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CHILDREN'S HOSPITAL CORPORATION, THE
BOSTON, MA, 02115
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Prime contracting experience
17 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | SURVEILLANCE OF SEVERE IAE AND RELATED COMPLICATIONS IN US CHILDREN EO 14398 | — | $671,228 | Sep 24, 2026 | Sep 25, 2026 – Sep 24, 2027 |
| Prime | Department of Health and Human Services National Institutes of Health | VACCINES ADJUVANT DEVELOPMENT PROGRAM IN INFECTIOUS AND IMMUNE MEDIATED DISEASES | — | $6,042,313 | Aug 18, 2026 | Sep 30, 2023 – Sep 29, 2027 |
| Prime | Department of Health and Human Services National Institutes of Health | VACCINE ADJUVANT DISCOVERY PROGRAM (VADP) | — | $2,547,484 | Jul 14, 2026 | Sep 30, 2024 – Sep 29, 2027 |
| Prime | Department of Health and Human Services National Institutes of Health | TO DEVELOP INNOVATIVE AND SAFE MULTIVALENT ANTI-OPIOID VACCINES THAT PROTECT AGAINST HEROIN AND FENTANYL. | — | $19,894,862 | Jul 10, 2026 | Sep 30, 2020 – Sep 29, 2027 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | COVID-19 & MIS-C VE STUDY | — | $24,899,419 | Jun 9, 2026 | Aug 3, 2022 – Sep 15, 2026 |
| Prime | Department of Health and Human Services National Institutes of Health | TO IDENTIFY NOVEL ADJUVANT CANDIDATES THAT CAN BE USED TO AUGMENT THE EFFICACY OF HUMAN VACCINES. | — | $10,978,172 | Nov 25, 2025 | Sep 30, 2019 – Dec 29, 2025 |
| Prime | Department of Health and Human Services National Institutes of Health | IGF::OT::IGF ADJUVANT DEVELOPMENT PROGRAM | — | $13,579,975 | Sep 25, 2025 | Sep 30, 2018 – Nov 29, 2025 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | COMMUNITY FINDER PLATFORM | — | $20,360,884 | Sep 18, 2025 | Feb 1, 2023 – Jul 31, 2025 |
| Prime | Department of Health and Human Services Office of the Assistant Secretary for Administration | BASE YEAR - MOTHER-INFANT DYAD PROJECT | — | $450,000 | Aug 25, 2025 | Sep 30, 2022 – Sep 29, 2025 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | SCIENTIFIC STUDY | — | $3,612,349 | Mar 5, 2025 | Mar 31, 2023 – Mar 30, 2025 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | FLUMED IGF::OT::IGF FOR OTHER FUNCTIONS | — | $31,261,573 | Jul 10, 2024 | Jul 31, 2017 – Jan 30, 2023 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | COVID-19 IN CRITICALLY ILL CHILDREN | — | $5,092,787 | May 31, 2024 | Apr 8, 2020 – Oct 7, 2021 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | OUTBREAKS NEAR ME AND MONITORING TRENDS IN HEALTHCARE UTILIZATION AND LABORATORY | — | $491,152 | Mar 30, 2024 | Jul 13, 2021 – Jan 11, 2023 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | FLU NEAR YOU AND NOVEL DATA STREAMS TO SUPPLEMENT HEALTHCARE UTILIZATION SURVEILLANCE | — | $279,764 | May 9, 2023 | Apr 6, 2020 – Apr 5, 2021 |
| Prime | Department of Health and Human Services National Institutes of Health | IGF::OT::IGF ADJUVANT DISCOVERY PROGRAM | — | $10,416,028 | May 4, 2023 | Sep 23, 2014 – Aug 31, 2023 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | MIS-C IN CHILDREN | — | $9,990,605 | Nov 17, 2022 | May 5, 2021 – May 4, 2022 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | INFLUENZA VACCINE EFFECTIVENESS FOR CHILDREN IN THE US | — | $1,936,129 | Feb 15, 2022 | Jul 11, 2019 – Jul 9, 2021 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
21 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00003431 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $700,272 | Apr 16, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $185,417 | Mar 12, 2026 | — – — |
| Subcontractor | Department of Energy | BOSTON CHILDRENS HOSPITAL-STAND ALONE AGREEMENT-ITEM LEVEL-R AND D CW120462 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: NM Parent award description: IGF::CL::IGF COMPETITION FOR MANAGEMENT AND OPERATION OF LOS ALAMOS NATIONAL LABORATORY View parent award on USAspending | — | $1,997,578 | Jan 6, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $181,896 | Apr 3, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $459,698 | Mar 26, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | THE CHILDREN’S HOSPITAL CORPORATION D/B/A BOSTON CHILDREN’S HOSPITAL WILL SUPPORT “NEURODEVELOPMENTAL AND MENTAL HEALTH OUTCOMES IN PRETERM INFANTS: EFFECTS OF EXPOSURES TO OPIOID ANALGESIC, ANESTHETIC AND SEDATIVE AGENTS.” THE PROJECT WILL USE RETROSPECTIVE COHORT DATA FROM CUIMC, BOSTON CHILDREN’S, AND KAISER PERMANENTE NORTHERN CALIFORNIA TO PROVIDE FOUNDATIONAL INFORMATION FOR STUDIES ON NEURODEVELOPMENTAL AND MENTAL-HEALTH OUTCOMES IN PRETERM INFANTS EXPOSED TO OPIOID ANALGESIC, SEDATIVE, AND ANESTHETIC AGENTS. BOSTON CHILDREN’S WILL CONTRIBUTE EHR DATA FOR PRETERM-BIRTH, NICU PRETERM, AND SURGICAL PRETERM COHORTS; SUPPORT DATA EXTRACTION AND ANALYSIS OF DRUG-EXPOSURE PROFILES AND OUTCOMES; AND CONTRIBUTE TO STAKEHOLDER CONSENSUS AND FUTURE STUDY DESIGN. 1(GG018728-01) · Prime awardUSAspending | — | $225,162 | Feb 5, 2025 | — – — |
| Subcontractor | Department of Defense | R&D-SCHOOLS, NON-MIT 7000625253 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541712 Parent award performance state: MA Parent award description: IGF::CT::IGF TASK ORDER 0001 FOR DOD LINE FUNDING View parent award on USAspending | FA870215D0001USAspending | $50,000 | Dec 18, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $809,306 | Oct 29, 2024 | — – — |
| Subcontractor | Department of Defense | R&D-SCHOOLS, NON-MIT 7000625253 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541712 Parent award performance state: MA Parent award description: IGF::CT::IGF TASK ORDER 0001 FOR DOD LINE FUNDING View parent award on USAspending | FA870215D0001USAspending | $30,000 | Aug 15, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $178,476 | Jun 11, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH SUB00003431 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $699,698 | Apr 24, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | CENTER FOR INFLUENZA DISEASE AND EMERGENCE RESEARCH (CIDER) SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | -$13,500 | Mar 26, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | IN THIS PROJECT, WE BUILD ON PAST FDA FUNDED WORK THAT HAS LED TO THE DEVELOPMENT OF NEW ORGAN-ON-A-CHIP (ORGAN CHIP) MICROFLUIDIC CULTURE DEVICES AS PRECLINICAL TOOLS FOR EVALUATION OF EFFICACY AND SAFETY OF RADIATION MEDICAL COUNTER MEASURES (MCMS), INCLUDING THOSE FOR ACUTE RADIATION SYNDROME.THE MAJOR TASKS ARE TO: 1) TEST THE EFFECTS OF RADIATION MCMS IN THE HUMAN BONE MARROW CHIP RADIOTOXICITY MODEL, 2) EVALUATE THE ROLE OF GUT MICROBIOME IN HUMAN RADIATION INJURY, 3) RECAPITULATE RADIATION-INDUCED PNEUMONITIS IN HUMAN LUNG ALVEOLUS CHIP, AND 4) LEVERAGE THESE IN VITRO MODELS TO DISCOVER NEW RADIATION MCMS. ALL ORGAN CHIPS (BONE MARROW, INTESTINE, AND LUNG) WILL BE EXPOSED TO RADIATION AT BOSTON CHILDREN'S HOSPITAL (BCH), AND EXPERIMENTAL HANDLING OF CHIPS IMMEDIATELY PRIOR AND AFTER EXPOSURE WILL BE CARRIED OUT IN OUR BCH LABORATORY TO ENSURE WE ANALYZE IMMEDIATE AND RAPID RESPONSES AS WELL AS LONGER-TERM BIOLOGICAL EFFECTS AFTER EXPOSURE. THE RADIATION-PNEUMONITIS MODEL IN HUMAN LUNG ALVEOLUS CHIP WILL ALSO BE DEVELOPED, OPTIMIZED, AND STUDIED IN THE BCH LABORATORY WHERE CLINICAL EXPERTS IN LUNG INJURY ARE LOCATED. 168024-5115812 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541690 Parent award performance state: MA Parent award description: BAA MCMWP #71 "HUMAN ORGAN CHIPS FOR RADIATION COUNTERMEASURE DEVELOPMENT" View parent award on USAspending | — | $0 | Oct 19, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | IN THIS PROJECT, WE BUILD ON PAST FDA FUNDED WORK THAT HAS LED TO THE DEVELOPMENT OF NEW ORGAN-ON-A-CHIP (ORGAN CHIP) MICROFLUIDIC CULTURE DEVICES AS PRECLINICAL TOOLS FOR EVALUATION OF EFFICACY AND SAFETY OF RADIATION MEDICAL COUNTER MEASURES (MCMS), INCLUDING THOSE FOR ACUTE RADIATION SYNDROME.THE MAJOR TASKS ARE TO: 1) TEST THE EFFECTS OF RADIATION MCMS IN THE HUMAN BONE MARROW CHIP RADIOTOXICITY MODEL, 2) EVALUATE THE ROLE OF GUT MICROBIOME IN HUMAN RADIATION INJURY, 3) RECAPITULATE RADIATION-INDUCED PNEUMONITIS IN HUMAN LUNG ALVEOLUS CHIP, AND 4) LEVERAGE THESE IN VITRO MODELS TO DISCOVER NEW RADIATION MCMS. ALL ORGAN CHIPS (BONE MARROW, INTESTINE, AND LUNG) WILL BE EXPOSED TO RADIATION AT BOSTON CHILDREN'S HOSPITAL (BCH), AND EXPERIMENTAL HANDLING OF CHIPS IMMEDIATELY PRIOR AND AFTER EXPOSURE WILL BE CARRIED OUT IN OUR BCH LABORATORY TO ENSURE WE ANALYZE IMMEDIATE AND RAPID RESPONSES AS WELL AS LONGER-TERM BIOLOGICAL EFFECTS AFTER EXPOSURE. THE RADIATION-PNEUMONITIS MODEL IN HUMAN LUNG ALVEOLUS CHIP WILL ALSO BE DEVELOPED, OPTIMIZED, AND STUDIED IN THE BCH LABORATORY WHERE CLINICAL EXPERTS IN LUNG INJURY ARE LOCATED. 168024-5115812 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541690 Parent award performance state: MA Parent award description: BAA MCMWP #71 "HUMAN ORGAN CHIPS FOR RADIATION COUNTERMEASURE DEVELOPMENT" View parent award on USAspending | — | $186,066 | Aug 11, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | PARTICIPATE IN CLINICAL PROTOCOL AND SITE DEVELOPMENT TELECONFERENCES; COLLECT AND PROVIDE TO UAB CENTRAL UNIT ALL SUPPORTING REGULATORY DOCUMENTS FOR CONDUCTING THE STUDY; COMPLETE NECESSARY TRAINING; PROVIDE IRB DOCUMENTATION TO UAB CENTRAL UNIT; BEGIN, TRACK, AND DOCUMENT PATIENT SCREENING AND ENROLLMENT OF SUBJECTS IN ACCORDANCE WITH THE MOST CURRENT APPROVED PROTOCOL; COMPLETE STUDY REQUIRED CLINICAL PROCEDURES; COMPLETE FINAL CLINICAL STUDY PROCEDURES AND FOLLOW-UP FOR ENROLLED SUBJECTS IN ACCORDANCE WITH THE PROTOCOL; SUBMIT ALL REQUIRED DATA TO UAB; AND COMPLETE FINAL CLOSEOUT ACTIVITIES. 000509734-SC018-BEN-A02 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541712 Parent award performance state: AL Parent award description: IGF::OT::IGF - TARGETED CLINICAL RESEARCH TO ADDRESS SELECT VIRAL INFECTIONS View parent award on USAspending | — | $25,750 | Jun 8, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | IN THIS PROJECT, WE BUILD ON PAST FDA FUNDED WORK THAT HAS LED TO THE DEVELOPMENT OF NEW ORGAN-ON-A-CHIP (ORGAN CHIP) MICROFLUIDIC CULTURE DEVICES AS PRECLINICAL TOOLS FOR EVALUATION OF EFFICACY AND SAFETY OF RADIATION MEDICAL COUNTER MEASURES (MCMS), INCLUDING THOSE FOR ACUTE RADIATION SYNDROME.THE MAJOR TASKS ARE TO: 1) TEST THE EFFECTS OF RADIATION MCMS IN THE HUMAN BONE MARROW CHIP RADIOTOXICITY MODEL, 2) EVALUATE THE ROLE OF GUT MICROBIOME IN HUMAN RADIATION INJURY, 3) RECAPITULATE RADIATION-INDUCED PNEUMONITIS IN HUMAN LUNG ALVEOLUS CHIP, AND 4) LEVERAGE THESE IN VITRO MODELS TO DISCOVER NEW RADIATION MCMS. ALL ORGAN CHIPS (BONE MARROW, INTESTINE, AND LUNG) WILL BE EXPOSED TO RADIATION AT BOSTON CHILDREN'S HOSPITAL (BCH), AND EXPERIMENTAL HANDLING OF CHIPS IMMEDIATELY PRIOR AND AFTER EXPOSURE WILL BE CARRIED OUT IN OUR BCH LABORATORY TO ENSURE WE ANALYZE IMMEDIATE AND RAPID RESPONSES AS WELL AS LONGER-TERM BIOLOGICAL EFFECTS AFTER EXPOSURE. THE RADIATION-PNEUMONITIS MODEL IN HUMAN LUNG ALVEOLUS CHIP WILL ALSO BE DEVELOPED, OPTIMIZED, AND STUDIED IN THE BCH LABORATORY WHERE CLINICAL EXPERTS IN LUNG INJURY ARE LOCATED. 168024-5115812 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541690 Parent award performance state: MA Parent award description: BAA MCMWP #71 "HUMAN ORGAN CHIPS FOR RADIATION COUNTERMEASURE DEVELOPMENT" View parent award on USAspending | — | $0 | May 18, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE SUB00002584 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: GA Parent award description: UGA CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE View parent award on USAspending | — | $175,157 | May 12, 2023 | — – — |
| Subcontractor | Department of the Interior | THE PERSONAL RESPONSIBILITY EDUCATION
PROGRAM (PREP) LOCAL EVALUATION SUPPORT AND DISSEMINATION PROJECT INCLUDES PROVIDING LOCAL
EVALUATION SUPPORT TO PREIS, TRIBAL PREP, STATE PREP, AND COMPETITIVE PREP GRANTEES AND CONDUCTING
DISSEMINATION ACTIVITIES. 54431 Parent award context Parent award agency: Department of the Interior · Departmental Offices Parent award NAICS: 541611 Parent award performance state: MD Parent award description: PERSONAL RESPONSIBILITY EDUCATION PROGRAM (PREP) LOCAL EVALUATION SUPPORT AND DISSEMINATION View parent award on USAspending | GS00F252CAUSAspending | $373,420 | Jan 20, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | IN THIS PROJECT, WE BUILD ON PAST FDA FUNDED WORK THAT HAS LED TO THE DEVELOPMENT OF NEW ORGAN-ON-A-CHIP (ORGAN CHIP) MICROFLUIDIC CULTURE DEVICES AS PRECLINICAL TOOLS FOR EVALUATION OF EFFICACY AND SAFETY OF RADIATION MEDICAL COUNTER MEASURES (MCMS), INCLUDING THOSE FOR ACUTE RADIATION SYNDROME.THE MAJOR TASKS ARE TO: 1) TEST THE EFFECTS OF RADIATION MCMS IN THE HUMAN BONE MARROW CHIP RADIOTOXICITY MODEL, 2) EVALUATE THE ROLE OF GUT MICROBIOME IN HUMAN RADIATION INJURY, 3) RECAPITULATE RADIATION-INDUCED PNEUMONITIS IN HUMAN LUNG ALVEOLUS CHIP, AND 4) LEVERAGE THESE IN VITRO MODELS TO DISCOVER NEW RADIATION MCMS. ALL ORGAN CHIPS (BONE MARROW, INTESTINE, AND LUNG) WILL BE EXPOSED TO RADIATION AT BOSTON CHILDREN'S HOSPITAL (BCH), AND EXPERIMENTAL HANDLING OF CHIPS IMMEDIATELY PRIOR AND AFTER EXPOSURE WILL BE CARRIED OUT IN OUR BCH LABORATORY TO ENSURE WE ANALYZE IMMEDIATE AND RAPID RESPONSES AS WELL AS LONGER-TERM BIOLOGICAL EFFECTS AFTER EXPOSURE. THE RADIATION-PNEUMONITIS MODEL IN HUMAN LUNG ALVEOLUS CHIP WILL ALSO BE DEVELOPED, OPTIMIZED, AND STUDIED IN THE BCH LABORATORY WHERE CLINICAL EXPERTS IN LUNG INJURY ARE LOCATED. 168024-5115812 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541690 Parent award performance state: MA Parent award description: BAA MCMWP #71 "HUMAN ORGAN CHIPS FOR RADIATION COUNTERMEASURE DEVELOPMENT" View parent award on USAspending | — | $160,000 | Jun 10, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | IN THIS PROJECT, WE BUILD ON PAST FDA FUNDED WORK THAT HAS LED TO THE DEVELOPMENT OF NEW ORGAN-ON-A-CHIP (ORGAN CHIP) MICROFLUIDIC CULTURE DEVICES AS PRECLINICAL TOOLS FOR EVALUATION OF EFFICACY AND SAFETY OF RADIATION MEDICAL COUNTER MEASURES (MCMS), INCLUDING THOSE FOR ACUTE RADIATION SYNDROME.THE MAJOR TASKS ARE TO: 1) TEST THE EFFECTS OF RADIATION MCMS IN THE HUMAN BONE MARROW CHIP RADIOTOXICITY MODEL, 2) EVALUATE THE ROLE OF GUT MICROBIOME IN HUMAN RADIATION INJURY, 3) RECAPITULATE RADIATION-INDUCED PNEUMONITIS IN HUMAN LUNG ALVEOLUS CHIP, AND 4) LEVERAGE THESE IN VITRO MODELS TO DISCOVER NEW RADIATION MCMS. ALL ORGAN CHIPS (BONE MARROW, INTESTINE, AND LUNG) WILL BE
EXPOSED TO -RADIATION AT BOSTON CHILDREN'S HOSPITAL (BCH), AND EXPERIMENTAL HANDLING OF CHIPS IMMEDIATELY PRIOR AND AFTER EXPOSURE WILL BE CARRIED OUT IN OUR BCH LABORATORY TO ENSURE WE ANALYZE IMMEDIATE AND RAPID RESPONSES AS WELL AS LONGER-TERM BIOLOGICAL EFFECTS AFTER EXPOSURE. THE RADIATION-PNEUMONITIS MODEL IN HUMAN LUNG ALVEOLUS CHIP WILL ALSO BE DEVELOPED, OPTIMIZED, AND STUDIED IN THE BCH LABORATORY WHERE CLINICAL EXPERTS IN LUNG INJURY ARE LOCATED. 168024-5115812 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541690 Parent award performance state: MA Parent award description: BAA MCMWP #71 "HUMAN ORGAN CHIPS FOR RADIATION COUNTERMEASURE DEVELOPMENT" View parent award on USAspending | — | $166,024 | May 4, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | PREVENTABLE HARM FROM PEDIATRIC OUTPATIENT MEDICATION ERRORS: MEASURE DEVELOPMENT 313516 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541715 Parent award performance state: MD Parent award description: BAA 159 PREVENTABLE HARM FROM PEDIATRIC OUTPATIENT MEDICATION ERRORS MEASURE DEVELOPMENT View parent award on USAspending | — | $54,512 | Nov 24, 2021 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Health and Human ServicesGov-sourced
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.