| Prime | Department of Health and Human Services National Institutes of Health | IGF::OT::IGF NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND SURVEILLANCE (CEIRS) | — | $132,603,698 | Dec 13, 2022 | Jan 9, 2014 – Oct 31, 2023 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
25 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $90,206 | Apr 16, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | SUBCONTRACTOR WILL BE RESPONSIBLE FOR OPERATIONS AND MAINTENANCE OF SCIENTIFIC ANALYSIS TOOLS WHICH INCLUDES IMPLEMENTING PRIORITIZED ENHANCEMENTS AND DEFECT FIXES OF EXISTING SCIENTIFIC ANALYSIS TOOLS. THE SCOPE ALSO INCLUDES INTEGRATING THE NCI IMAGING DATA COMMONS (IDC) PATHOLOGY VIEWER WITH THE GDC DATA PORTAL 2.0. 20X068F9 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: MD Parent award description: COMPARATIVE ONCOLOGY CLINICAL TRIALS View parent award on USAspending | 75N91019D00024USAspending | $223,833 | Oct 28, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA VACCINE RESEARCH FOR HIGH RISK POPULATIONS SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $1,100,000 | Aug 29, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $584,897 | May 29, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | THE SUBCONTRACTOR WILL PERFORM LABORATORY TESTING OF PROTOCOL SPECIMENS TO OBTAIN AND ANALYZE TRANSCRIPTOMIC DATA AS IT RELATES TO CMV INFECTION. THE SUBCONTRACTOR WILL PURCHASE AND PREPARE NECESSARY SUPPLIES FOR PROTOCOL PARTICIPANT RECRUITING SITES TO COLLECT PROTOCOL SPECIMENS AND ASSIST IN THE DEVELOPMENT OF REQUIRED LABORATORY PROCEDURES AND DOCUMENTATION FOR RECRUITING SITES TO ENSURE SPECIMENS ARE APPROPRIATELY COLLECTED, STORED, AND SHIPPED TO THE PROCESSING LAB. THE SUBCONTRACTOR WILL PARTICIPATE IN REGULAR AND AD HOC MEETINGS/TELECONFERENCES WITH LEAD UAB PI TO DISCUSS PROJECT STATUS AND PROVIDE UPDATES AND INFORMATION. THE SUBCONTRACT WILL SUBMIT ALL DATA TO LEAD SITE IN SUPPORT OF STUDY CLOSE-OUT, AS WELL AS ASSIST IN THE FINAL DATA ANALYSIS AS IT RELATES TO LAB RESULTS. 000509729-SC015-MEJ-A01 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541712 Parent award performance state: AL Parent award description: IGF::OT::IGF - TARGETED CLINICAL RESEARCH TO ADDRESS SELECT VIRAL INFECTIONS View parent award on USAspending | — | $11,550 | May 12, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $90,296 | Apr 17, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $802,317 | Jan 10, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | DEVELOPMENT OF SCIENTIFIC ANALYSIS TOOLS FOR THE GENOMIC DATA COMMONS PROJECT. 20X068F7 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: MD Parent award description: NCI FY25 OPERATIONAL TASK ORDER View parent award on USAspending | 75N91019D00024USAspending | $718,816 | Dec 9, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | THE SUBCONTRACTOR WILL PERFORM LABORATORY TESTING OF PROTOCOL SPECIMENS TO OBTAIN AND ANALYZE TRANSCRIPTOMIC DATA AS IT RELATES TO CMV INFECTION. THE SUBCONTRACTOR WILL PURCHASE AND PREPARE NECESSARY SUPPLIES FOR PROTOCOL PARTICIPANT RECRUITING SITES TO COLLECT PROTOCOL SPECIMENS AND ASSIST IN THE DEVELOPMENT OF REQUIRED LABORATORY PROCEDURES AND DOCUMENTATION FOR RECRUITING SITES TO ENSURE SPECIMENS ARE APPROPRIATELY COLLECTED, STORED, AND SHIPPED TO THE PROCESSING LAB. THE SUBCONTRACTOR WILL PARTICIPATE IN REGULAR AND AD HOC MEETINGS/TELECONFERENCES WITH LEAD UAB PI TO DISCUSS PROJECT STATUS AND PROVIDE UPDATES AND INFORMATION. THE SUBCONTRACT WILL SUBMIT ALL DATA TO LEAD SITE IN SUPPORT OF STUDY CLOSE-OUT, AS WELL AS ASSIST IN THE FINAL DATA ANALYSIS AS IT RELATES TO LAB RESULTS. 000509729-SC015-MEJ Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541712 Parent award performance state: AL Parent award description: IGF::OT::IGF - TARGETED CLINICAL RESEARCH TO ADDRESS SELECT VIRAL INFECTIONS View parent award on USAspending | — | $158,811 | Mar 2, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $360,000 | Dec 18, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA VACCINE RESEARCH FOR HIGH RISK POPULATIONS SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $1,131,479 | Dec 14, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | THE SCOPE OF WORK IS FOR THE DEVELOPMENT OF SCIENTIFIC ANALYSIS TOOLS IN SUPPORT OF THE GDC. 20X068F6 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: MD Parent award description: NCI OPERATIONAL TASK ORDER View parent award on USAspending | 75N91019D00024USAspending | $487,793 | Nov 29, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | OPTION 1: 0258-B504-4609
OPTION 2: 0258-C504-4609
OPTION 3: 0258-D504-4609
OPTION 4: IF300302118-940002
OPTION 5: IF300302188-940002
CRIPT MEMPHIS INFLUENZA COHORT AT ST JUDE CHILDREN€„¢S RESEARCH HOSPITAL
WE PROPOSE THREE SPECIFIC AIMS:
AIM 1 TO DEFINE THE CLINICAL AND DEMOGRAPHIC VARIABLES ASSOCIATED WITH SEVERE INFLUENZA INFECTION IN CHILDREN.
AIM 2 TO IDENTIFY THE VIROLOGIC AND IMMUNOLOGIC FACTORS ASSOCIATED WITH SEVERE INFLUENZA INFECTION IN CHILDREN.
AIM 3 ASSESS THE IMPACT OF SEVERE VS MILD INFLUENZA INFECTION IN THE LONG-TERM EVOLUTION AND ANTIBODY PROFILES AFTER REPEATED EXPOSURE THROUGH INFECTION AND VACCINATION.
TO ACCOMPLISH THESE AIMS
1. WILL ENROLL 60 PEDIATRIC PATIENTS WITH ACUTE INFLUENZA INFECTIONS PER YEAR AND COLLECT NASOPHARYNGEAL, BLOOD AND SALIVA SAMPLES FOR IMMUNOLOGIC AND VIROLOGIC ANALYSIS.
2. WITH A SELECTED GROUP OF PATIENTS, WE WILL ESTABLISH LONGITUDINAL COHORTS TO FOLLOW THEM FOR 3 YEARS (AND LONGER WHEN FEASIBLE) TO ASSESS IF AND HOW THE CHARACTERISTICS OF THEIR INFLUENZA INFECTION AFFECT THEIR IMMUNE RESPONSES TO SUBSEQUENT INFLUENZA VACCINATIONS. 0258-C504-4609 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: NY Parent award description: MSSM CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE. View parent award on USAspending | — | $1,574,868 | May 22, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $90,367 | May 11, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | IN SUPPORT OF THE CHILDHOOD CANCER DATA INITIATIVE (CCDI), LEIDOS BIOMEDICAL RESEARCH, INC. (LBR), WILL DEVELOP A CHILDHOOD CANCER DATA FEDERATION PLATFORM TO AGGREGATE AND INTEGRATE (AS APPROPRIATE) CLINICAL AND RESEARCH DATA OF PEDIATRIC CANCERS IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS. IN SUPPORT OF CBITT, THIS TASK ORDER SCOPE OF WORK SHALL INCLUDE DEFINING API REQUIREMENTS FOR THE CCDI FEDERATION AND IMPLEMENT REQUIREMENTS. 20X068F4 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: MD Parent award description: ENABLING NCI CLINICAL & RESEARCH DATA SHARING View parent award on USAspending | 75N91019D00024USAspending | $495,341 | Feb 2, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $601,617 | Jan 18, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) COMPONENT A: VACCINE CENTER SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $1,200,614 | Jan 3, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) COMPONENT A: VACCINE CENTER SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $118,475 | Dec 16, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA VACCINE RESEARCH FOR HIGH RISK POPULATIONS SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $450,000 | Nov 1, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) COMPONENT A: VACCINE CENTER SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $215,000 | Oct 20, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE€Ͽ½ (CEIRR) SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $90,325 | May 20, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | C. EFFICACY AND IMMUNOGENICITY OF GMP MANUFACTURED COBRA PRODUCTS
I. LEADERSHIP AND PROJECT MANAGEMENT: THIS CIVR-HRP OPTION PROGRAM IS UNDER THE DIRECTION OF DRS. STACEY SCHULTZ-CHERRY PH.D. FROM ST. JUDE CHILDREN€„¢S RESEARCH HOSPITAL AND TED M. ROSS, PH.D. FROM THE UNIVERSITY OF GEORGIA (UGA). BOTH INVESTIGATORS WILL SHARE RESPONSIBILITY FOR THE MANAGEMENT AND OVERSIGHT OF THE SCIENTIFIC ASPECTS OF THIS OPTION PROJECT. THEY WILL BE RESPONSIBLE FOR DEFINING THE RESEARCH OBJECTIVES, APPROACHES, AND EXECUTION OF THE PROGRAM, AND TO COMMUNICATE AND DIRECT THESE GOALS (AND MILESTONES). THE TEAM WILL WORK COLLABORATIVELY TO SUPPORT THE RESEARCH OBJECTIVES OF THE OPTION PROJECT.
II. OBJECTIVES: A CRITICAL COMPONENT OF OUR DATA PACKAGE AND MOVING OUR PRODUCTS INTO THE CLINICAL IS ENSURING THAT THE CIVR-HRP VACCINE PLATFORMS AND ANTIGENS ARE €œGMP-READY.€Ͽ½ THUS, THE OVERALL GOALS OF THIS CONCEPT ARE TO 1) PRODUCE GMP MASTER CELL BANKS STABLY EXPRESSING COBRA ANTIGENS, 2) DEVELOP PURIFICATION STRATEGIES FOR HA AND NA, 3) CHARACTERIZE PURIFIED ANTIGEN, AND 4) ASSESS IMMUNOGENICITY AND EFFICACY OF PRODUCTS COMPARED TO UGA PRODUCED PROTEINS. THESE STUDIES WILL BE PERFORMED IN COLLABORATION WITH THE ST JUDE CHILDREN€„¢S RESEARCH HOSPITAL (SJCRH) GMP FACILITY. THE END OUTCOME WILL BE PRODUCTS, PROTOCOLS AND RELEASE ASSAYS THAT CAN BE TRANSFERRED TO THE DUKE GMP FOR MANUFACTURING.
III. DELIVERABLES
€¢ AMPLIFICATION OF CHO MASTER CELL BANK
€¢ EXPRESSION AND SELECTION OF STABLY TRANSFECTED CELL LINES
€¢ PURIFICATION OF RECOMBINANT PROTEINS (HAS AND NAS)
€¢ CHARACTERIZATION OF PROTEINS AND COMPARISON TO UGA PROTEINS
€¢ TESTING IN PRECLINICAL ANIMALS
€¢ BIMONTHLY REPORTS.
€¢ PRESENTATIONS UPON REQUEST AT THE ANNUAL MEETING.
€¢ ALL REQUIRED INFORMATION PROVIDED TO SDMCC.
D. ADJUVANT ASSESSMENT WITH STANDARD OF CARE SPLIT-INACTIVATED INFLUENZA VACCINE.
I. LEADERSHIP AND PROJECT MANAGEMENT: THIS CIVR-HRP OPTION PROGRAM IS UNDER THE DIRECTION OF DRS. TED M. ROSS, PH.D. FROM THE UNIVERSITY OF GEORGIA (UGA) AND STACEY SCHULTZ-CHERRY PH.D. FROM ST. JUDE CHILDREN€„¢S RESEARCH HOSPITAL. BOTH INVESTIGATORS WILL SHARE RESPONSIBILITY FOR THE MANAGEMENT AND OVERSIGHT OF THE SCIENTIFIC ASPECTS OF THIS OPTION PROJECT. THEY WILL BE RESPONSIBLE FOR DEFINING THE RESEARCH OBJECTIVES, APPROACHES, AND EXECUTION OF THE PROGRAM, AND TO COMMUNICATE AND DIRECT THESE GOALS (AND MILESTONES). THE TEAM WILL WORK COLLABORATIVELY TO SUPPORT THE RESEARCH OBJECTIVES OF THE OPTION PROJECT.
II. OBJECTIVES: THE PRIMARY GOAL OF THIS PROJECT IS TO DETERMINE WHICH OF A SET OF NOVEL ADJUVANTS WILL ELICIT BROADLY PROTECTIVE IMMUNE RESPONSES IN MICE AND FERRETS USING COMMERCIAL SPLIT-INACTIVATED QUADRAVLENT INFLUENZA VACCINE AGAINST SEASONAL INFLUENZA VIRUSES. ADULT MICE AND FERRETS WILL BE USED TO TEST EACH OF THE SELECTED ADJUVANTS IN A DOSE-DEPENDENT MANNER TO ASSESS THE BREADTH OF PROTECTIVE ANTIBODY AND T CELL RESPONSES AGAINST GROUP 1 AND GROUP 2 INFLUENZA VIRUSES. UP TO 10 ADJUVANTS WILL BE TESTED IN THIS PROTOCOL AND BASED UPON EMPIRICAL AND STATISTICALLY SIGNIFICANT RESULTS, A SUBSET OF ADJUVANTS WILL BE TESTED IN AGED AND OBESE ANIMAL MODELS FOR EFFICACY.
III. DELIVERABLES
€¢ DATA ON IMMUNOLOGICAL ASSESSMENT OF NOVEL ADJUVANTS TO ENHANCE THE IMMUNOGENICITY OF SPLIT-INACTIVATED VACCINE IN HEALTHY ANIMALS.
€¢ DATA ON ASSESSMENT OF NOVEL ADJUVANTS TO ENHANCE THE PROTECTION AGAINST INFLUENZA INFECTION.
€¢ EXAMINATION OF NOVEL ADJUVANTS FOR SPLIT-INACTIVATED VACCINE IN AGED AND OBESE ANIMALS.
€¢ PUBLICATIONS AND REPORTS OF DATA FOR FUTURE USE IN CLINICAL TRIALS.
€¢ BIMONTHLY REPORTS.
€¢ PRESENTATIONS UPON REQUEST AT THE ANNUAL MEETING. SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $905,860 | Jan 13, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | TO PROVIDE THE CANCER RESEARCH COMMUNITY WITH A UNIFIED DATA REPOSITORY THAT ENABLES DATA SHARING ACROSS CANCER GENOMIC STUDIES IN SUPPORT OF PRECISION
MEDICINE. WORKING TOWARDS THIS MISSION, GENOMIC DATA COMMONS AIMS TO PROVIDE A CANCER KNOWLEDGE NETWORK THAT ENABLES THE IDENTIFICATION OF BOTH HIGH€Ͽ½ AND LOW€Ͽ½FREQUENCY CANCER DRIVERS, ASSISTS IN DEFINING GENOMIC DETERMINANTS OF RESPONSE TO THERAPY, AND INFORMS THE COMPOSITION OF CLINICAL TRIAL COHORTS SHARING TARGETED GENETIC LESIONS 20X068F3 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: MD Parent award description: NCI OPERATIONAL TASK ORDER View parent award on USAspending | 75N91019D00024USAspending | $350,739 | Dec 20, 2021 | — – — |
| Subcontractor | Department of Health and Human Services | SPRTA TO EXPANDE A LARGER STUDY OF COHORTS OF VACCINATED INDIVIDUALS AND TO EXPAND THE ANALYSES OF RESPONSES IN MINORITY POPULATIONS SHOULDERING A DISPROPORTIONALITY LARGE BURDEN OF COVID-19 DISEASE. THIS WORK IS PART OF THE LARGER NIAID EFFORT TO ADDRESS THE COVID-19 HEALTH CRISIS. SUB00002163 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST AND BROADLY PROTECTIVE IMMU View parent award on USAspending | — | $2,787,522 | Dec 10, 2021 | — – — |
| Subcontractor | Department of Health and Human Services | TASK/PROJECT SCOPE: THE SCOPE OF THIS TASK IS TO MODEL IMMUNE RESPONSES TO INFLUENZA VACCINE IN A PREVIOUSLY UNVACCINATED INDIGENOUS POPULATION IN COLOMBIA AND DETERMINE THE
PREVALENCE OF INFECTION BETWEEN VACCINATED AND NON-VACCINATED PEOPLE. DURING THE PREVIOUS CONTRACT PERIOD, WE ESTABLISHED A STRONG COLLABORATION WITH THE ARHUACO COMMUNITY AT
NABUSIMAKE AND STAFFED A COMMUNITY FEVER CLINIC. THIS IS THE SOLE SOURCE OF MEDICAL CARE FOR THE INDIGENOUS COMMUNITY OF > 4,500 PEOPLE WITH 70 €€Œ 100 PEOPLE PER MONTH SEEKING MEDICAL
CARE DUE TO RESPIRATORY/FEBRILE ILLNESS. WE DEMONSTRATED THAT HUMAN (AND ANIMAL) INFLUENZA VIRUSES WERE CIRCULATING IN THE COMMUNITY AND IDENTIFIED AN INFLUENZA B OUTBREAK IN 2017 THAT
RESULTED IN SIGNIFICANT MORTALITY, ESPECIALLY IN CHILDREN, FOLLOWED BY A MEASLES OUTBREAK. DUE TO
THESE EVENTS, THE COMMUNITY REQUESTED THAT WE BEGIN OFFERING VACCINES PROVIDING AN OPPORTUNITY TO EVALUATE THE IMMUNE RESPONSES IN A PREVIOUSLY UNVACCINATED POPULATION OF
CHILDREN AND ADULTS. IN RESPONSE, WE WILL ENROLL 100 PEOPLE EACH YEAR WHO WILL BE VACCINATED
WITH SEASONAL TIV/QIV. BLOOD (VOLUME DEPENDENT ON AGE) WILL BE COLLECTED FROM EACH SUBJECT AT THE TIME OF VACCINATION (D0) AND COLLECTED AGAIN 21€€Œ28 DAYS (D28), AROUND DAY 90-120
(D90) AND 1-YEAR POST-VACCINATION. ENROLLEES WILL BE ASKED TO COME TO THE CLINIC IF THEY EXPERIENCE ILI. IF THEY MEET THE WHO DEFINITION OF ILI, NASAL AND THROAT SWABS WILL BE COLLECTED
AND TESTED FOR INFLUENZA BY RAPID TEST OR QRT-PCR. THE PREVALENCE OF INFLUENZA VIRUS BETWEEN
VACCINATED AND NON-VACCINATED PEOPLE CAN BE COMPARED. ALL SAMPLES HAVE BEEN AND WILL BE CONSENTED FOR BANKING, FUTURE USE AND DISTRIBUTION, TESTING FOR OTHER PATHOGENS AND GENETIC
TESTING. A RISK FACTOR QUESTIONNAIRE WITH INFORMATION ON NUTRITIONAL STATUS, CONTACT WITH ANIMALS, UNDERLYING CO-MORBIDITIES, AND CONTACT WITH NON-INDIGENOUS POPULATIONS WILL ALSO BE
COMPLETED. WE WILL HARMONIZE OUR STUDIES WITH HUMAN COHORT 4 (INDIGENOUS POPULATIONS IN AUSTRALIA) TO ALLOW THE RESULTS TO BE ANALYZED TOGETHER SUB00002586 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $90,284 | Oct 15, 2021 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Health and Human ServicesGov-sourced