AGRICULTURAL RESEARCH SERVICE

PEORIA, IL, 61604

Subcontracting experience

4 records from government sources. Past participation is not evidence of current teaming interest.

Role	Agency	Description	Vehicle	Obligated	Action date	Period
Subcontractor	Department of Health and Human Services	RESEARCH SUBCONTRACT ATTACHMENT 4 SUBCONTRACTOR STATEMENT OF WORK AND REPORTING REQUIREMENTS REPORTING - "SERVICE CONTRACT REPORTING REQUIREMENTS" (HTTPS://WWW.ACQUISITION.GOV/ FAR/52.204-14 A) FOR THE PERIOD OF PERFORMANCE 4/01/2026 TO 9/21/2027, THE FOLLOWING INFORMATION MUST BE REPORTED TO THE PRIME AUTHORIZED OFFICIAL BY 10/1/2027. 1) SUBCONTRACTOR NAME 2) SUBCONTRACTOR DUNS NUMBER 3) SUBCONTRACTOR NUMBER, AN 4) SUBCONTRACTOR DIRECT LABOR HOURS THIS INFORMATION WILL BE MADE AVAILABLE TO THE PUBLIC AS REQUIRED BY SECTION 743 OF DIVISION C OF THE CONSOLIDATED APPROPRIATIONS ACT, 2010 NOTE: SEE PRIME AGREEMENT FOR SAMPLE INVOIC THE USDA WILL TRANSPORT COWS FROM PENNSYLVANIA TO IOWA AND THEN CHALLENGE THE ANIMALS WITH H5N1 UNDER BSL3 CONDITIONS. CLINICAL SIGNS, MILK PRODUCTION AND CONSISTENCY, AND OTHER PARAMETERS WILL BE RECORDED AFTER H5N1 CHALLENGE. TISSUE SECTIONS WILL BE MADE AFTER THE ANIMALS ARE EUTHANIZED AT THE END OF THE EXPERIMENT. OVER THE COURSE OF THIS PROJECT, THE USDA WILL COMPLETE 2 OF THESE EXPERIMENTS, WITH 4 ANIMALS PER EACH EXPERIMENT. THE SECOND EXPERIMENT WILL ONLY BE CONDUCTED IF THE 1ST EXPERIMENT IS SUCCESSFUL. 503790 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: PA Parent award description: AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) View parent award on USAspending	—	$33,750	Jul 21, 2026	— – —
Subcontractor	Department of Health and Human Services	STATEMENT OF WORK – PROJECT 3 OBJECTIVES. WE WILL TARGET HUMAN-SWINE INTERFACES IN MAJOR SWINE PRODUCTION REGIONS IN THE US, EUROPE, AND ASIA. COORDINATED SURVEILLANCE WITH SWINE AND HUMAN SAMPLE COLLECTION THAT LEVERAGES EXISTING SURVEILLANCE [E.G., US DEPARTMENT OF AGRICULTURE (USDA) NATIONAL IAV IN SWINE (IAV-S) SURVEILLANCE SYSTEM AND VETERINARY DIAGNOSTIC LABS] WILL ALLOW US TO QUANTIFY DRIVERS OF IAV EVOLUTION IN THE SWINE HOST. OUR OVERALL OBJECTIVE IS TO DEVELOP A RISK FRAMEWORK THAT ARTICULATES HOW ANTIGENIC DIVERSITY AND OTHER PHENOTYPIC PROPERTIES OF CIRCULATING SWINE IAVS AFFECT HUMAN PANDEMIC POTENTIAL AND INTERSPECIES TRANSMISSION. WE WILL DETERMINE THE PUBLIC HEALTH RISK OF CIRCULATING AND EMERGING IAVS IN GLOBAL SWINE POPULATIONS BY A COORDINATED AND SYSTEMATIC PIPELINE OF IN SILICO, IN VITRO, AND IN VIVO TESTING AND ANALYSES. SWINE IAV ISOLATES IDENTIFIED AS UNIQUE THROUGH SURVEILLANCE AND IN VIVO ANALYSES WILL BE CHARACTERIZED BY A IN VIVO AND IN VITRO PANDEMIC POTENTIAL PIPELINE AMONG CEIRR INVESTIGATORS. APPROACH. THIS OBJECTIVE WILL BE ACCOMPLISHED WITH 4 STREAMS OF SWINE VIROLOGIC DATA: 1) ACTIVE SURVEILLANCE IN CAMBODIA; 2) ACTIVE AND PASSIVE SURVEILLANCE IN THE UK; 3) ACTIVE AND PASSIVE SURVEILLANCE IN THE USA; AND 4) LEVERAGING THE USDA SURVEILLANCE SYSTEM AND ESTABLISHED SWINE INFLUENZA NETWORKS. HUMAN SAMPLING WILL OCCUR AT THE SWINE INTERFACE IN CAMBODIA AND THE USA. SEROLOGIC SPECIMENS WILL BE USED FROM OCCUPATIONALLY EXPOSED HUMAN COHORTS TO EVALUATE ANTIBODY RESPONSES TO SWINE IAV AND COMPARE TO URBAN HUMAN COHORTS. SEQUENCE ANALYSIS OF IAV-S WILL BE SUPPORTED BY DEDICATED SWINE COMPUTATIONAL EXPERTISE AND ANTIGENIC AND PHENOTYPIC CHARACTERIZATION OF SWINE IAV FOR ASSESSMENT OF RISK TO HUMANS CONDUCTED IN AND IN VIVO AND IN VITRO PANDEMIC POTENTIAL PIPELINE. EACH OF THESE COMPONENTS WILL CONTRIBUTE TO DEVELOPMENT OF A RISK RANKING METHOD FOR SWINE IAV. METHODS. AIM 1. INVESTIGATE DYNAMICS OF IAV AT HUMAN-SWINE INTERFACES THROUGH: A) LONGITUDINAL SURVEILLANCE FROM RELEVANT SWINE POPULATIONS AND HUMAN-SWINE INTERFACES TO INCLUDE CHARACTERIZATION OF IAV GENETIC DIVERSITY; AND B) COLLECTION OF OCCUPATIONALLY EXPOSED HUMAN COHORT SERA AND VIROLOGIC ASSESSMENT OF INTERSPECIES TRANSMISSION. AIM 2. DEVELOP PHYLOGENETIC ALGORITHMS THAT RAPIDLY IDENTIFY NOVEL REASSORTED VIRUSES, QUANTIFY VIRAL DIVERSITY BETWEEN SWINE AND HUMAN IAV, AND IDENTIFY SWINE IAV STRAINS TO TEST FOR ANTIGENIC ADVANCE OR INCREASED REPLICATION AND TRANSMISSION IN SWINE. AIM 3. ANTIGENIC AND PHENOTYPIC CHARACTERIZATION OF SWINE IAV FOR RISK TO HUMANS BY CHARACTERIZING VIRAL PROPERTIES IN THE SWINE HOST, SWINE-TO-FERRET TRANSMISSION, KEY PREDICTORS OF THE PANDEMIC RISK OF SWINE IAV, AND OTHER DOWNSTREAM MEDIATORS VIA COLLABORATION WITH CEIRR INVESTIGATORS. SCHEDULE. EACH OF THE INVESTIGATORS AND SITE LEADERS IN THIS PROJECT HAVE ESTABLISHED PROGRAMS TO QUICKLY IMPLEMENT SAMPLE FLOW FOR OUR CEIRR PROJECT. CLINICAL SAMPLES FROM LONGITUDINALLY SAMPLED SWINE WILL BE EVALUATED PERIODICALLY THROUGHOUT EACH YEAR, WHEREAS PASSIVE SURVEILLANCE BASED ON ROUTINE SUBMISSIONS TO THE VETERINARY DIAGNOSTIC LABORATORIES PARTICIPATING IN THIS PROPOSAL WILL IMMEDIATELY BEGIN TO ENTER THE PROJECT. VIRAL EVOLUTION AT THE GENETIC AND ANTIGENIC LEVELS WILL BE ASSESSED AT LEAST BI-ANNUALLY TO SELECT STRAINS FOR FURTHER CHARACTERIZATION. AUTOMATED SEQUENCE AND DATA ANALYSIS ALGORITHMS WILL BE DEVELOPED AND IMPLEMENTED TO ASSIST IN THE SELECTION PROCESS. EACH YEAR, SWINE AND FERRET SERA WILL BE RAISED FOR ANTIGENIC CHARACTERIZATION OF UP TO 6 UNIQUE SWINE IAV AND TO TEST AGAINST HUMAN POPULATION SERA, UP TO 3 STRAINS WILL BE ASSESSED FOR PHENOTYPING IN THE SWINE HOST, AND UP TO 2 STRAINS WILL BE ASSESSED FOR AEROSOL TRANSMISSION BETWEEN SWINE AND FERRETS. SWINE IAV RANKED AS HIGHER RISK FOR HUMANS WILL BE SHARED AMONG CEIRR INVESTIGATORS FOR DOWNSTREAM RISK ASSESSMENT STUDIES AND POTENTIAL PUBLIC HEALTH ACTION. 504429 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: PA Parent award description: AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) View parent award on USAspending	—	$530,421	Jun 30, 2026	— – —
Subcontractor	Department of Health and Human Services	STATEMENT OF WORK – PROJECT 3 OBJECTIVES. WE WILL TARGET HUMAN-SWINE INTERFACES IN MAJOR SWINE PRODUCTION REGIONS IN THE US, EUROPE, AND ASIA. COORDINATED SURVEILLANCE WITH SWINE AND HUMAN SAMPLE COLLECTION THAT LEVERAGES EXISTING SURVEILLANCE [E.G., US DEPARTMENT OF AGRICULTURE (USDA) NATIONAL IAV IN SWINE (IAV-S) SURVEILLANCE SYSTEM AND VETERINARY DIAGNOSTIC LABS] WILL ALLOW US TO QUANTIFY DRIVERS OF IAV EVOLUTION IN THE SWINE HOST. OUR OVERALL OBJECTIVE IS TO DEVELOP A RISK FRAMEWORK THAT ARTICULATES HOW ANTIGENIC DIVERSITY AND OTHER PHENOTYPIC PROPERTIES OF CIRCULATING SWINE IAVS AFFECT HUMAN PANDEMIC POTENTIAL AND INTERSPECIES TRANSMISSION. WE WILL DETERMINE THE PUBLIC HEALTH RISK OF CIRCULATING AND EMERGING IAVS IN GLOBAL SWINE POPULATIONS BY A COORDINATED AND SYSTEMATIC PIPELINE OF IN SILICO, IN VITRO, AND IN VIVO TESTING AND ANALYSES. SWINE IAV ISOLATES IDENTIFIED AS UNIQUE THROUGH SURVEILLANCE AND IN VIVO ANALYSES WILL BE CHARACTERIZED BY A IN VIVO AND IN VITRO PANDEMIC POTENTIAL PIPELINE AMONG CEIRR INVESTIGATORS. APPROACH. THIS OBJECTIVE WILL BE ACCOMPLISHED WITH 4 STREAMS OF SWINE VIROLOGIC DATA: 1) ACTIVE SURVEILLANCE IN CAMBODIA; 2) ACTIVE AND PASSIVE SURVEILLANCE IN THE UK; 3) ACTIVE AND PASSIVE SURVEILLANCE IN THE USA; AND 4) LEVERAGING THE USDA SURVEILLANCE SYSTEM AND ESTABLISHED SWINE INFLUENZA NETWORKS. HUMAN SAMPLING WILL OCCUR AT THE SWINE INTERFACE IN CAMBODIA AND THE USA. SEROLOGIC SPECIMENS WILL BE USED FROM OCCUPATIONALLY EXPOSED HUMAN COHORTS TO EVALUATE ANTIBODY RESPONSES TO SWINE IAV AND COMPARE TO URBAN HUMAN COHORTS. SEQUENCE ANALYSIS OF IAV-S WILL BE SUPPORTED BY DEDICATED SWINE COMPUTATIONAL EXPERTISE AND ANTIGENIC AND PHENOTYPIC CHARACTERIZATION OF SWINE IAV FOR ASSESSMENT OF RISK TO HUMANS CONDUCTED IN AND IN VIVO AND IN VITRO PANDEMIC POTENTIAL PIPELINE. EACH OF THESE COMPONENTS WILL CONTRIBUTE TO DEVELOPMENT OF A RISK RANKING METHOD FOR SWINE IAV. METHODS. AIM 1. INVESTIGATE DYNAMICS OF IAV AT HUMAN-SWINE INTERFACES THROUGH: A) LONGITUDINAL SURVEILLANCE FROM RELEVANT SWINE POPULATIONS AND HUMAN-SWINE INTERFACES TO INCLUDE CHARACTERIZATION OF IAV GENETIC DIVERSITY; AND B) COLLECTION OF OCCUPATIONALLY EXPOSED HUMAN COHORT SERA AND VIROLOGIC ASSESSMENT OF INTERSPECIES TRANSMISSION. AIM 2. DEVELOP PHYLOGENETIC ALGORITHMS THAT RAPIDLY IDENTIFY NOVEL REASSORTED VIRUSES, QUANTIFY VIRAL DIVERSITY BETWEEN SWINE AND HUMAN IAV, AND IDENTIFY SWINE IAV STRAINS TO TEST FOR ANTIGENIC ADVANCE OR INCREASED REPLICATION AND TRANSMISSION IN SWINE. AIM 3. ANTIGENIC AND PHENOTYPIC CHARACTERIZATION OF SWINE IAV FOR RISK TO HUMANS BY CHARACTERIZING VIRAL PROPERTIES IN THE SWINE HOST, SWINE-TO-FERRET TRANSMISSION, KEY PREDICTORS OF THE PANDEMIC RISK OF SWINE IAV, AND OTHER DOWNSTREAM MEDIATORS VIA COLLABORATION WITH CEIRR INVESTIGATORS. SCHEDULE. EACH OF THE INVESTIGATORS AND SITE LEADERS IN THIS PROJECT HAVE ESTABLISHED PROGRAMS TO QUICKLY IMPLEMENT SAMPLE FLOW FOR OUR CEIRR PROJECT. CLINICAL SAMPLES FROM LONGITUDINALLY SAMPLED SWINE WILL BE EVALUATED PERIODICALLY THROUGHOUT EACH YEAR, WHEREAS PASSIVE SURVEILLANCE BASED ON ROUTINE SUBMISSIONS TO THE VETERINARY DIAGNOSTIC LABORATORIES PARTICIPATING IN THIS PROPOSAL WILL IMMEDIATELY BEGIN TO ENTER THE PROJECT. VIRAL EVOLUTION AT THE GENETIC AND ANTIGENIC LEVELS WILL BE ASSESSED AT LEAST BI-ANNUALLY TO SELECT STRAINS FOR FURTHER CHARACTERIZATION. AUTOMATED SEQUENCE AND DATA ANALYSIS ALGORITHMS WILL BE DEVELOPED AND IMPLEMENTED TO ASSIST IN THE SELECTION PROCESS. EACH YEAR, SWINE AND FERRET SERA WILL BE RAISED FOR ANTIGENIC CHARACTERIZATION OF UP TO 6 UNIQUE SWINE IAV AND TO TEST AGAINST HUMAN POPULATION SERA, UP TO 3 STRAINS WILL BE ASSESSED FOR PHENOTYPING IN THE SWINE HOST, AND UP TO 2 STRAINS WILL BE ASSESSED FOR AEROSOL TRANSMISSION BETWEEN SWINE AND FERRETS. SWINE IAV RANKED AS HIGHER RISK FOR HUMANS WILL BE SHARED AMONG CEIRR INVESTIGATORS FOR DOWNSTREAM RISK ASSESSMENT STUDIES AND POTENTIAL PUBLIC HEALTH ACTION. 502355 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: PA Parent award description: AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) View parent award on USAspending	—	$528,529	May 9, 2025	— – —
Subcontractor	Department of Health and Human Services	SCOPE OF WORK EVOLUTIONARY ALGORITHMS FOR PRIORITIZING INFLUENZA A VIRUSES FOR PANDEMIC RISK ASSESSMENT PI NAME: TAVIS ANDERSON START/END DATES: SEPTEMBER 2024 – SEPTEMBER 2026 PROJECT DESCRIPTION (INCLUDING OBJECTIVES, TASKS, AND DELIVERABLES AS APPLICABLE): WE WILL DEVELOP AN INTEGRATED COMPUTATIONAL PLATFORM FOR RAPIDLY ASSESSING THE ZOONOTIC AND PANDEMIC POTENTIAL OF A WIDE RANGE OF INFLUENZA A VIRUSES (IAV). THE COMPUTATIONAL PLATFORM WILL RANK THE IAV STRAINS FROM GENOMIC SURVEILLANCE IN NON-HUMAN POPULATIONS BASED ON THEIR ZOONOTIC RISK AND WILL ACCOUNT FOR (I) GENETIC AND ANTIGENIC DIVERSITY, (II) GEOGRAPHIC SPREAD, (III) DETECTION FREQUENCY, (IV) HOST BREADTH, (V) REASSORTMENT HISTORY, AND (VI) PHENOTYPIC PROPERTIES. THE PLATFORM AND DERIVED LISTS OF REPRESENTATIVE VIRUSES AND THEIR PREDICTED PHENOTYPIC PROPERTIES WILL BE AVAILABLE AS A RESOURCE TO ALL CEIRR RESEARCHERS. DELIVERABLES: 1. AN ACCURATE METHOD FOR REASSORTMENT ANALYSIS ON LARGE IAV DATASETS. AS REASSORTMENT PLAYS AN IMPORTANT ROLE IN THE EMERGENCE OF PANDEMIC IAV, WE WILL DEVELOP AND DEPLOY A METHOD FOR AUTOMATIC DETECTION OF REASSORTMENT FROM THE GENOMIC SURVEILLANCE DATA. WE WILL USE THE DETECTED REASSORTMENT EVENTS TO INFORM THE ZOONOTIC RISK ASSESSMENT AND IAV STRAIN RANKING, AND STUDY THE IMPACT OF REASSORTMENT ON PHENOTYPIC EVOLUTION OF IAV. 2. MACHINE LEARNING ALGORITHMS FOR PREDICTING ZOONOSIS-ASSOCIATED PHENOTYPES. A. WE WILL DESIGN EFFECTIVE MACHINE LEARNING MODELS TO PREDICT THE ANTIGENIC NOVELTY OF NON-HUMAN IAV RELATIVE TO THE EXISTING VACCINE AND CANDIDATE VACCINE STRAINS. THE MODELS WILL BE TRAINED ON THE EXISTING HEMAGGLUTININ INHIBITION ASSAY (HI) DATA FOR SWINE AND AVIAN IAV. B. AN INTERPRETABLE MACHINE LEARNING METHOD FOR PREDICTING THE PH STABILITY OF THE IAV HEMAGGLUTININ PROTEIN WILL BE DEVELOPED, LEVERAGING THE PUBLISHED PH STABILITY AND PH OF INACTIVATION ASSAY DATA. 3. AN ALGORITHM FOR SELECTING MOST REPRESENTATIVE SETS OF NON-HUMAN IAV IN TERMS OF GENETIC AND/OR ANTIGENIC DIVERSITY AND RANKING THE REPRESENTATIVE STRAINS BASED ON THE ASSOCIATED ZOONOTIC RISK FACTORS. A. AN EFFICIENT ALGORITHMIC PIPELINE FOR CLUSTERING GENETICALLY AND/OR ANTIGENICALLY SIMILAR IAV WILL BE DEVELOPED WITH MOST REPRESENTATIVE STRAINS BEING SELECTED FROM WITHIN EACH CLUSTER. B. WE WILL DESIGN A ZOONOTIC RISK METRIC THAT INTEGRATES THE PREDICTED PHENOTYPIC PROPERTIES FOR EACH IAV, REASSORTMENT STATUS, DETECTION FREQUENCY, GEOGRAPHIC AND HOST SPREAD. C. A USER-FRIENDLY INTERFACE WILL BE DEVELOPED TO ALLOW RESEARCHERS TO SELECT MOST REPRESENTATIVE IAV STRAINS FOR CONSEQUENT IN VITRO AND IN VIVO STUDIES, AND VIEW THE RISK SCORES OF INDIVIDUAL STRAINS TOGETHER WITH A DETAILED BREAKDOWN OF EACH FACTOR CONTRIBUTING TO THE OVERALL RISK SCORE. 501312 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: PA Parent award description: AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) View parent award on USAspending	—	$391,633	May 7, 2025	— – —

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