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UNIVERSITY OF TEXAS AT DALLAS
RICHARDSON, TX, 75080
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Other Than Small Business
Prime contracting experience
6 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | National Aeronautics and Space Administration National Aeronautics and Space Administration | THIS PROCUREMENT IS FOR THE THERMAL PLASMA SENSOR (TPS). | — | $2,885,949 | Sep 15, 2026 | Apr 23, 2026 – Feb 29, 2028 |
| Prime | Department of Defense Department of the Army | SERDP PROJECT ER23-4582 (FOLLOW-ON TO ER22-3119) HIGH-CAPACITY SUSTAINABLE SORBENTS FOR TREATMENT OF PFAS | — | $473,020 | Jun 24, 2026 | Nov 6, 2024 – Nov 5, 2027 |
| Prime | National Aeronautics and Space Administration National Aeronautics and Space Administration | PHASE A-B BRIDGE TPS INSTRUMENT FOR GDC SPACECRAFT | — | $4,501,037 | Sep 29, 2025 | Jul 1, 2023 – Sep 30, 2025 |
| Prime | Department of Defense Missile Defense Agency | UT DALLAS TWO-PHOTON ABSORPTION LASER SYSTEM ENHANCEMENTS | — | $990,000 | May 22, 2025 | Aug 26, 2024 – Aug 25, 2025 |
| Prime | National Aeronautics and Space Administration National Aeronautics and Space Administration | DEVELOPMENT AND SUPPORT OF A CUBESAT ION VELOCITY METER (CS-IVM) IN SUPPORT OF SCINTILLATION PREDICTION OBSERVATIONS RESEARCH TASK (SPORT). | — | $710,106 | Jul 31, 2024 | Nov 7, 2017 – Dec 31, 2024 |
| Prime | National Aeronautics and Space Administration National Aeronautics and Space Administration | GEOSPACE DYNAMICS CONSTELLATION MISSION - THERMAL PLASMA SENSOR, LIMITED PHASE A | — | $575,981 | May 6, 2024 | Oct 4, 2022 – Jun 30, 2023 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
28 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of the Interior | RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, LIFE SCIENCES (EXCEPT NANOTECHNOLOGY AND BIOTECHNOLOGY) (SEE FOOTNO 5300114565 CO 3 Parent award context Parent award agency: Department of the Interior · Departmental Offices Parent award NAICS: 541715 Parent award performance state: CA Parent award description: ULTRA-WIDE BANDGAP SEMICONDUCTORS (UWBGS) View parent award on USAspending | — | -$180,000 | Sep 23, 2026 | — – — |
| Subcontractor | Department of Defense | COLLEGES, UNIVERSITIES AND PROFESSIONAL SCHOOLS 5300084714 CO 6 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: CA Parent award description: TECHNOLOGIES FOR HEAT REMOVAL IN ELECTRONICS AT THE DEVICE SCALE (THREADS) View parent award on USAspending | — | $265,494 | Nov 10, 2025 | — – — |
| Subcontractor | Department of Defense | COLLEGES, UNIVERSITIES AND PROFESSIONAL SCHOOLS 5300084714 CO 5 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: CA Parent award description: TECHNOLOGIES FOR HEAT REMOVAL IN ELECTRONICS AT THE DEVICE SCALE (THREADS) View parent award on USAspending | — | $44,506 | Jul 3, 2025 | — – — |
| Subcontractor | Department of Defense | INSTRUMENT SUPPORT FOR COSMIC-2 SATELLITES SUBCON006305 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541330 Parent award performance state: CO Parent award description: THE CONSTELLATION OBSERVING SYSTEM FOR METEOROLOGY, IONOSPHERE, AND CLIMATE (COSMIC-2) SPACE SITUATION AWARENESS AND ENVIRONMENTAL MONITORING (SSAEM) PROGRAM PROVIDES SENSOR INTEGRATION AND SUPPORT SERVICES. View parent award on USAspending | — | $302,556 | Apr 22, 2025 | — – — |
| Subcontractor | Department of Defense | ASSURED MICROBIAL PRESERVATION IN HARSH OR REMOTE AREAS 0000900882 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541714 Parent award performance state: OH Parent award description: ASSURED MICROBIAL PRESERVATION IN HARSH OR REMOTE AREAS (AMPHORA)PHASE 1 View parent award on USAspending | — | $424,902 | Nov 21, 2024 | — – — |
| Subcontractor | Department of the Interior | RESEARCH AND DEVELOPMENT IN THE PHYSICAL, ENGINEERING, LIFE SCIENCES (EXCEPT NANOTECHNOLOGY AND BIOTECHNOLOGY) (SEE FOOTNO 5300114565 Parent award context Parent award agency: Department of the Interior · Departmental Offices Parent award NAICS: 541715 Parent award performance state: CA Parent award description: ULTRA-WIDE BANDGAP SEMICONDUCTORS (UWBGS) View parent award on USAspending | — | $539,997 | Oct 30, 2024 | — – — |
| Subcontractor | Department of Defense | UTD COST 1202431 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: NH Parent award description: NITRIDE ELECTRONICS WITH ENHANCED DEVICE LEVEL HEAT EXTRACTION (NEEDLE) View parent award on USAspending | — | $34,563 | Sep 19, 2024 | — – — |
| Subcontractor | Department of Defense | NRE - ALL. 4202970722 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541715 Parent award performance state: TX Parent award description: DARPA RESEARCH PROJECT View parent award on USAspending | — | $118,702 | Jul 23, 2024 | — – — |
| Subcontractor | Department of Defense | UTD COST 1202431 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: NH Parent award description: NITRIDE ELECTRONICS WITH ENHANCED DEVICE LEVEL HEAT EXTRACTION (NEEDLE) View parent award on USAspending | — | $39,974 | Jun 25, 2024 | — – — |
| Subcontractor | Department of Defense | COSMIC-2 POST LAUNCH SUPPORT SERVICES SUBCON001639 M10 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541330 Parent award performance state: CO Parent award description: SPACE SITUATIONAL AWARENESS ENVIRONMENTAL MONITORING View parent award on USAspending | — | $70,559 | May 16, 2024 | — – — |
| Subcontractor | Department of Defense | THE GOAL OF THIS PROJECT IS TO ADVANCE THE APPLICATION OF NOVEL HIGHCAPACITY
SORBENTS FOR SUSTAINABLE TREATMENT OF PFAS IN AFFF-IMPACTED WATERS. SPECIFIC
OBJECTIVES INCLUDE (1) ADAPT NOVEL SORBENTS TO ENABLE FLOW-THROUGH TREATMENT OF CONTAMINATED
WATER; (2) EVALUATE THEIR SORPTION CAPACITY AND KINETICS IN SINGLE COMPOUND AND COMPLEX AFFFCONTAINING
MATRICES; (3) DEVELOP SUSTAINABLE SORBENT REGENERATION APPROACHES; AND (4) EVALUATE
LONG-TERM SORPTION AND REGENERATION CAPACITY IN MULTI-CYCLE REGENERATION TESTS. 102687-3 · Prime awardUSAspending | — | $49,513 | Feb 20, 2024 | — – — |
| Subcontractor | Department of Defense | COLLEGES, UNIVERSITIES AND PROFESSIONAL SCHOOLS 5300084714 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: CA Parent award description: TECHNOLOGIES FOR HEAT REMOVAL IN ELECTRONICS AT THE DEVICE SCALE (THREADS) View parent award on USAspending | — | $46,000 | Jan 23, 2024 | — – — |
| Subcontractor | Department of Defense | TECHNICAL SERVICES 5300084714 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: CA Parent award description: TECHNOLOGIES FOR HEAT REMOVAL IN ELECTRONICS AT THE DEVICE SCALE (THREADS) View parent award on USAspending | — | $138,000 | Jan 22, 2024 | — – — |
| Subcontractor | Department of Defense | SECTION C - DESCRIPTIONS AND SPECIFICATIONS
STATEMENT OF WORK
SITE 1: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE, 660 S. EUCLID AVE., ST. LOUIS, MO 63110 COORDINATOR: CRAIG A. BUCHMAN, M.D., F.A.C.S.
SITE 2: UNIVERSITY OF AKRON SCHOOL OF SPEECH LANGUAGE PATHOLOGY AND AUDIOLOGY, 181 POLSKY, AKRON OH 44325 COORDINATOR: KRISTINE E SONSTROM MALOWSKI, AU.D., PH.D.
SITE 3: GATEWAY BIOTECHNOLOGY INC., 4041 FOREST PARK AVENUE, ST. LOUIS, MO 63108 COORDINATOR: JIANXIN BAO, PH.D.
SITE 4: THE UNIVERSITY OF TEXAS AT DALLAS, CALLIER CENTER FOR COMMUNICATION DISORDERS, 800 W. CAMPBELL RD. AD15, RICHARDSON, TEXAS, 75080
COORDINATOR: COLLEEN G. LE PRELL, PH.D.
ABBREVIATIONS: GWI: GATEWAY BIOTECHNOLOGY, INC.; UA: UNIVERSITY OF AKRON; UTD: UNIVERSITY OF TEXAS AT DALLAS; WUSM: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE.
STUDY 1: WE WILL TEST WHETHER THE DRUG ZONISAMIDE (ZNS) CAN PREVENT NOISE-INDUCED HEARING LOSS (NIHL) DUE TO DRILLING NOISE DURING SKULL SURGERY. WE WILL DO SO BY ANSWERING THREE CRITICAL QUESTIONS REGARDING POSSIBLE ZNS PROTECTION AGAINST NIHL: (1) WHETHER ZNS CAN PREVENT TEMPORARY THRESHOLD SHIFT (TTS); (2) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY, OR HIDDEN HEARING LOSS; AND (3) WHETHER ZNS CAN PREVENT PERMANENT THRESHOLD SHIFT (PTS).
STUDY 2: WE WILL TEST WHETHER ZNS CAN PREVENT NIHL IN POLICE OFFICERS, THUS DEMONSTRATING THAT ZNS PREVENTS NIHL UNDER CONDITIONS SIMILAR TO MILITARY ENVIRONMENTS. WE WILL DETERMINE: (1) WHETHER ZNS CAN PREVENT TTS 5 MINUTES AFTER THE SHOOTING SESSION; (2) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY AND PTS AFTER EVERY SHOOTING SESSION; AND (3) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY OR PTS EVERY YEAR FOR A DURATION OF TWO YEARS.
STUDY 3: WE WILL DETERMINE IF THERE IS A PHARMACOGENETIC (PGX) LINK BETWEEN NIHL AND ZNS TREATMENT. WE WILL DO SO BY IDENTIFYING CERTAIN GENETIC VARIANTS ASSOCIATED WITH ZNS PROTECTION AGAINST TTS AND PTS. IF SPECIFIC GENETIC VARIANTS ARE FOUND TO BE SIGNIFICANTLY ASSOCIATED WITH LOWER TTS AND PTS, THIS INFORMATION CAN BE USED TO DEVELOP A PERSONALIZED MEDICATION TO PREVENT NIHL.
TASKS TIMELINE SITES
STUDY 1: DETERMINE IF ZNS CAN PREVENT NOISE-INDUCED HEARING LOSS (NIHL) DUE TO SURGICAL DRILLING NOISE. WUSM, GWI, UTD
TAKE PART IN KICK-OFF MEETING AT FORT DETRICK. 01/2019 WUSM, GWI, UA, UTD
FINALIZE REGULATORY DOCUMENTS AND IRB PROTOCOL, AND OBTAIN APPROVAL BY THE U.S. ARMY HUMAN RESEARCH PROTECTIONS OFFICE (HRPO). 01/2019-05/2019 WUSM, UTD
REQUEST CONSULTATION WITH THE FDA; IND APPLICATION PREPARATION AND SUBMISSION TO THE FDA 01/2019-05/2019 WUSM
RECRUIT AND TEST 30 SUBJECTS (25% OF PLANNED ENROLLMENT) 06/2019-03/2020 WUSM
FOR QUALITY ASSURANCE, REVIEW ALL DATA WITH STUDY TEAM AS DATA ARE RECEIVED TO DETERMINE IF DATA ARE MISSING. 06/2019-03/2020 GWI, UTD
RECRUIT AND TEST 60 SUBJECTS (75% OF PLANNED ENROLLMENT). 04/2020-04/2021 WUSM
FOR QUALITY ASSURANCE, REVIEW ALL TESTING PROTOCOLS FOR INVESTIGATORS, AND DETERMINE THE PERCENTAGE OF MISSING DATA. 04/2020-04/2021 GWI
ENLIST INDEPENDENT STATISTICIANS TO PERFORM AN INTERIM MASKED ANALYSIS. 04/2021-05/2021 GWI, UTD
RECRUIT AND TEST 30 SUBJECTS (100% OF PLANNED ENROLLMENT). 05/2021-11/2021 WUSM
FOR QUALITY ASSURANCE, ENSURE ALL INVESTIGATORS PERFORM SECOND REVIEW OF ALL TESTING PROTOCOLS. 05/2021-11/2021 GWI
COMPLETE PRIMARY AND SECONDARY ENDPOINT DATA ANALYSES AND SUBMISSION OF THE FINAL REPORT FOR THE BASE TASK PERIOD. 11/2021-01/2022 WUSM, GWI, UTD
MEETINGS WITH FDA AND COMPLETE ADDITIONAL STUDIES NECESSARY FOR THE PHASE 3 STUDIES. 01/2022-03/2023 WUSM
PREPARE AND SUBMIT THE FINAL REPORT. 04/2023-012/2023 WUSM, GWI, UTD
OBTAIN FDA APPROVAL FOR THE PHASE 3 STUDY. 01/2023-12/2023 WUSM
STUDY 2: DETERMINE WHETHER ZNS CAN PREVENT NIHL IN POLICE OFFICERS. UA, GWI, UTD
PREPARE AN IND SUBMISSION WITH PHARM-OLAM. 01/2019-05/2019 WUSM,
PHARM-OLAM, UA, UTD
FINALIZE REGULATORY DOCUMENTS AND IRB PROTOCOL, AND OBTAIN APPROVAL BY THE U.S. ARMY HRPO. 01/2019-05/2019 UA, UTD
RECRUIT AND TEST 60 SUBJECTS (50% OF WU-20-126-MOD-5 Parent award context Parent award agency: Department of Defense · Defense Health Agency Parent award NAICS: 541715 Parent award performance state: MO Parent award description: REQUIREMENT: PHARMACEUTICAL INTERVENTIONS FOR NOISE INDUCED HEARING LOSS ACUTE EXPOSURE TREATMENT (PINIHL AET) ACTION: AWARD. View parent award on USAspending | — | $0 | Oct 31, 2023 | — – — |
| Subcontractor | Department of Defense | NRE - ALL. 4202853731 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541715 Parent award performance state: TX Parent award description: HIGH ENTHALPY APERTURE TECHNOLOGY (HEAT) View parent award on USAspending | — | $70,000 | Oct 17, 2023 | — – — |
| Subcontractor | Department of Defense | SERVICES TO SUPPORT THE COSMIC-2 PROGRAM. SUBCON001639 M09 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541330 Parent award performance state: CO Parent award description: SPACE SITUATIONAL AWARENESS ENVIRONMENTAL MONITORING View parent award on USAspending | — | $150,000 | Oct 11, 2023 | — – — |
| Subcontractor | Department of Defense | SERVICES TO SUPPORT THE COSMIC-2 PROGRAM SUBCON001639 M08 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541330 Parent award performance state: CO Parent award description: SPACE SITUATIONAL AWARENESS ENVIRONMENTAL MONITORING View parent award on USAspending | — | $22,000 | Aug 17, 2023 | — – — |
| Subcontractor | Department of Defense | SERVICES TO SUPPORT THE COSMIC-2 PROGRAM. SUBCON001639 M07 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541330 Parent award performance state: CO Parent award description: SPACE SITUATIONAL AWARENESS ENVIRONMENTAL MONITORING View parent award on USAspending | — | $54,694 | Jun 27, 2023 | — – — |
| Subcontractor | Department of Defense | SECTION C - DESCRIPTIONS AND SPECIFICATIONS
STATEMENT OF WORK
SITE 1: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE, 660 S. EUCLID AVE., ST. LOUIS, MO 63110 COORDINATOR: CRAIG A. BUCHMAN, M.D., F.A.C.S.
SITE 2: UNIVERSITY OF AKRON SCHOOL OF SPEECH LANGUAGE PATHOLOGY AND AUDIOLOGY, 181 POLSKY, AKRON OH 44325 COORDINATOR: KRISTINE E SONSTROM MALOWSKI, AU.D., PH.D.
SITE 3: GATEWAY BIOTECHNOLOGY INC., 4041 FOREST PARK AVENUE, ST. LOUIS, MO 63108 COORDINATOR: JIANXIN BAO, PH.D.
SITE 4: THE UNIVERSITY OF TEXAS AT DALLAS, CALLIER CENTER FOR COMMUNICATION DISORDERS, 800 W. CAMPBELL RD. AD15, RICHARDSON, TEXAS, 75080
COORDINATOR: COLLEEN G. LE PRELL, PH.D.
ABBREVIATIONS: GWI: GATEWAY BIOTECHNOLOGY, INC.; UA: UNIVERSITY OF AKRON; UTD: UNIVERSITY OF TEXAS AT DALLAS; WUSM: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE.
STUDY 1: WE WILL TEST WHETHER THE DRUG ZONISAMIDE (ZNS) CAN PREVENT NOISE-INDUCED HEARING LOSS (NIHL) DUE TO DRILLING NOISE DURING SKULL SURGERY. WE WILL DO SO BY ANSWERING THREE CRITICAL QUESTIONS REGARDING POSSIBLE ZNS PROTECTION AGAINST NIHL: (1) WHETHER ZNS CAN PREVENT TEMPORARY THRESHOLD SHIFT (TTS); (2) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY, OR HIDDEN HEARING LOSS; AND (3) WHETHER ZNS CAN PREVENT PERMANENT THRESHOLD SHIFT (PTS).
STUDY 2: WE WILL TEST WHETHER ZNS CAN PREVENT NIHL IN POLICE OFFICERS, THUS DEMONSTRATING THAT ZNS PREVENTS NIHL UNDER CONDITIONS SIMILAR TO MILITARY ENVIRONMENTS. WE WILL DETERMINE: (1) WHETHER ZNS CAN PREVENT TTS 5 MINUTES AFTER THE SHOOTING SESSION; (2) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY AND PTS AFTER EVERY SHOOTING SESSION; AND (3) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY OR PTS EVERY YEAR FOR A DURATION OF TWO YEARS.
STUDY 3: WE WILL DETERMINE IF THERE IS A PHARMACOGENETIC (PGX) LINK BETWEEN NIHL AND ZNS TREATMENT. WE WILL DO SO BY IDENTIFYING CERTAIN GENETIC VARIANTS ASSOCIATED WITH ZNS PROTECTION AGAINST TTS AND PTS. IF SPECIFIC GENETIC VARIANTS ARE FOUND TO BE SIGNIFICANTLY ASSOCIATED WITH LOWER TTS AND PTS, THIS INFORMATION CAN BE USED TO DEVELOP A PERSONALIZED MEDICATION TO PREVENT NIHL.
TASKS TIMELINE SITES
STUDY 1: DETERMINE IF ZNS CAN PREVENT NOISE-INDUCED HEARING LOSS (NIHL) DUE TO SURGICAL DRILLING NOISE. WUSM, GWI, UTD
TAKE PART IN KICK-OFF MEETING AT FORT DETRICK. 01/2019 WUSM, GWI, UA, UTD
FINALIZE REGULATORY DOCUMENTS AND IRB PROTOCOL, AND OBTAIN APPROVAL BY THE U.S. ARMY HUMAN RESEARCH PROTECTIONS OFFICE (HRPO). 01/2019-05/2019 WUSM, UTD
REQUEST CONSULTATION WITH THE FDA; IND APPLICATION PREPARATION AND SUBMISSION TO THE FDA 01/2019-05/2019 WUSM
RECRUIT AND TEST 30 SUBJECTS (25% OF PLANNED ENROLLMENT) 06/2019-03/2020 WUSM
FOR QUALITY ASSURANCE, REVIEW ALL DATA WITH STUDY TEAM AS DATA ARE RECEIVED TO DETERMINE IF DATA ARE MISSING. 06/2019-03/2020 GWI, UTD
RECRUIT AND TEST 60 SUBJECTS (75% OF PLANNED ENROLLMENT). 04/2020-04/2021 WUSM
FOR QUALITY ASSURANCE, REVIEW ALL TESTING PROTOCOLS FOR INVESTIGATORS, AND DETERMINE THE PERCENTAGE OF MISSING DATA. 04/2020-04/2021 GWI
ENLIST INDEPENDENT STATISTICIANS TO PERFORM AN INTERIM MASKED ANALYSIS. 04/2021-05/2021 GWI, UTD
RECRUIT AND TEST 30 SUBJECTS (100% OF PLANNED ENROLLMENT). 05/2021-11/2021 WUSM
FOR QUALITY ASSURANCE, ENSURE ALL INVESTIGATORS PERFORM SECOND REVIEW OF ALL TESTING PROTOCOLS. 05/2021-11/2021 GWI
COMPLETE PRIMARY AND SECONDARY ENDPOINT DATA ANALYSES AND SUBMISSION OF THE FINAL REPORT FOR THE BASE TASK PERIOD. 11/2021-01/2022 WUSM, GWI, UTD
MEETINGS WITH FDA AND COMPLETE ADDITIONAL STUDIES NECESSARY FOR THE PHASE 3 STUDIES. 01/2022-03/2023 WUSM
PREPARE AND SUBMIT THE FINAL REPORT. 04/2023-012/2023 WUSM, GWI, UTD
OBTAIN FDA APPROVAL FOR THE PHASE 3 STUDY. 01/2023-12/2023 WUSM
STUDY 2: DETERMINE WHETHER ZNS CAN PREVENT NIHL IN POLICE OFFICERS. UA, GWI, UTD
PREPARE AN IND SUBMISSION WITH PHARM-OLAM. 01/2019-05/2019 WUSM,
PHARM-OLAM, UA, UTD
FINALIZE REGULATORY DOCUMENTS AND IRB PROTOCOL, AND OBTAIN APPROVAL BY THE U.S. ARMY HRPO. 01/2019-05/2019 UA, UTD
RECRUIT AND TEST 60 SUBJECTS (50% OF WU-20-126-MOD-4 Parent award context Parent award agency: Department of Defense · Defense Health Agency Parent award NAICS: 541715 Parent award performance state: MO Parent award description: REQUIREMENT: PHARMACEUTICAL INTERVENTIONS FOR NOISE INDUCED HEARING LOSS ACUTE EXPOSURE TREATMENT (PINIHL AET) ACTION: AWARD. View parent award on USAspending | — | $41,870 | Mar 15, 2023 | — – — |
| Subcontractor | Department of Defense | SERVICES TO SUPPORT THE COSMIC-2 PROGRAM SUBCON001639 M06 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541330 Parent award performance state: CO Parent award description: SPACE SITUATIONAL AWARENESS ENVIRONMENTAL MONITORING View parent award on USAspending | — | $109,564 | Jan 16, 2023 | — – — |
| Subcontractor | Department of Defense | SECTION C - DESCRIPTIONS AND SPECIFICATIONS
STATEMENT OF WORK
SITE 1: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE, 660 S. EUCLID AVE., ST. LOUIS, MO 63110 COORDINATOR: CRAIG A. BUCHMAN, M.D., F.A.C.S.
SITE 2: UNIVERSITY OF AKRON SCHOOL OF SPEECH LANGUAGE PATHOLOGY AND AUDIOLOGY, 181 POLSKY, AKRON OH 44325 COORDINATOR: KRISTINE E SONSTROM MALOWSKI, AU.D., PH.D.
SITE 3: GATEWAY BIOTECHNOLOGY INC., 4041 FOREST PARK AVENUE, ST. LOUIS, MO 63108 COORDINATOR: JIANXIN BAO, PH.D.
SITE 4: THE UNIVERSITY OF TEXAS AT DALLAS, CALLIER CENTER FOR COMMUNICATION DISORDERS, 800 W. CAMPBELL RD. AD15, RICHARDSON, TEXAS, 75080
COORDINATOR: COLLEEN G. LE PRELL, PH.D.
ABBREVIATIONS: GWI: GATEWAY BIOTECHNOLOGY, INC.; UA: UNIVERSITY OF AKRON; UTD: UNIVERSITY OF TEXAS AT DALLAS; WUSM: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE.
STUDY 1: WE WILL TEST WHETHER THE DRUG ZONISAMIDE (ZNS) CAN PREVENT NOISE-INDUCED HEARING LOSS (NIHL) DUE TO DRILLING NOISE DURING SKULL SURGERY. WE WILL DO SO BY ANSWERING THREE CRITICAL QUESTIONS REGARDING POSSIBLE ZNS PROTECTION AGAINST NIHL: (1) WHETHER ZNS CAN PREVENT TEMPORARY THRESHOLD SHIFT (TTS); (2) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY, OR HIDDEN HEARING LOSS; AND (3) WHETHER ZNS CAN PREVENT PERMANENT THRESHOLD SHIFT (PTS).
STUDY 2: WE WILL TEST WHETHER ZNS CAN PREVENT NIHL IN POLICE OFFICERS, THUS DEMONSTRATING THAT ZNS PREVENTS NIHL UNDER CONDITIONS SIMILAR TO MILITARY ENVIRONMENTS. WE WILL DETERMINE: (1) WHETHER ZNS CAN PREVENT TTS 5 MINUTES AFTER THE SHOOTING SESSION; (2) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY AND PTS AFTER EVERY SHOOTING SESSION; AND (3) WHETHER ZNS CAN PREVENT COCHLEAR SYNAPTOPATHY OR PTS EVERY YEAR FOR A DURATION OF TWO YEARS.
STUDY 3: WE WILL DETERMINE IF THERE IS A PHARMACOGENETIC (PGX) LINK BETWEEN NIHL AND ZNS TREATMENT. WE WILL DO SO BY IDENTIFYING CERTAIN GENETIC VARIANTS ASSOCIATED WITH ZNS PROTECTION AGAINST TTS AND PTS. IF SPECIFIC GENETIC VARIANTS ARE FOUND TO BE SIGNIFICANTLY ASSOCIATED WITH LOWER TTS AND PTS, THIS INFORMATION CAN BE USED TO DEVELOP A PERSONALIZED MEDICATION TO PREVENT NIHL.
TASKS TIMELINE SITES
STUDY 1: DETERMINE IF ZNS CAN PREVENT NOISE-INDUCED HEARING LOSS (NIHL) DUE TO SURGICAL DRILLING NOISE. WUSM, GWI, UTD
TAKE PART IN KICK-OFF MEETING AT FORT DETRICK. 01/2019 WUSM, GWI, UA, UTD
FINALIZE REGULATORY DOCUMENTS AND IRB PROTOCOL, AND OBTAIN APPROVAL BY THE U.S. ARMY HUMAN RESEARCH PROTECTIONS OFFICE (HRPO). 01/2019-05/2019 WUSM, UTD
REQUEST CONSULTATION WITH THE FDA; IND APPLICATION PREPARATION AND SUBMISSION TO THE FDA 01/2019-05/2019 WUSM
RECRUIT AND TEST 30 SUBJECTS (25% OF PLANNED ENROLLMENT) 06/2019-03/2020 WUSM
FOR QUALITY ASSURANCE, REVIEW ALL DATA WITH STUDY TEAM AS DATA ARE RECEIVED TO DETERMINE IF DATA ARE MISSING. 06/2019-03/2020 GWI, UTD
RECRUIT AND TEST 60 SUBJECTS (75% OF PLANNED ENROLLMENT). 04/2020-04/2021 WUSM
FOR QUALITY ASSURANCE, REVIEW ALL TESTING PROTOCOLS FOR INVESTIGATORS, AND DETERMINE THE PERCENTAGE OF MISSING DATA. 04/2020-04/2021 GWI
ENLIST INDEPENDENT STATISTICIANS TO PERFORM AN INTERIM MASKED ANALYSIS. 04/2021-05/2021 GWI, UTD
RECRUIT AND TEST 30 SUBJECTS (100% OF PLANNED ENROLLMENT). 05/2021-11/2021 WUSM
FOR QUALITY ASSURANCE, ENSURE ALL INVESTIGATORS PERFORM SECOND REVIEW OF ALL TESTING PROTOCOLS. 05/2021-11/2021 GWI
COMPLETE PRIMARY AND SECONDARY ENDPOINT DATA ANALYSES AND SUBMISSION OF THE FINAL REPORT FOR THE BASE TASK PERIOD. 11/2021-01/2022 WUSM, GWI, UTD
MEETINGS WITH FDA AND COMPLETE ADDITIONAL STUDIES NECESSARY FOR THE PHASE 3 STUDIES. 01/2022-03/2023 WUSM
PREPARE AND SUBMIT THE FINAL REPORT. 04/2023-012/2023 WUSM, GWI, UTD
OBTAIN FDA APPROVAL FOR THE PHASE 3 STUDY. 01/2023-12/2023 WUSM
STUDY 2: DETERMINE WHETHER ZNS CAN PREVENT NIHL IN POLICE OFFICERS. UA, GWI, UTD
PREPARE AN IND SUBMISSION WITH PHARM-OLAM. 01/2019-05/2019 WUSM,
PHARM-OLAM, UA, UTD
FINALIZE REGULATORY DOCUMENTS AND IRB PROTOCOL, AND OBTAIN APPROVAL BY THE U.S. ARMY HRPO. 01/2019-05/2019 UA, UTD
RECRUIT AND TEST 60 SUBJECTS (50% OF WU-20-126-MOD-3 Parent award context Parent award agency: Department of Defense · Defense Health Agency Parent award NAICS: 541715 Parent award performance state: MO Parent award description: REQUIREMENT: PHARMACEUTICAL INTERVENTIONS FOR NOISE INDUCED HEARING LOSS ACUTE EXPOSURE TREATMENT (PINIHL AET) ACTION: AWARD. View parent award on USAspending | — | $34,133 | Feb 8, 2022 | — – — |
| Subcontractor | Department of Energy | MACHINE SERVICES N000425714 Parent award context Parent award agency: Department of Energy · Department of Energy Parent award NAICS: 561210 Parent award performance state: MO Parent award description: IGF::CL,CT::IGF MANAGEMENT AND OPERATION OF THE NATIONAL SECURITY CAMPUS -- CONTRACT NO. DE-NA0002839 View parent award on USAspending | — | $150,000 | Jan 19, 2022 | — – — |
| Subcontractor | Department of Defense | THIS STATEMENT OF WORK (SOW) SPECIFIES THE RESEARCH AND DEVELOPMENT TO BE PERFORMED
BY THE SUBCONTRACTOR TO SUPPORT UNIVERSITY OF ILLINOIS AT CHICAGO IN DESIGNING ALGORITHMS
AND DEVELOPING SOFTWARE, IN SUPPORT OF DARPA-HR001118S0040, COMPUTERS AND HUMANS
EXPLORING SOFTWARE SECURITY (CHESS). THE CHESS PROGRAM SEEKS INNOVATIVE SOLUTIONS
IN THE AREA OF COMPUTER-HUMAN SYSTEMS TO RAPIDLY DISCOVER ALL CLASSES OF VULNERABILITY IN
COMPLEX SOFTWARE. 17283 01-10 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: IL Parent award description: GAMEPLAY: GRAPH ANALYSIS FOR MECHANIZED EXPLOIT-GENERATION AND VULNERABILITY PATCHING LEVERAGING HUM View parent award on USAspending | — | $247,957 | Dec 16, 2021 | — – — |
| Subcontractor | Department of Defense | NRE - OTHER PHASE 1: DR. CHO ICME MODELING 4202505192 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541715 Parent award performance state: TX Parent award description: HIGH ENTHALPY APERTURE TECHNOLOGY (HEAT) View parent award on USAspending | — | $344,785 | Oct 8, 2021 | — – — |
| Subcontractor | Department of Defense | NRE - OTHER PHASE 1: DR RAY BAUGHMAN, NANOTECH INSTI 4202505177 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541715 Parent award performance state: TX Parent award description: HIGH ENTHALPY APERTURE TECHNOLOGY (HEAT) View parent award on USAspending | — | $120,000 | Oct 8, 2021 | — – — |
| Subcontractor | Department of Defense | NRE - ALL. 4202505177 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541715 Parent award performance state: TX Parent award description: HIGH ENTHALPY APERTURE TECHNOLOGY (HEAT) View parent award on USAspending | — | $118,702 | Oct 8, 2021 | — – — |
| Subcontractor | Department of Defense | NRE - ALL. 4202505192 Parent award context Parent award agency: Department of Defense · Defense Advanced Research Projects Agency Parent award NAICS: 541715 Parent award performance state: TX Parent award description: HIGH ENTHALPY APERTURE TECHNOLOGY (HEAT) View parent award on USAspending | — | $279,852 | Oct 8, 2021 | — – — |
| Subcontractor | Department of Defense | PRISM PROVIDES A PLATFORM FOR TRANSFORMING SOFTWARE, IN THE FORM OF SOURCE CODE AND/OR NON-OBFUSCATED-BINARY, INTO A MORE EFFICIENT, ROBUST, AND FORMALLY VERIFIABLE VERSION OF IT. PRISM INCORPORATES DISTRIBUTED COMPILATION TECHNIQUE THAT TACKLES THE
CHALLENGE OF IDENTIFYING, MANAGING, AND COMPILING ENHANCED DSL-CODES FOR A SET OF VARIED TARGET ARCHITECTURES PRODUCING FULLY VERIFIABLE EBPF PROGRAMS. HOWEVER, THE VERIFIED EBPF PROGRAMS NEED TO BE TESTED ACROSS DIVERSE SET OF DOMAINS AND HARDWARE ARCHITECTURES. THERE ARE THREE UNIQUE CHALLENGES: (1) EFFICIENCY: COMPILATION MUST PROCESS LARGE CODEBASES WITH NONTRIVIAL PERFORMANCE GUARANTEES; (2) COMPOSITIONALITY: IT SHOULD CARRY OVER THE COMPOSITIONALITY TO FACILITATE THE FORMAL VERIFICATION; (3) ENHANCEMENTS: THE OUTPUT BINARY SHOULD BE OPTIMIZED (IN TERMS OF CODE SIZE) FOR LATTER TASKS, SUCH AS DEPLOYMENT OR BOTTOM-UP FORMAL VERIFICATION. DISTRIBUTED COMPILATION INTEGRATED IN PRISM WILL PERFORM LINK-TIME OPTIMIZATION BASED ON COMPILATION DISPATCHING GRAPHS. FURTHER, DISTRIBUTED COMPILATION WILL DYNAMICALLY DISPATCH AND OPTIMIZE TRANSFORMED SOFTWARE FOR A SPECIFIC ARCHITECTURE BASED ON THE
OVERLAPPING OF HARDWARE FEATURES. WE WILL PERFORM COMPATIBILITY TESTING ACROSS REAL LIFE DEVICES AND HARDWARE TO ENSURE EFFECTIVENESS AND ACCURACY OF DISTRIBUTED COMPILATION. AWD-002571-S3 Parent award context Parent award agency: Department of Defense · Department of the Navy Parent award NAICS: 541715 Parent award performance state: GA Parent award description: RESEARCH IAW SOW IN SUPPORT OF DARPA V-SPELLS PROGRAM FOR EFFORT TITLED PRISM View parent award on USAspending | — | $477,907 | Oct 4, 2021 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of DefenseGov-sourced
- National Aeronautics and Space AdministrationGov-sourced
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