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AFRICA HEALTH RESEARCH INSTITUTE NPC
DURBAN
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Subcontracting experience
5 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | AFRICA HEALTH RESEARCH INSTITUTE (AHRI) WILL CONDUCT GLOBAL MOLECULAR MEASUREMENTS ON TB CASES AND CONTROLS IN THE VUKUZAZI COHORT TO DEFINE CORRELATES OF PROTECTION AND TEST HYPOTHESIZED MECHANISMS OF PROTECTION ARISING FROM WITHIN THE CENTER OR OTHER PROGRAMS (YEARS 2-7).
IN YEAR 4, AHRI WILL SPECIFICALLY:
ACTIVITY 1: IDENTIFY EARLY TB CASES AND MTB-INFECTED UNDISEASED CONTROLS FROM PARTICIPANTS IN THE VUKUZAZI COHORT.
ACTIVITY 2: IDENTIFY LATE TB CASES AND MTB-INFECTED UNDISEASED CONTROLS FROM PARTICIPANTS IN THE VUKUZAZI COHORT.
ACTIVITY 3: CONDUCT TRANSCRIPTIONAL ANALYSIS ON WHOLE-BLOOD FROM TB CASES AND MATCHED CONTROLS IN THE VUKUZAZI STUDY.
€ƒ 12928SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $936,063 | Sep 2, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | AFRICA HEALTH RESEARCH INSTITUTE (AHRI) WILL CONDUCT GLOBAL MOLECULAR MEASUREMENTS ON TB CASES AND CONTROLS IN THE VUKUZAZI COHORT TO DEFINE CORRELATES OF PROTECTION AND TEST HYPOTHESIZED MECHANISMS OF PROTECTION ARISING FROM WITHIN THE CENTER OR OTHER PROGRAMS (YEARS 2-7).
IN YEAR 5, AHRI WILL SPECIFICALLY:
ACTIVITY 1: IDENTIFY EARLY TB CASES AND MTB-INFECTED UNDISEASED CONTROLS FROM PARTICIPANTS IN THE VUKUZAZI COHORT.
ACTIVITY 2: IDENTIFY LATE TB CASES AND MTB-INFECTED UNDISEASED CONTROLS FROM PARTICIPANTS IN THE VUKUZAZI COHORT.
ACTIVITY 3: CONDUCT TRANSCRIPTIONAL ANALYSIS ON WHOLE-BLOOD FROM TB CASES AND MATCHED CONTROLS IN THE VUKUZAZI STUDY.
ACTIVITY 4: CONDUCT COMPUTATIONAL ANALYSES TO IDENTIFY NOVEL CORRELATES OF PROTECTION AND TEST PREDICTED CORRELATES OF PROTECTION. 13209SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $24,716 | Aug 28, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | AS PART OF THE HARVARD IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS (IMPACTB) CENTER, THE LABORATORY OF EMILY WONG WILL LEAD AND PERFORM WORK UNDER THE PROGRAM€„¢S OPTION: IDENTIFICATION OF CROSS-SPECIES TRANSLATABLE DETERMINANTS OF TB PHENOTYPES.
SPECIFICALLY, DR. WONG WILL:
. LEAD THE ANALYSIS OF MTB RESPONSES IN PATIENTS FROM THE VUKUZAZI COMMUNITY HEALTH PROGRAM.
. WORK CLOSELY WITH THE SASSETTI, FLYNN AND LAUFFENBURGER LABS TO IDENTIFY HARMONIZED MTB DISEASE STATES IN ANIMAL STUDIES THAT ARE RELEVANT WITH THE SPECTRUM OF MTB INFECTION IN HUMANS.
. CONDUCT RNA-SEQUENCING OF BANKED HUMAN BLOOD SAMPLES
. PARTICIPATE IN CROSS-SPECIES ANALYSIS OF IMMUNE PROCESSES ASSOCIATED WITH HUMAN TB DISEASE OUTCOMES.
. MEET THE DELIVERABLES SET FORTH IN THE IMPACTB STATEMENT OF WORK. 109786-5125087 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: MA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $0 | Aug 23, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | AS PART OF THE HARVARD IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS (IMPACTB) CENTER, THE LABORATORY OF EMILY WONG WILL LEAD AND PERFORM WORK UNDER THE PROGRAM€„¢S OPTION: IDENTIFICATION OF CROSS-SPECIES TRANSLATABLE DETERMINANTS OF TB PHENOTYPES.
SPECIFICALLY, DR. WONG WILL:
€¢ LEAD THE ANALYSIS OF MTB RESPONSES IN PATIENTS FROM THE VUKUZAZI COMMUNITY HEALTH PROGRAM.
€¢ WORK CLOSELY WITH THE SASSETTI, FLYNN AND LAUFFENBURGER LABS TO IDENTIFY HARMONIZED MTB DISEASE STATES IN ANIMAL STUDIES THAT ARE RELEVANT WITH THE SPECTRUM OF MTB INFECTION IN HUMANS.
€¢ CONDUCT RNA-SEQUENCING OF BANKED HUMAN BLOOD SAMPLES
€¢ PARTICIPATE IN CROSS-SPECIES ANALYSIS OF IMMUNE PROCESSES ASSOCIATED WITH HUMAN TB DISEASE OUTCOMES.
€¢ MEET THE DELIVERABLES SET FORTH IN THE IMPACTB STATEMENT OF WORK, AS LISTED BELOW.
SCIENTIFIC GOAL: CROSS-SPECIES MODELING OF MOUSE, NHP AND HUMAN DATASETS ACROSS THE SPECTRUM OF MTB DISEASE
DELIVERABLES:
-IDENTIFY AND CURATE A PANEL OF BLOOD SAMPLES FROM THE VUKUZAZKI COHORT THAT SPANS THE SPECTRUM OF HUMAN DISEASE
-CURATE PAIRED DATASETS OF CLINICAL OUTCOMES ASSOCIATED WITH EACH RNA SEQUENCING PARTICIPANT
-COLLECT RNA PAXGENE SAMPLE AND DATA FROM MATCHED COMPARISON GROUP WITH CLINICAL TB
-COMPLETE RNA SEQUENCING OF ALL BLOOD SAMPLES.
-TRANSFER HUMAN OUTCOME DATE AND PAIRED RNA-SEQUENCING DATASETS TO LAUFFENBURGER LAB FOR INTEGRATIVE MODELING 109786.5125087 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: MA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $324,718 | Dec 1, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | AHRI WILL CONDUCT GLOBAL MOLECULAR MEASUREMENTS ON TB CASES AND CONTROLS IN THE VUKUZAZI COHORT TO DEFINE CORRELATES OF PROTECTION AND TEST HYPOTHESIZED MECHANISMS OF PROTECTION ARISING FROM WITHIN THE CENTER OR OTHER PROGRAMS (YEARS 2-7). IN YEAR 3 WE WILL SPECIFICALLY:
ACTIVITY 1: IDENTIFY EARLY TB CASES AND MTB-INFECTED UNDISEASED CONTROLS FROM PARTICIPANTS IN THE VUKUZAZI COHORT.
ACTIVITY 2: IDENTIFY LATE TB CASES AND MTB-INFECTED UNDISEASED CONTROLS FROM PARTICIPANTS IN THE VUKUZAZI COHORT.
ACTIVITY 3: CONDUCT TRANSCRIPTIONAL ANALYSIS ON WHOLE-BLOOD FROM TB CASES AND MATCHED CONTROLS IN THE VUKUZAZI STUDY. 12708SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: WA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $1,030,951 | May 31, 2022 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
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