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LA JOLLA INSTITUTE FOR IMMUNOLOGY
Doing business as LA JOLLA INSTITUTE FOR ALLERGY & IMMUNOLOGY
LA JOLLA, CA, 92037
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Prime contracting experience
10 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services National Institutes of Health | THE IDENTIFICATION AND VALIDATION OF EPITOPES CONSERVED IN VIRAL PATHOGEN FAMILIES WITH PANDEMIC POTENTIAL | — | $3,205,458 | Sep 3, 2026 | Sep 30, 2024 – Sep 29, 2027 |
| Prime | Department of Health and Human Services National Institutes of Health | IDENTIFICATION AND CHARACTERIZATION OF T CELL EPITOPES FROM BACTERIAL PATHOGENS CAUSING PNEUMONIA | — | $3,205,308 | Sep 3, 2026 | Sep 30, 2024 – Sep 29, 2027 |
| Prime | Department of Health and Human Services National Institutes of Health | IMMUNE EPITOPE DATABASE AND ANALYSIS PROGRAM | — | $3,576,859 | Aug 14, 2026 | Mar 15, 2026 – Mar 14, 2028 |
| Prime | Department of Health and Human Services National Institutes of Health | IGF::OT::IGF IMMUNE EPITOPE AND ANALYSIS PROGRAM | — | $24,260,098 | Dec 8, 2025 | Dec 15, 2018 – Mar 14, 2026 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | BAA TOPIC 22.3 - SYSTEMIC ASSESSMENT OF IMMUNITY TO B. PERTUSSIS USING VALIDATED ASSAYS & DATA INTEGRATION | — | $1,049,692 | Sep 11, 2024 | Sep 15, 2022 – Sep 14, 2025 |
| Prime | Department of Health and Human Services National Institutes of Health | LARGE SCALE T CELL EPITOPE DISCOVERY | — | $4,499,760 | Sep 13, 2023 | Sep 30, 2019 – Sep 29, 2024 |
| Prime | Department of Health and Human Services National Institutes of Health | LARGE SCALE T CELL EPITOPE DISCOVERY | — | $7,346,666 | Jul 31, 2023 | Sep 30, 2019 – Sep 29, 2024 |
| Prime | Department of Health and Human Services National Institutes of Health | LARGE SCALE T CELL EPITOPE DISCOVERY | — | $4,495,633 | Jul 21, 2023 | Sep 30, 2019 – Sep 29, 2024 |
| Prime | Department of Health and Human Services National Institutes of Health | R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH) | — | $25,502,625 | Mar 14, 2022 | Nov 10, 2011 – Dec 15, 2018 |
| Prime | Department of Defense Department of the Navy | RESEARCH - IMMUNOLOGIC CELL RESPONSES | — | $431,182 | Oct 18, 2021 | Jun 29, 2021 – Apr 30, 2022 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
7 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Energy | LA JOLLA INSTITUTE FOR IMMUNOLOGY CW142843 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: NM Parent award description: IGF::CL::IGF COMPETITION FOR MANAGEMENT AND OPERATION OF LOS ALAMOS NATIONAL LABORATORY View parent award on USAspending | — | $1,974,000 | Aug 4, 2026 | — – — |
| Subcontractor | Department of Energy | LA JOLLA INSTITUTE OF IMMUNOLOGY (STANDALONE) CW120442 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: NM Parent award description: IGF::CL::IGF COMPETITION FOR MANAGEMENT AND OPERATION OF LOS ALAMOS NATIONAL LABORATORY View parent award on USAspending | — | $1,000,000 | Apr 15, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | OPTION 16E: T-CELL PROTECTION AGAINST ZOONOTIC SARBECO & MERBECO COVS (GRIFONI) (MOD 21) GR-0010602-PO119478 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: TN Parent award description: AWARD OF THE BASE TO ST. JUDE FOR CEIRR CONTRACT 75N93021C00016. THIS CONTRACT WILL SUPPORT NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR). View parent award on USAspending | — | $366,000 | Jun 30, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | LJI-BARDA SUDAN-NHP STUDY 3 A11490 Parent award context Parent award agency: Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response Parent award NAICS: 541714 Parent award performance state: NY Parent award description: THE OVERALL OBJECTIVE OF THIS CONTRACT IS TO ADVANCE THE DEVELOPMENT OF MONOVALENT VACCINES FOR PREVENTION OF MARBURG VIRUS (MARV) AND SUDAN EBOLAVIRUS (SUDV) DISEASE. THESE VACCINES ARE BASED ON RECOMBINANT EXPRESSION OF FILOVIRUS GLYCOPROTEINS IN View parent award on USAspending | — | $324,941 | Nov 25, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | THROUGH THE EXECUTION OF THIS CONTRACT, WE WILL EXAMINE BASIC INDUCTION OF INNATE AND ADAPTIVE IMMUNITY FROM VACCINATION, INCLUDING STUDIES THAT ADDRESS NTM INTERFERENCE, RNA DELIVERY, PRIME-BOOST REGIMENS (INCLUDING BCG PRE-EXPOSURE), TRANSCRIPTOMIC HOST SIGNATURES, PROTEOMICS, SYSTEMS BIOLOGY AND DURABLE IMMUNE MEMORY FOR THE FURTHER ADVANCEMENT OF THE EFFORT TO DESIGN AND EVALUATE AN EFFICACIOUS VACCINE AGAINST MYCOBACTERIUM TUBERCULOSIS (M.TB).
BASE ACTIVITIES: DEVELOP IMMUNE RESPONSE ASSAYS AND HARMONIZE PROTOCOLS AND ASSAYS
TASK B.2: IMMUNOLOGICAL ASSAY DEVELOPMENT, HARMONIZATION OF PROTOCOLS AND IN VIVO STUDIES
TO ENSURE THAT BIOLOGICAL RESULTS GENERATED IN THE VARIOUS CONSORTIUM LABS ARE COMPARABLE, WE WILL STANDARDIZE THE PRIMARY ASSAYS USED IN IMMUNOGENICITY ASSESSMENTS FOR EACH SPECIES. IN LINE WITH THE PROJECT GOALS TO DEVELOP A CROSS-SPECIES INTERROGATION PLATFORM, WE WILL HARMONIZE KEY ASSAYS ACROSS MULTIPLE SPECIES. SCRI WILL APPOINT AN OVERALL TASK LEADER TO COORDINATE AND OVERSEE THE WORK. ALL ASSAY STANDARD OPERATING PROCEDURES (SOP) WILL BE SHARED WITH A PRECLINICAL LABORATORY LEAD, DESIGNATED FOR EACH ASSAY, WHO WILL BE RESPONSIBLE FOR HARMONIZING. FINAL SOPS WILL BE SHARED AND LEAD ASSAY LABS WILL CONDUCT SIDE-BY-SIDE TRAINING SESSIONS, AS WELL AS, MAINTAIN AND DISTRIBUTE COMMON REFERENCE STANDARDS AND REAGENTS, SUCH AS IDENTICAL STIMULATION ANTIGENS (BCG, PPD, SEB, 15-MER PEPTIDES, M.TB LYSATE, NTM LYSATE AND UNSTIMULATED) AND BCG VACCINATION STRAIN (BCG AJ/BCG SSI). THIS BASE-PERIOD HARMONIZATION WILL INCLUDE OPTIMIZED MULTICOLOR IMMUNOFLUORESCENCE PANEL (OMIP) DEVELOPMENT.
FURTHERMORE, LJI WILL ASSIST IN THE ANALYSIS OF REACTIVITY OF PEPTIDES IN HUMAN AND ANIMAL MODELS IN ANTIGENICITY ASSAYS PRIOR TO IMPLEMENTATION IN OPTIONS 1-4.
A POOL OF 15-MER T CELL EPITOPES WHICH ARE FOUND IN DIVERSE NTMS BUT ABSENT FROM MTB (PMID: 25548174) WILL BE SUPPLIED BY LJI IN THE BASE PERIOD TO COLLABORATOR LABS THAT REQUIRE THEM FOR IMMUNE PHENOTYPING ASSAYS. TAKING ADVANTAGE OF THE RECENTLY DEVELOPED APPROACH OF COMBINING A LARGE NUMBER OF EPITOPES IN ONE SINGLE POOL AS A "MEGAPOOL" (PMID: 27409590) WE COMBINE ALL EPITOPES IDENTIFIED IN THE PNAS STUDY TOGETHER WITH PEPTIDES IDENTIFIED BY OTHER MEMBERS OF OUR GROUP (PMID: 22046285). IN SUMMARY, LJI WILL PROVIDE:
A. MEGAPOOL OF 15-MER T CELL EPITOPES WHICH ARE FOUND IN DIVERSE NTMS BUT ABSENT FROM M.TB
B. MEGAPOOL OF M. TUBERCULOSIS-DERIVED EPITOPES (MTB300).
C. MEGAPOOL OF M. TUBERCULOSIS-DERIVED EPITOPES FROM WHICH ID93-DERIVED EPITOPES WERE OMITTED (MTB300-ID93 ).
A SUMMARY REPORT OF ALL ACTIVITIES AND STANDARDIZED PROTOCOLS FROM THE BASE PERIOD WILL BE DRAFTED AND SUBMITTED TO NIAID FOR REVIEW AND APPROVAL. LJI WILL PROVIDE ALL THE NECESSARY DATA AND INPUT REQUIRED FOR THE COMPLETION AND ACCEPTANCE OF THE ANIMAL STUDY REPORT. SHIPMENT PLANNING AND DOCUMENTATION WILL BE PROVIDED FOR OVERLAPPING 15-MER PEPTIDES TO BE USED IN PRECLINICAL AND HUMAN IMMUNOLOGIC STUDIES.
CONTRACT PERIOD-SPECIFIC TASK TABLE OF DELIVERABLES:
DELIVERABLE TASK DESCRIPTION DUE DATE
DUE THIS CONTRACT PERIOD B2 DRAFT AND FINAL STUDY PROTOCOL AND METHOD SOPS 08 JULY 2022
B2 DRAFT MANUSCRIPT FOR NIAID REVIEW 01 AUG 2022
REPORTING REQUIREMENTS:
ALL REPORTS MUST BE SUBMITTED TO THE PRIME CONTRACTOR€„¢S PRINCIPAL INVESTIGATOR IDENTIFIED IN ATTACHMENT 3A.
DESCRIPTION DELIVERY SCHEDULE
MONTHLY PROGRESS REPORTS 8TH OF THE MONTH FOLLOWING THE REPORTING PERIOD. THE FIRST MONTHLY PROGRESS REPORT IS DUE ON DECEMBER 8, 2021.
REPORTING TEMPLATE USED IS AT THE DISCRETION OF THE SUBCONTRACTOR AS LONG AS IT CONTAINS THE FOLLOWING INFORMATION WITH HEADERS: CURRENT TASK; PROGRESS TOWARDS OBJECTIVES; CHALLENGES; NEXT STEPS/RECOMMENDATIONS.
ANNUAL PROGRESS REPORT 8TH OF THE MONTH FOLLOWING EACH ANNIVERSARY DATE OF THE SUBCONTRACT. THE FIRST ANNUAL REPORT IS DUE ON AUGUST 8TH, 2022.
ANNUAL TECHNICAL PROGRESS REPORT FOR CLINICAL RESEARCH STUDY POPULATIONS 8TH OF THE MONTH FOLLOWING EACH ANNIVER 12957SUB Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: WA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $30,050 | Dec 31, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | LJI-BARDA SUDAN-NHP STUDY 1 A10322 Parent award context Parent award agency: Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response Parent award NAICS: 541714 Parent award performance state: NY Parent award description: THE OVERALL OBJECTIVE OF THIS CONTRACT IS TO ADVANCE THE DEVELOPMENT OF MONOVALENT VACCINES FOR PREVENTION OF MARBURG VIRUS (MARV) AND SUDAN EBOLAVIRUS (SUDV) DISEASE. THESE VACCINES ARE BASED ON RECOMBINANT EXPRESSION OF FILOVIRUS GLYCOPROTEINS IN View parent award on USAspending | — | $322,725 | Sep 9, 2022 | — – — |
| Subcontractor | Department of Defense | IN THIS APPLICATION, THE SAPHIRE LAB AT LA JOLLA INSTITUTE FOR IMMUNOLOGY WILL EXPRESS AND PURIFY RECOMBINANT
EBOLA GP AND SGP AND ANTIBODIES AGAINST IT FOR BINDING AND STRUCTURAL STUDIES IN THE SAPHIRE LAB AND FOR
FUNCTIONAL STUDIES IN THE ALTER LAB AT THE RAGON INSTITUTE. 240237 Parent award context Parent award agency: Department of Defense · Defense Threat Reduction Agency Parent award NAICS: 541715 Parent award performance state: MA Parent award description: BREAKING THE CODE OF HUMORAL CORRELATES OF PROTECTION AGAINST EBOLA View parent award on USAspending | — | $194,505 | Mar 17, 2022 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Health and Human ServicesGov-sourced
- Department of DefenseGov-sourced
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.