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IOGENETICS, LLC
MARSHALL, WI, 53559
UnclaimedClaim this profile (free)
Small Business
Subcontracting experience
2 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | IN SUPPORT OF THE MULTI-INSTITUTIONAL EFFORT TO CHARACTERIZE T CELL EPITOPES OF FUNGI, IOGENETICS WILL APPLY ITS EIGENBIO IMMUNOINFORMATICS PLATFORM TO PROVIDE DETAILED EPITOPE MAPS AND RANKINGS. THIS WILL BE DONE IN TWO WAYS.
FIRST A GROUP OF "FAST TRACK" PROTEINS HAS BEEN SELECTED BY THE MYCOLOGISTS IN EACH PARTICIPATING UNIVERSITY . FOR THESE PROTEINS IOGENETICS WILL PROCEED DIRECTLY TO GENERATE DETAILED IMMUNOME MAPS AND TO IDENTIFY PROBABLE T CELL EPITOPES THAT WILL BE RESTRICTED BY MHC II OF THE DR1*0401 ALLELE AS WELL AS FOR A SERIES OF OTHER HUMAN MHC 1 1 ALLELES.
SECONDLY A RATIONAL DOWN SELECTION APPROACH WILL BE USED TO PROVIDE AN UNBIASED APPROACH TO IDENTIFYING OTHER T CELL EPITOPES . THE TOTAL PROTEOME OF EACH OF FOUR FUNGAL SPECIES, BLASTOMYCES DERMATITIDIS, HISTOP/ASMA CAPSULATUM, COCCIDIOIDES POSADASII AND CRYPTOCOCCUS NEOFORMANS WILL BE FILTERED BASED ON EXPRESSION IN ITS PARASITIC PHASE, UPREGULATION AND PRESENCE OF OTHER FEATURES SUCH AS SURFACE EXPOSURE TO IDENTIFY PROTEINS MOST LIKELY TO CARRY RELEVANT T CELL EPITOPES. THE PROTEOMES WILL BE SCREENED TO IDENTIFY IMMUNOSTIMULATORY VS IMMUNOSUPPRESSIVE PROTEINS. BASE DON THIS A SET OF 100-200 PROTEINS WILL BE SELECTED FOR EACH FUNGUS AND SUBJECT TO THE DETAILED MAPPING DESCRIBED FOR THE FAST TRACK GROUP.
IN BOTH CASES THE GOAL IS TO IDENTIFY EXTENDED EPITOPE RICH PEPTIDES WHICH CAN BE EVALUATED AND VALIDATED IN MICE, HUMAN PATIENTS AND IN VITRO.
IOGENETICS EFFORTS WILL BE MOST INTENSE IN THE FIRST TWO YEARS OF THE PROJECT FOLLOWED BY ONGOING ANALYSIS OF RESULTS AND TROUBLE SHOOTING DURING THE OUT YEARS OF THE PROJECT. OSP29546-03 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541512 Parent award performance state: MA Parent award description: LARGE SCALE T CELL EPITOPE DISCOVERY View parent award on USAspending | — | $54,034 | Nov 21, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | IN SUPPORT OF THE MULTI-INSTITUTIONAL EFFORT TO CHARACTERIZE T CELL EPITOPES OF FUNGI, IOGENETICS WILL APPLY ITS EIGENBIO IMMUNOINFORMATICS PLATFORM TO PROVIDE DETAILED EPITOPE MAPS AND RANKINGS. THIS WILL BE DONE IN TWO WAYS.
FIRST A GROUP OF "FAST TRACK" PROTEINS HAS BEEN SELECTED BY THE MYCOLOGISTS IN EACH PARTICIPATING UNIVERSITY . FOR THESE PROTEINS IOGENETICS WILL PROCEED DIRECTLY TO GENERATE DETAILED IMMUNOME MAPS AND TO IDENTIFY PROBABLE T CELL EPITOPES THAT WILL BE RESTRICTED BY MHC II OF THE DR1*0401 ALLELE AS WELL AS FOR A SERIES OF OTHER HUMAN MHC 1 1 ALLELES.
SECONDLY A RATIONAL DOWN SELECTION APPROACH WILL BE USED TO PROVIDE AN UNBIASED APPROACH TO IDENTIFYING OTHER T CELL EPITOPES . THE TOTAL PROTEOME OF EACH OF FOUR FUNGAL SPECIES, BLASTOMYCES DERMATITIDIS, HISTOP/ASMA CAPSULATUM, COCCIDIOIDES POSADASII AND CRYPTOCOCCUS NEOFORMANS WILL BE FILTERED BASED ON EXPRESSION IN ITS PARASITIC PHASE, UPREGULATION AND PRESENCE OF OTHER FEATURES SUCH AS SURFACE EXPOSURE TO IDENTIFY PROTEINS MOST LIKELY TO CARRY RELEVANT T CELL EPITOPES. THE PROTEOMES WILL BE SCREENED TO IDENTIFY IMMUNOSTIMULATORY VS IMMUNOSUPPRESSIVE PROTEINS. BASE DON THIS A SET OF 100-200 PROTEINS WILL BE SELECTED FOR EACH FUNGUS AND SUBJECT TO THE DETAILED MAPPING DESCRIBED FOR THE FAST TRACK GROUP.
IN BOTH CASES THE GOAL IS TO IDENTIFY EXTENDED EPITOPE RICH PEPTIDES WHICH CAN BE EVALUATED AND VALIDATED IN MICE, HUMAN PATIENTS AND IN VITRO.
IOGENETICS EFFORTS WILL BE MOST INTENSE IN THE FIRST TWO YEARS OF THE PROJECT FOLLOWED BY ONGOING ANALYSIS OF RESULTS AND TROUBLE SHOOTING DURING THE OUT YEARS OF THE PROJECT. OSP29546-03 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541512 Parent award performance state: MA Parent award description: LARGE SCALE T CELL EPITOPE DISCOVERY View parent award on USAspending | — | $38,802 | Jan 4, 2023 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.