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PRESIDENT AND FELLOWS OF HARVARD COLLEGE
CAMBRIDGE, MA, 02138
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Other Than Small Business
Prime contracting experience
21 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services National Institutes of Health | IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) | — | $59,907,089 | Aug 25, 2026 | Sep 30, 2019 – Sep 29, 2027 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | EO 14398 BIOSTATISTICIAN, DATA SCIENTIST, DATABASE ANALYST, AND DATA ANALYST EXPERTISE | 36C24E24D0023USAspending | $1,123,416 | Aug 21, 2026 | Sep 17, 2026 – Sep 16, 2027 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | BIOSTATISTICIAN, DATA SCIENTIST, DATABASE ANALYST, AND DATA ANALYST EXPERTISE | 36C24E24D0023USAspending | $965,353 | Jul 22, 2026 | Sep 17, 2025 – Sep 16, 2026 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | PUBLIC HEALTH RECOMMENDATIONS DEVELOPMENT | — | $698,305 | Apr 16, 2026 | Sep 13, 2021 – Sep 25, 2024 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | EPIDEMIOLOGY BIOINFORMATICS SUPPORT SERVICES FOR MAVERIC | 36C24E24D0023USAspending | $900,820 | Apr 1, 2026 | Sep 17, 2024 – Sep 17, 2024 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | PARTICULATE MATTER EXPOSURE RESEARCH | — | $965,701 | Dec 17, 2025 | Jan 1, 2023 – Jun 30, 2026 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH SERVICES BIONFORMATICS | 36C24E18D0048USAspending | $862,993 | May 28, 2025 | Aug 27, 2023 – Aug 26, 2024 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH SERVICES BIONFORMATICS | 36C24E18D0048USAspending | $719,073 | May 1, 2025 | Aug 28, 2019 – Aug 27, 2019 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH SERVICES BIONFORMATICS | 36C24E18D0048USAspending | $397,585 | Feb 20, 2025 | Aug 31, 2018 – Aug 30, 2019 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | DATA ANALYSIS SERVCIES | — | $494,641 | Nov 14, 2024 | Sep 30, 2022 – Sep 29, 2023 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | CASUAL INFERENCE ANALYST SUPPORT SERVICES FOR VA FUNDED RESEARCH | — | $3,183,777 | Sep 6, 2024 | Sep 30, 2023 – Sep 29, 2025 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH SERVICES BIONFORMATICS | 36C24E18D0048USAspending | $957,779 | Feb 15, 2024 | Aug 28, 2022 – Aug 27, 2023 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | CAUSAL INFERENCE ANALYST SUPPORT SERVICES FOR VA FUNDED RESEARCH | — | $1,395,583 | Jan 11, 2024 | Sep 30, 2022 – Sep 29, 2023 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH SERVICES BIONFORMATICS | 36C24E18D0048USAspending | $1,097,161 | Jan 3, 2024 | Aug 28, 2020 – Aug 27, 2021 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | IGF::OT::IGF RESEARCH AND DEVELOPMENT SERVICES | — | $1,499,366 | Oct 30, 2023 | Sep 24, 2018 – Dec 31, 2022 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | CAUSAL INFERENCE SERVICE SUPPORT | — | $733,139 | Sep 20, 2023 | Sep 30, 2021 – Sep 29, 2022 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH SERVICES BIONFORMATICS | 36C24E18D0048USAspending | $973,491 | Sep 19, 2023 | Aug 28, 2021 – Aug 27, 2022 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | IGF::OT::IGF STUDY OF PRINTER-EMITTED ENGINEERED NANOPARTICPLES | — | $270,000 | Jul 29, 2023 | Aug 11, 2017 – Dec 31, 2020 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | IGF::OT::IGF RESEARCH AND DEVELOPMENT SERVICES | — | $1,480,908 | Jun 26, 2023 | Sep 26, 2016 – Sep 25, 2019 |
| Prime | Department of Veterans Affairs Department of Veterans Affairs | RESEARCH | — | $1,559,347 | Feb 28, 2023 | Mar 1, 2023 – Feb 29, 2024 |
| Prime | Department of Health and Human Services National Institutes of Health | IGF::OT::IGF PILOT RECRUITMENT AND FOLLOW-UP FOR THE INTERGENERATIONAL HEALTH STUDY OF THE LONG-TERM INTERGENERATIONAL HEALTH IMPACTS OF MATERNAL OBESITY AND GESTATIONAL DIABETES AND THEIR DETERMINANTS. | HHSN275201600003IUSAspending | $1,485,717 | Aug 23, 2022 | Mar 1, 2017 – Jun 30, 2019 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
8 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | THROUGH THE EXECUTION OF THIS CONTRACT, WE WILL EXAMINE BASIC INDUCTION OF INNATE AND ADAPTIVE IMMUNITY FROM VACCINATION, INCLUDING STUDIES THAT ADDRESS NTM INTERFERENCE, RNA DELIVERY, PRIME-BOOST REGIMENS (INCLUDING BCG PRE-EXPOSURE), TRANSCRIPTOMIC HOST SIGNATURES, SYSTEMS BIOLOGY AND DURABLE IMMUNE MEMORY FOR THE FURTHER ADVANCEMENT OF THE EFFORT TO DESIGN AND EVALUATE AN EFFICACIOUS VACCINE AGAINST MYCOBACTERIUM TUBERCULOSIS (M.TB).
THE WORK UNDER THIS CONTRACT MAY INCLUDE THE POSSIBLE DISTRIBUTION OF DE-IDENTIFIED HUMAN SUBJECT PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC), SERUM, AND OTHER CLINICAL SAMPLES TO SCRI AND THE PHOENIX PARTNERS. NON-HUMAN PRIMATE (NHP) SAMPLES AND/OR DOWNSTREAM DATA MAY BE SHARED WITH THE PARTNERS ON THIS CONTRACT.
OPTION 3 ACTIVITIES: EVALUATE OPTIMIZED M.TB VACCINE CANDIDATES FOR SAFETY, IMMUNOGENICITY AND EFFICACY IN THE NHP MODEL OF TB
SCRI HAS WORKED WITH DR. RYAN MCNAMARA, WHO HAS PREVIOUSLY BEEN EMPLOYED AT THE RAGON INSTITUTE, TO DEVELOP A WORKPLAN FOR THE SYSTEM SEROLOGY ENDPOINTS FOR BOTH CLINICAL AND PRECLINICAL EVALUATIONS. WE HAVE CONFIRMED THAT A LIST OF 207 M.TB ANTIGENS THAT WERE RECENTLY PUBLISHED ARE NOT PROPRIETARY TO RAGON AND ARE AN APPROPRIATE SET FOR OUR INVESTIGATIONS.
TASK 3.7 COMPARE IMMUNE PROFILES IN NHP, SMALL ANIMAL MODELS AND HUMANS TO IDENTIFY CORRELATES OF PROTECTION.
SUBTASK 3.7.1 EVALUATE HUMORAL IMMUNITY AS A VACCINE-INDUCED CORRELATE OF PROTECTION USING SYSTEMS SEROLOGY IN THE NHP MODEL.
SEVERAL EFFECTOR FUNCTIONS BASED ON THE FC PORTION OF THE ANTIBODY CAN CONTRIBUTE TO THE CLEARANCE OF ORGANISMS, INCLUDING COMPLEMENT ACTIVITY, ANTIBODY-DEPENDENT CELLULAR PHAGOCYTOSIS (ADCP), ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC), ANTIBODY-DEPENDENT CYTOKINE AND CHEMOKINE SECRETION. SYSTEMS SEROLOGY ANALYSIS WILL BE USED TO EVALUATE ANTIBODY EFFECTOR FUNCTIONS INCLUDING NK CELL ACTIVATION, ADCP, AND ADCC. THESE ASSAYS CAPTURE OVER 100 BIOPHYSICAL AND FUNCTIONAL CHARACTERISTICS OF POLYCLONAL ABS, INCLUDING CYTOLYTIC ACTIVITY, PHAGOCYTIC TARGET CLEARANCE, CYTOKINE SECRETION, AND IMMUNOMODULATOR RELEASE. THIS SUITE OF FUNCTIONAL ASSAYS WILL BE UTILIZED TO BROADLY DEFINE THE FC PROFILES OF ID93- AND BCG-SPECIFIC ABS. FOR ALL FUNCTIONAL ASSAYS, THE FUNCTIONAL ACTIVITY OF ABS WILL BE ASSESSED AGAINST ID93, PPD, INFLUENZA HEMAGGLUTININ (CONTROL), EBOLA VIRUS GLYCOPROTEIN (NEGATIVE CONTROL). ALL ANTIGENS WILL BE BIOTINYLATED AND ATTACHED TO STREPTAVIDIN-FLUORESCENT BEADS (THERMO FISHER). SIGMA INTRAVENOUS IG WILL BE USED AS A POSITIVE CONTROL. SAMPLES RECEIVED FROM COLLABORATORS ON THIS PROJECT (MOUSE, GUINEA PIG, NHP AND HUMAN) WILL BE USED TO CARRY OUT THE SYSTEMS SEROLOGY APPROACH DETAILED BELOW.
SYSTEMS SEROLOGY CAPTURES LARGE NUMBERS OF DISTINCT ANTIGEN-SPECIFIC SERUM-BASED ANTIBODY PROFILE FEATURES THAT COMPREHENSIVELY AND OBJECTIVELY PROBES THE ANTIGEN-SPECIFIC FC-ANTIBODY-OME AT UNPRECEDENTED DEPTH. DISPARATE 53 DATA POINTS WILL BE INTEGRATED AND A SPECTRUM OF COMPUTATIONAL METHODS FOR CONSTRUCTING MULTI-VARIATE MODELS AND THEN APPLIED TO ASCERTAIN PREDICTIVE RELATIONSHIPS BETWEEN COMBINATIONS OF SYSTEM VARIABLES (STRUCTURE:FUNCTION, TRANSFER, ETC.) TO DEFINE NOVEL AND OFTEN UNEXPECTED INSIGHTS INTO THE ANTIBODY CHARACTERISTICS THAT DRIVE UNIQUE AND DISTINCT BIOLOGICAL OUTCOMES. THESE ANALYTICAL METHODS INCLUDE NON-NEGATIVE MATRIX FACTORIZATION, SELF-ORGANIZING MAPS, MULTI-LINEAR REGRESSION, PARTIAL LEAST-SQUARES DISCRIMINATION, DECISION TREES, AND RANDOM FORESTS AMONG OTHERS, INCLUDING FEATURE REDUCTION WHEN NECESSARY FOR CONSTRAINING THE NUMBER OF REGULATORY VARIABLES TO HELP PREVENT MODEL OVER-FITTING. TWO SPECIFIC APPROACHES WILL BE UTILIZED TO DEFINE IMMUNE RESPONSE AND IMMUNE CORRELATES OF PROTECTION ASSOCIATED CHANGES USING BOTH “FLAT” AND “HIERARCHICAL” FRAMEWORKS. IN THE “FLAT” FRAMEWORK, A SINGLE-LEVEL MODEL WILL BE UTILIZED – EXPLOITED EACH DATA POINT AS AN INDEPENDENT VARIABLE. THIS AGNOSTIC APPROACH ENABLES THE UNBIASED IDENTIFICATION OF INDIVIDU SUB00002382 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: WA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $573,209 | Sep 10, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | THROUGH THE EXECUTION OF THIS CONTRACT, WE WILL EXAMINE BASIC INDUCTION OF INNATE AND ADAPTIVE IMMUNITY FROM VACCINATION, INCLUDING STUDIES THAT ADDRESS NTM INTERFERENCE, RNA DELIVERY, PRIME-BOOST REGIMENS (INCLUDING BCG PRE-EXPOSURE), TRANSCRIPTOMIC HOST SIGNATURES, SYSTEMS BIOLOGY AND DURABLE IMMUNE MEMORY FOR THE FURTHER ADVANCEMENT OF THE EFFORT TO DESIGN AND EVALUATE AN EFFICACIOUS VACCINE AGAINST MYCOBACTERIUM TUBERCULOSIS (M.TB).
THE WORK UNDER THIS CONTRACT MAY INCLUDE THE POSSIBLE DISTRIBUTION OF DE-IDENTIFIED HUMAN SUBJECT PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC), SERUM, AND OTHER CLINICAL SAMPLES TO SCRI AND THE PHOENIX PARTNERS. NON-HUMAN PRIMATE (NHP) SAMPLES AND/OR DOWNSTREAM DATA MAY BE SHARED WITH THE PARTNERS ON THIS CONTRACT.
OPTION 3 ACTIVITIES: EVALUATE OPTIMIZED M.TB VACCINE CANDIDATES FOR SAFETY, IMMUNOGENICITY AND EFFICACY IN THE NHP MODEL OF TB
SCRI HAS WORKED WITH DR. RYAN MCNAMARA, WHO HAS PREVIOUSLY BEEN EMPLOYED AT THE RAGON INSTITUTE, TO DEVELOP A WORKPLAN FOR THE SYSTEM SEROLOGY ENDPOINTS FOR BOTH CLINICAL AND PRECLINICAL EVALUATIONS. WE HAVE CONFIRMED THAT A LIST OF 207 M.TB ANTIGENS THAT WERE RECENTLY PUBLISHED ARE NOT PROPRIETARY TO RAGON AND ARE AN APPROPRIATE SET FOR OUR INVESTIGATIONS.
TASK 3.7 COMPARE IMMUNE PROFILES IN NHP, SMALL ANIMAL MODELS AND HUMANS TO IDENTIFY CORRELATES OF PROTECTION.
SUBTASK 3.7.1 EVALUATE HUMORAL IMMUNITY AS A VACCINE-INDUCED CORRELATE OF PROTECTION USING SYSTEMS SEROLOGY IN THE NHP MODEL.
SEVERAL EFFECTOR FUNCTIONS BASED ON THE FC PORTION OF THE ANTIBODY CAN CONTRIBUTE TO THE CLEARANCE OF ORGANISMS, INCLUDING COMPLEMENT ACTIVITY, ANTIBODY-DEPENDENT CELLULAR PHAGOCYTOSIS (ADCP), ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY (ADCC), ANTIBODY-DEPENDENT CYTOKINE AND CHEMOKINE SECRETION. SYSTEMS SEROLOGY ANALYSIS WILL BE USED TO EVALUATE ANTIBODY EFFECTOR FUNCTIONS INCLUDING NK CELL ACTIVATION, ADCP, AND ADCC. THESE ASSAYS CAPTURE OVER 100 BIOPHYSICAL AND FUNCTIONAL CHARACTERISTICS OF POLYCLONAL ABS, INCLUDING CYTOLYTIC ACTIVITY, PHAGOCYTIC TARGET CLEARANCE, CYTOKINE SECRETION, AND IMMUNOMODULATOR RELEASE. THIS SUITE OF FUNCTIONAL ASSAYS WILL BE UTILIZED TO BROADLY DEFINE THE FC PROFILES OF ID93- AND BCG-SPECIFIC ABS. FOR ALL FUNCTIONAL ASSAYS, THE FUNCTIONAL ACTIVITY OF ABS WILL BE ASSESSED AGAINST ID93, PPD, INFLUENZA HEMAGGLUTININ (CONTROL), EBOLA VIRUS GLYCOPROTEIN (NEGATIVE CONTROL). ALL ANTIGENS WILL BE BIOTINYLATED AND ATTACHED TO STREPTAVIDIN-FLUORESCENT BEADS (THERMO FISHER). SIGMA INTRAVENOUS IG WILL BE USED AS A POSITIVE CONTROL. SAMPLES RECEIVED FROM COLLABORATORS ON THIS PROJECT (MOUSE, GUINEA PIG, NHP AND HUMAN) WILL BE USED TO CARRY OUT THE SYSTEMS SEROLOGY APPROACH DETAILED BELOW.
SYSTEMS SEROLOGY CAPTURES LARGE NUMBERS OF DISTINCT ANTIGEN-SPECIFIC SERUM-BASED ANTIBODY PROFILE FEATURES THAT COMPREHENSIVELY AND OBJECTIVELY PROBES THE ANTIGEN-SPECIFIC FC-ANTIBODY-OME AT UNPRECEDENTED DEPTH. DISPARATE 53 DATA POINTS WILL BE INTEGRATED AND A SPECTRUM OF COMPUTATIONAL METHODS FOR CONSTRUCTING MULTI-VARIATE MODELS AND THEN APPLIED TO ASCERTAIN PREDICTIVE RELATIONSHIPS BETWEEN COMBINATIONS OF SYSTEM VARIABLES (STRUCTURE:FUNCTION, TRANSFER, ETC.) TO DEFINE NOVEL AND OFTEN UNEXPECTED INSIGHTS INTO THE ANTIBODY CHARACTERISTICS THAT DRIVE UNIQUE AND DISTINCT BIOLOGICAL OUTCOMES. THESE ANALYTICAL METHODS INCLUDE NON-NEGATIVE MATRIX FACTORIZATION, SELF-ORGANIZING MAPS, MULTI-LINEAR REGRESSION, PARTIAL LEAST-SQUARES DISCRIMINATION, DECISION TREES, AND RANDOM FORESTS AMONG OTHERS, INCLUDING FEATURE REDUCTION WHEN NECESSARY FOR CONSTRAINING THE NUMBER OF REGULATORY VARIABLES TO HELP PREVENT MODEL OVER-FITTING. TWO SPECIFIC APPROACHES WILL BE UTILIZED TO DEFINE IMMUNE RESPONSE AND IMMUNE CORRELATES OF PROTECTION ASSOCIATED CHANGES USING BOTH “FLAT” AND “HIERARCHICAL” FRAMEWORKS. IN THE “FLAT” FRAMEWORK, A SINGLE-LEVEL MODEL WILL BE UTILIZED – EXPLOITED EACH DATA POINT AS AN INDEPENDENT VARIABLE. THIS AGNOSTIC APPROACH ENABLES THE UNBIASED IDENTIFICATION OF INDIVIDU SUB00002406 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: WA Parent award description: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) View parent award on USAspending | — | $60,849 | May 14, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | SUBCONTRACT 1-312-0218720 MOD 1 1-312-0218720 MOD 1 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541690 Parent award performance state: PA Parent award description: COST EFFECTIVENESS ANALYSIS SERVICES FOR TBESC-III View parent award on USAspending | — | $83,447 | Sep 24, 2024 | — – — |
| Subcontractor | Department of Homeland Security | ADD-ON PROJECT 22-1155: TRANSFORMING THE EMI SCON-00000642 Parent award context Parent award agency: Department of Homeland Security · Federal Emergency Management Agency Parent award NAICS: 541720 Parent award performance state: MD Parent award description: EMI REVITALIZATION PROJECT View parent award on USAspending | 70RSAT22D00000001USAspending | $500,000 | Feb 16, 2024 | — – — |
| Subcontractor | Department of Homeland Security | ADD-ON PROJECT 22-1155: TRANSFORMING THE EMI SCON-00000570 Parent award context Parent award agency: Department of Homeland Security · Federal Emergency Management Agency Parent award NAICS: 541720 Parent award performance state: MD Parent award description: EMI REVITALIZATION PROJECT View parent award on USAspending | 70RSAT22D00000001USAspending | $73,214 | Jun 7, 2023 | — – — |
| Subcontractor | Department of Homeland Security | ADD-ON PROJECT 22-1155: TRANSFORMING THE EMI SCON-00000563 Parent award context Parent award agency: Department of Homeland Security · Federal Emergency Management Agency Parent award NAICS: 541720 Parent award performance state: MD Parent award description: EMI REVITALIZATION PROJECT View parent award on USAspending | 70RSAT22D00000001USAspending | $73,214 | Feb 27, 2023 | — – — |
| Subcontractor | Millennium Challenge Corporation | HUMAN RESOURCES DIVISION PROGRAM DEVELOPMENT, PLANNING, IMPLEMENTATION 112488-0 Parent award context Parent award agency: Millennium Challenge Corporation · Millennium Challenge Corporation Parent award NAICS: 611430 Parent award performance state: DC Parent award description: HR CELD CALL ORDER #1 View parent award on USAspending | 95332419A0018USAspending | $36,000 | Jan 5, 2023 | — – — |
| Subcontractor | Millennium Challenge Corporation | HUMAN RESOURCES DIVISION PROGRAM DEVELOPMENT, PLANNING, IMPLEMENTATION 109846-0 Parent award context Parent award agency: Millennium Challenge Corporation · Millennium Challenge Corporation Parent award NAICS: 611430 Parent award performance state: DC Parent award description: HR CELD CALL ORDER #1 View parent award on USAspending | 95332419A0018USAspending | $31,000 | Dec 17, 2021 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Veterans AffairsGov-sourced
- Department of Health and Human ServicesGov-sourced
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.