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SIMULATIONS PLUS INC
RESEARCH TRIANGLE PARK, NC, 27709
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Other Than Small Business
Prime contracting experience
2 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services Food and Drug Administration | THE OVERARCHING OBJECTIVE IS TO ESTABLISH A QUANTITATIVE IN VITRO IN VIVO EXTRAPOLATION FRAMEWORK CAPABLE OF PREDICTING THE INFLUENCE OF FORMULATION COMPOSITION, DIGESTION BEHAVIOR, CHYLOMICRON BINDING, AND PRANDIAL STATE ON DRUG BIOAVAILABILITY AND | — | $575,554 | Sep 26, 2026 | Sep 30, 2026 – Dec 29, 2027 |
| Prime | Department of Health and Human Services Office of the Assistant Secretary for Financial Resources | GASTROPLUS?, DDDPLUS AND MEMBRANEPLUS SOFTWARE LICENSES | — | $375,965 | Aug 10, 2025 | Aug 31, 2021 – Aug 31, 2026 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
3 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | MR. MULLIN WILL SERVE AS CONSORTIUM PI. HE WILL COORDINATE THE RESEARCH FOR THE MODELING PORTION OF THE PROJECT THAT WILL BE COMPLETED BY SIMULATIONS PLUS, INC. HE WILL BE RESPONSIBLE FOR OVERSEEING THE WORK OF THE SCIENTISTS AND SENIOR SCIENTISTS AT SIMULATIONS PLUS, COMMUNICATING WITH DR. CRISTOFOLETTI TO COORDINATE WORK BETWEEN THE UNIVERSITY OF FLORIDA AND SIMULATIONS PLUS. HE WILL ALSO BE RESPONSIBLE FOR THE TECHNICAL PORTION OF THE ENHANCEMENT OF THE PCAT MODEL STRUCTURE IN THE GASTROPLUS SOFTWARE AND WILL IMPLEMENT COPD AND ASTHMA PHYSIOPATHOLOGIES IN THE SOFTWARE. SUB00003501-01 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541714 Parent award performance state: MD Parent award description: ADVANCING IN VITRO AND (PATHO)PHYSIOLOGY-BASED PHARMACOKINETICS MODELS TO UNDERSTAND AND PREDICT PULMONARY ABSORPTION AND TISSUE RETENTION OF INHALED DRUGS View parent award on USAspending | — | $337,649 | Mar 29, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | MR. MULLIN WILL SERVE AS CONSORTIUM PI. HE WILL COORDINATE THE RESEARCH FOR THE MODELING PORTION OF THE PROJECT THAT WILL BE COMPLETED BY SIMULATIONS PLUS, INC. HE WILL BE RESPONSIBLE FOR OVERSEEING THE WORK OF THE SCIENTISTS AND SENIOR SCIENTISTS AT SIMULATIONS PLUS, COMMUNICATING WITH DR. CRISTOFOLETTI TO COORDINATE WORK BETWEEN THE UNIVERSITY OF FLORIDA AND SIMULATIONS PLUS. HE WILL ALSO BE RESPONSIBLE FOR THE TECHNICAL PORTION OF THE ENHANCEMENT OF THE PCAT MODEL STRUCTURE IN THE GASTROPLUS SOFTWARE AND WILL IMPLEMENT COPD AND ASTHMA PHYSIOPATHOLOGIES IN THE SOFTWARE. SUB00003501 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541714 Parent award performance state: MD Parent award description: ADVANCING IN VITRO AND (PATHO)PHYSIOLOGY-BASED PHARMACOKINETICS MODELS TO UNDERSTAND AND PREDICT PULMONARY ABSORPTION AND TISSUE RETENTION OF INHALED DRUGS View parent award on USAspending | — | $337,650 | May 4, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | ACCORDING TO THE PROPOSAL, THE FOLLOWING WORK WILL BE PERFORMED AT SIMULATIONS PLUS: 1) PRECLINICAL IN VITRO-IN VIVO CORRELATIONS (IVIVC) FOR MEDROXYPROGESTERONE ACETATE LONG-ACTING INJECTABLE SUSPENSIONS (LAIS) WILL BE ESTABLISHED; 2) PREDICTABILITY OF THE ESTABLISHED PRECLINICAL IVIVC MODELS WILL BE PERFORMED AND THE KNOWLEDGE GAPS WILL BE IDENTIFIED; 3) A PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODEL FOR LAIS WILL BE ENHANCED TO ADDRESS LIMITATIONS IDENTIFIED IN THE EARLIER TASKS; 4) THE IN VIVO PERFORMANCE OF NEW FORMULATION VARIANTS OF SELECTED LAI DRUG PRODUCTS WILL BE PREDICTED USING THE ENHANCED PBPK MODEL AND VALIDATED IVIVC. 153085309 Parent award context Parent award agency: Department of Health and Human Services · Food and Drug Administration Parent award NAICS: 541990 Parent award performance state: CT Parent award description: ENHANCEMENT AND VALIDATION OF IN VITRO - IN VIVO CORRELATION METHOD FOR LONG ACTING INJECTABLE DRUG PRODUCTS TO ACCELERATE THEIR GENERIC DEVELOPMENT View parent award on USAspending | — | $238,000 | Feb 9, 2022 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Health and Human ServicesGov-sourced
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.