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RHODE ISLAND HOSPITAL
PROVIDENCE, RI, 02903
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Prime contracting experience
1 record from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | MICROBIOME DISRUPTION INDICES | — | $451,513 | Oct 29, 2021 | Sep 20, 2016 – Sep 14, 2017 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
15 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | PNEUMONIA IS A COMMON CLINICAL DIAGNOSIS THAT OFTEN LACKS A MICROBIOLOGICAL DIAGNOSIS BECAUSE NO PATHOGEN IS IDENTIFIED. WITHOUT A MICROBIOLOGICAL DIAGNOSIS, ANTIBIOTICS TARGETING A BROAD RANGE OF PATHOGENS ARE USED, INCREASING THE RISKS FOR RESISTANCE ALONG WITH POOR OUTCOMES IF INAPPROPRIATE ANTIBIOTICS ARE CHOSEN. THIS RESEARCH PROGRAM PROPOSES TO DIAGNOSE LOWER RESPIRATORY TRACT BACTERIAL INFECTIONS AND THEIR ASSOCIATED ANTIMICROBIAL RESISTANCE IN FOUR HOURS, MUCH FASTER THAN CURRENT CULTURE TECHNIQUES. THE LONG-TERM GOAL OF THIS RESEARCH PROGRAM IS TO DEVELOP RAPID DIAGNOSTIC TESTS THAT WILL BE INDICATED IN ALL PATIENTS WITH A CLINICAL SUSPICION FOR PNEUMONIA. THE SHORT-TERM OBJECTIVE WILL FOCUS ON PNEUMONIAS CAUSED BY STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA, AND HAEMOPHILUS INFLUENZAE, WITH THE GOAL OF HAVING RESULTS AVAILABLE IN 4 HOURS. THE STRATEGY USED IN THIS DIAGNOSTIC TEST DISTINGUISHES IT FROM COMPETITORS AND ALTERNATIVES. THIS DIAGNOSTIC IS BASED ON DETECTING RNA SEQUENCE(S) SPECIFIC FOR THE PATHOGEN CAUSING PNEUMONIA IN A HUMAN PATIENT. TESTING WILL BE DONE ON BLOOD DRAWN DIRECTLY FROM THE PATIENT, MAKING IT LESS INVASIVE THAN OTHER METHODS THAT OBTAIN SAMPLES FROM THE AIRWAYS, SUCH AS BRONCHOSCOPY OR DEEP SUCTIONING. THIS TEST WILL NOT REQUIRE THE SPECIMEN TO BE CULTURED, ALLOWING FOR FASTER RESULTS THAN TRADITIONAL MICROBIOLOGICAL METHODS. THE RNA TARGETED BY THE TEST IS IDENTIFIED VIA RNA SEQUENCING OF BLOOD FROM PATIENTS WITH THE INFECTION. RNA SEQUENCING DATA SHOWS RNA SPECIFIC TO THE PATHOGEN OF INTEREST (S. AUREUS., P. AERUGINOSA, AND H. INFLUENZAE) THAT IS ALSO SPECIFIC FOR AN ACTIVE INFECTION. TARGETING RNA ALSO ENSURES THAT THE INFECTION IS CURRENT SINCE RNA IS LESS STABLE THAN DNA, LASTING MINUTES TO HOURS WHEN FROM A BACTERIUM. THE METHOD, HOWEVER, IMMEDIATELY STABILIZES THE RNA FOR TESTING. RNA ALSO IDENTIFIES BACTERIA THAT ARE ACTIVELY MAKING RESISTANCE PROTEINS, RATHER THAN BACTERIA WITH THE POTENTIAL FOR RESISTANCE BASED ONLY ON GENOMIC DNA. AT THE END OF THIS PROJECT, PCR BASED TESTS WILL BE CREATED THAT ARE INFORMED BY RNA SEQUENCING DATA. THESE WILL DIAGNOSE PNEUMONIA DUE TO S. AUREUS., P. AERUGINOSA, AND H. INFLUENZAE, ALONG WITH RELEVANT ANTIBIOTIC RESISTANCE, USING BLOOD FROM THE PATIENT. THIS PCR TESTING PLATFORM USES FDA-APPROVED INSTRUMENTATION TO FACILITATE TRANSITIONING FROM A RESEARCH LABORATORY TO A CLINICAL MICROBIOLOGY LABORATORY. 4500005266 Parent award context Parent award agency: Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response Parent award NAICS: 541714 Parent award performance state: MA Parent award description: CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA View parent award on USAspending | — | -$99,937 | Feb 28, 2025 | — – — |
| Subcontractor | Department of Defense | PROCURED GOODS AND/OR SERVICES BETWEEN 09-SEP-24 AND 10-SEP-25 IN SUPPORT OF CONTRACT SOW. P010333221-0 Parent award context Parent award agency: Department of Defense · Department of the Navy Parent award NAICS: 541712 Parent award performance state: CA Parent award description: NON-SEVERABLE BEAR RSS View parent award on USAspending | GS00Q14OADU420USAspending | $45,723 | Jan 30, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | PNEUMONIA IS A COMMON CLINICAL DIAGNOSIS THAT OFTEN LACKS A MICROBIOLOGICAL DIAGNOSIS BECAUSE NO PATHOGEN IS IDENTIFIED. WITHOUT A MICROBIOLOGICAL DIAGNOSIS, ANTIBIOTICS TARGETING A BROAD RANGE OF PATHOGENS ARE USED, INCREASING THE RISKS FOR RESISTANCE ALONG WITH POOR OUTCOMES IF INAPPROPRIATE ANTIBIOTICS ARE CHOSEN. THIS RESEARCH PROGRAM PROPOSES TO DIAGNOSE LOWER RESPIRATORY TRACT BACTERIAL INFECTIONS AND THEIR ASSOCIATED ANTIMICROBIAL RESISTANCE IN FOUR HOURS, MUCH FASTER THAN CURRENT CULTURE TECHNIQUES. THE LONG-TERM GOAL OF THIS RESEARCH PROGRAM IS TO DEVELOP RAPID DIAGNOSTIC TESTS THAT WILL BE INDICATED IN ALL PATIENTS WITH A CLINICAL SUSPICION FOR PNEUMONIA. THE SHORT-TERM OBJECTIVE WILL FOCUS ON PNEUMONIAS CAUSED BY STAPHYLOCOCCUS AUREUS, PSEUDOMONAS AERUGINOSA, AND HAEMOPHILUS INFLUENZAE, WITH THE GOAL OF HAVING RESULTS AVAILABLE IN 4 HOURS. THE STRATEGY USED IN THIS DIAGNOSTIC TEST DISTINGUISHES IT FROM COMPETITORS AND ALTERNATIVES. THIS DIAGNOSTIC IS BASED ON DETECTING RNA SEQUENCE(S) SPECIFIC FOR THE PATHOGEN CAUSING PNEUMONIA IN A HUMAN PATIENT. TESTING WILL BE DONE ON BLOOD DRAWN DIRECTLY FROM THE PATIENT, MAKING IT LESS INVASIVE THAN OTHER METHODS THAT OBTAIN SAMPLES FROM THE AIRWAYS, SUCH AS BRONCHOSCOPY OR DEEP SUCTIONING. THIS TEST WILL NOT REQUIRE THE SPECIMEN TO BE CULTURED, ALLOWING FOR FASTER RESULTS THAN TRADITIONAL MICROBIOLOGICAL METHODS. THE RNA TARGETED BY THE TEST IS IDENTIFIED VIA RNA SEQUENCING OF BLOOD FROM PATIENTS WITH THE INFECTION. RNA SEQUENCING DATA SHOWS RNA SPECIFIC TO THE PATHOGEN OF INTEREST (S. AUREUS., P. AERUGINOSA, AND H. INFLUENZAE) THAT IS ALSO SPECIFIC FOR AN ACTIVE INFECTION. TARGETING RNA ALSO ENSURES THAT THE INFECTION IS CURRENT SINCE RNA IS LESS STABLE THAN DNA, LASTING MINUTES TO HOURS WHEN FROM A BACTERIUM. THE METHOD, HOWEVER, IMMEDIATELY STABILIZES THE RNA FOR TESTING. RNA ALSO IDENTIFIES BACTERIA THAT ARE ACTIVELY MAKING RESISTANCE PROTEINS, RATHER THAN BACTERIA WITH THE POTENTIAL FOR RESISTANCE BASED ONLY ON GENOMIC DNA. AT THE END OF THIS PROJECT, PCR BASED TESTS WILL BE CREATED THAT ARE INFORMED BY RNA SEQUENCING DATA. THESE WILL DIAGNOSE PNEUMONIA DUE TO S. AUREUS., P. AERUGINOSA, AND H. INFLUENZAE, ALONG WITH RELEVANT ANTIBIOTIC RESISTANCE, USING BLOOD FROM THE PATIENT. THIS PCR TESTING PLATFORM USES FDA-APPROVED INSTRUMENTATION TO FACILITATE TRANSITIONING FROM A RESEARCH LABORATORY TO A CLINICAL MICROBIOLOGY LABORATORY. 4500005266 Parent award context Parent award agency: Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response Parent award NAICS: 541714 Parent award performance state: MA Parent award description: CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA View parent award on USAspending | — | $549,654 | Dec 18, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | BROWN UNIVERSITY/RHODE ISLAND HOSPITAL OF WILL ASSIST THE CDC WITH ESTABLISHING A PLATFORM THAT INVOLVES A NETWORK OF NURSING HOMES WITH PRE-POSITIONED STUDY STAFF AND READILY AVAILABLE LABORATORY CAPACITY TO PERFORM DATA COLLECTION WITHOUT IMPACTING CLINICAL CARE TO RAPIDLY CHARACTERIZE INFECTIOUS DISEASES, PARTICULARLY EMERGING PATHOGENS AND SARS-COV-2 VARIANTS OF CONCERN, TO INFORM INFECTION PREVENTION AND CONTROL STRATEGIES IN NURSING HOMES. 54235 MOD 03 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541990 Parent award performance state: MD Parent award description: 2022 D1-A009 NURSING HOME PUBLIC HEALTH RESPONSE NETWORK View parent award on USAspending | 75D30121D12704USAspending | $49,422 | Sep 29, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | BROWN UNIVERSITY/RHODE ISLAND HOSPITAL OF WILL ASSIST THE CDC WITH ESTABLISHING A PLATFORM THAT INVOLVES A NETWORK OF NURSING HOMES WITH PRE-POSITIONED STUDY STAFF AND READILY AVAILABLE LABORATORY CAPACITY TO PERFORM DATA COLLECTION WITHOUT IMPACTING CLINICAL CARE TO RAPIDLY CHARACTERIZE INFECTIOUS DISEASES, PARTICULARLY EMERGING PATHOGENS AND SARS-COV-2 VARIANTS OF CONCERN, TO INFORM INFECTION PREVENTION AND CONTROL STRATEGIES IN NURSING HOMES. 54235 MOD 05 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541990 Parent award performance state: MD Parent award description: 2022 D1-A009 NURSING HOME PUBLIC HEALTH RESPONSE NETWORK View parent award on USAspending | 75D30121D12704USAspending | $399,999 | Sep 29, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | THE MYLONAKIS LAB WILL PROCESS CLINICAL SAMPLES AND SUBMIT THEM FOR FURTHER PROCESSING TO IDENTIFY HOSTPATHOGEN INTERACTIONS THAT ARE RELEVANT TO THE SCOPE OF THIS WORK. 00001851 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541712 Parent award performance state: RI Parent award description: SHEPHERD 2021 DOMAIN 3-C001 View parent award on USAspending | HHSD200201691773IUSAspending | $117,912 | Nov 17, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | BROWN UNIVERSITY/RHODE ISLAND HOSPITAL OF WILL ASSIST THE CDC WITH ESTABLISHING A PLATFORM THAT INVOLVES A NETWORK OF NURSING HOMES WITH PRE-POSITIONED STUDY STAFF AND READILY AVAILABLE LABORATORY CAPACITY TO PERFORM DATA COLLECTION WITHOUT IMPACTING CLINICAL CARE TO RAPIDLY CHARACTERIZE INFECTIOUS DISEASES, PARTICULARLY EMERGING PATHOGENS AND SARS-COV-2 VARIANTS OF CONCERN, TO INFORM INFECTION PREVENTION AND CONTROL STRATEGIES IN NURSING HOMES. 54235 MOD 02 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541990 Parent award performance state: MD Parent award description: 2022 D1-A009 NURSING HOME PUBLIC HEALTH RESPONSE NETWORK View parent award on USAspending | 75D30121D12704USAspending | $491,302 | Sep 30, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | BROWN UNIVERSITY/RHODE ISLAND HOSPITAL OF WILL ASSIST THE CDC WITH ESTABLISHING A PLATFORM THAT INVOLVES A NETWORK OF NURSING HOMES WITH PRE-POSITIONED STUDY STAFF AND READILY AVAILABLE LABORATORY CAPACITY TO PERFORM DATA COLLECTION WITHOUT IMPACTING CLINICAL CARE TO RAPIDLY CHARACTERIZE INFECTIOUS DISEASES, PARTICULARLY EMERGING PATHOGENS AND SARS-COV-2 VARIANTS OF CONCERN, TO INFORM INFECTION PREVENTION AND CONTROL STRATEGIES IN NURSING HOMES. 54235 MOD 01 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541990 Parent award performance state: MD Parent award description: 2022 D1-A009 NURSING HOME PUBLIC HEALTH RESPONSE NETWORK View parent award on USAspending | 75D30121D12704USAspending | $64,439 | Sep 11, 2023 | — – — |
| Subcontractor | Department of Defense | R&D-SCHOOLS, NON-MIT 7000559920 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541712 Parent award performance state: MA Parent award description: IGF::CT::IGF TASK ORDER 0001 FOR DOD LINE FUNDING View parent award on USAspending | FA870215D0001USAspending | $35,000 | Feb 9, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | BROWN UNIVERSITY/RHODE ISLAND HOSPITAL OF WILL ASSIST THE CDC WITH ESTABLISHING A PLATFORM THAT INVOLVES A NETWORK OF NURSING HOMES WITH PRE-POSITIONED STUDY STAFF AND READILY AVAILABLE LABORATORY CAPACITY TO PERFORM DATA COLLECTION WITHOUT IMPACTING CLINICAL CARE TO RAPIDLY CHARACTERIZE INFECTIOUS DISEASES, PARTICULARLY EMERGING PATHOGENS AND SARS-COV-2 VARIANTS OF CONCERN, TO INFORM INFECTION PREVENTION AND CONTROL STRATEGIES IN NURSING HOMES. 54235 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541990 Parent award performance state: MD Parent award description: 2022 D1-A009 NURSING HOME PUBLIC HEALTH RESPONSE NETWORK View parent award on USAspending | 75D30121D12704USAspending | $409,154 | Nov 21, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | THE MYLONAKIS LAB WILL PROCESS CLINICAL SAMPLES AND SUBMIT THEM FOR FURTHER PROCESSING TO IDENTIFY HOSTPATHOGEN INTERACTIONS THAT ARE RELEVANT TO THE SCOPE OF THIS WORK. 00001851 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541712 Parent award performance state: RI Parent award description: SHEPHERD 2021 DOMAIN 3-C001 View parent award on USAspending | HHSD200201691773IUSAspending | $653,111 | Oct 21, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | THE MYLONAKIS LAB WILL PROCESS CLINICAL SAMPLES AND SUBMIT THEM FOR FURTHER PROCESSING TO IDENTIFY HOSTPATHOGEN INTERACTIONS THAT ARE RELEVANT TO THE SCOPE OF THIS WORK. 00001851 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541712 Parent award performance state: RI Parent award description: SHEPHERD 2021 DOMAIN 3-C001 View parent award on USAspending | HHSD200201691773IUSAspending | $53,705 | Apr 25, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | THE MYLONAKIS LAB WILL PROCESS CLINICAL SAMPLES AND SUBMIT THEM FOR FURTHER PROCESSING TO IDENTIFY HOSTPATHOGEN INTERACTIONS THAT ARE RELEVANT TO THE SCOPE OF THIS WORK. 00001851 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541712 Parent award performance state: RI Parent award description: SHEPHERD 2021 DOMAIN 3-C001 View parent award on USAspending | HHSD200201691773IUSAspending | $443,444 | Feb 18, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | DR. CHUN WILL SERVE AS THE RHODE ISLAND HOSPITAL CO-INVESTIGATOR AND STUDY PHYSICIAN. 00001941 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: RI Parent award description: ALCOHOL CUE HUMAN LABORATORY STUDY TESTING ASP 8062 View parent award on USAspending | 75N94021D00004USAspending | $64,291 | Jan 19, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | €¢ KICKOFF MEETING (BY TELECONFERENCE)
O TWO HOURS
O JUSTIFICATION: REQUIRED FOR COMMUNICATION OF PROJECT GOALS AND EXPECTATION
€¢ ESTABLISHMENT OF THE SURVEILLANCE PROTOCOL AND CASE REPORT FORM INCLUDING RUDIMENTARY TEXT
IDENTIFICATION FOR VACCINATION STATUS.
O 140 HOURS (IT)+ 40 HOURS (PM)+ 11 HOURS {PL)
O JUSTIFICATION: SET-UP TIME AND EFFORT COSTS REQUIRED FOR INFORMATION TRANSFER FROM EACH SITE FOR ALL GOALS, WHICH REQUIRES FACE TO FACE MEETINGS, MULTIPLE ZOOM CALLS WITH THE PRIME SITE, AND MULTIPLE TEST RUNS. REQUIRED TO COMMUNICATE WITH OTHER SITES TO BALANCE
FEASIBILITY AND RIGOR
€¢ ESTABLISH OR AMEND AGREEMENTS WITH EDNS INSTITUTIONAL REVIEW BOARD {IRB) NON-RESEARCH N/A
€¢ REPORT ESTIMATES OF POPULATIONS SERVED BY EACH HOSPITAL/HOSPITAL NETWORK.
O TWO HOURS (PM+IT)
O JUSTIFICATION: REQUIRES SEVERAL MEETINGS TO ESTABLISH SEARCH PARAMETERS AND REVIEW
RESULTS
€¢ IRB APPROVAL OF THE SURVEILLANCE PROTOCOL.
O 20 HOURS. PROTOCOL PREPARATION, SUBMISSION AND REVISION.
O JUSTIFICATION: FOR ALL GOALS, EACH SITE WILL NEED TO MAINTAIN IDENTIFYING INFORMATION ON EACH PATIENT, AND THIS WILL REQUIRE FULL IRB REVIEW. DEVELOP OR MODIFY EXISTING DATA COLLECTION TOOLS AND PROTOCOLS TO SUPPORT THE DATA COLLECTION.
O TWO HOURS {PL+PM+IT)
O JUSTIFICATION: REQUIRED TO ESTABLISH FEASIBILITY OF ENSURING COMPLIANCE WITH FEDERAL RULES ON PRIVACY, WHILE ALLOWING LOCAL IDENTIFICATION, AND ENSURING INTERNAL SYSTEMS FOR SWAB TRANSFER TO APPROPRIATE AUTHORITIES
€¢ SUBMIT DRAFT DATA MANAGEMENT PLAN
O THREE HOURS (PL+PM)
O JUSTIFICATION: TWO ONE-HOUR ZOOM CALLS TO CREATE METHODS OF API EXTRACTION, DEFINITIONS OF DATA QUALITY, METHODOLOGY FOR TRAINING OF ABSTRACTORS FOR GOAL [6], METHODS FOR REAL TIME DATA COLLECTION IN GOAL [4], AND PROCEDURES FOR HANDLING OF MISSING DATA. WS22015 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541360 Parent award performance state: GA Parent award description: ENHANCING U.S. SURVEILLANCE OF LABORATORY CONFIRMED SARS-COV-2, INFLUENZA, AND OTHER RESPIRATORY VIRUSES View parent award on USAspending | — | $229,636 | Dec 3, 2021 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Health and Human ServicesGov-sourced
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.