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MINED XAI LLC
Dayton, OH, 45402
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Subcontracting experience
1 record from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Defense | THE OBJECTIVE OF THIS EFFORT IS TO DEMONSTRATE THE USE OF DEEP TOPOLOGICAL MODELING TO CREATE AN EXPLAINABLE
MACHINE LEARNING SOLUTION FOR ANALYZING MULTI-MODAL DATASETS OBTAINED FROM HUMAN NEUROVASCULAR UNIT-ON-A-CHIP (NVU-OOC) MODELS EXPOSED TO HYPOXIA CONDITIONS. THE NVU-OOC, A TYPE OF MICROPHYSIOLOGICAL
SYSTEM (MPS), MODELS THE BASIC STRUCTURAL AND FUNCTIONAL UNITS, AS WELL AS THE PHYSIOLOGICAL
MICROENVIRONMENT, OF THE HUMAN BRAIN. MPSS ARE COMPOSED OF ONE OR MULTIPLE CELL TYPES OF HUMAN OR
ANIMAL ORIGIN THAT MIMIC THE BIOCHEMICAL, ELECTRICAL, AND MECHANICAL RESPONSES, AS WELL AS CELL BARRIER
PROPERTIES, OBSERVED WITHIN ORGAN SYSTEMS. THESE IN VITRO SYSTEMS EXPEDITE AND ADVANCE SCIENTIFIC
DISCOVERY WITH IMPROVED PREDICTIVE AND TRANSLATIONAL CAPABILITIES, WITHOUT THE USE OF ANIMAL MODELS OR
HUMAN SUBJECTS. MPSS SERVE AS ORGAN SURROGATES TO TEST THE EFFECTS OF VARIOUS STRESSORS/STIMULI (E.G., HEAT
STRESS, HYPOXIA, DRUGS). RESULTS FROM THESE SYSTEMS CAN BE USED TO DEVELOP INTERVENTIONAL AND
COUNTERMEASURE STRATEGIES, AND TAILOR AND SCOPE ADDITIONAL STUDIES USING ANIMAL MODELS OR HUMAN SUBJECTS
IF NEEDED.
MPSS CAN BE CUSTOMIZED TO REFLECT INDIVIDUAL PHYSIOLOGY, SUCH AS THAT OF WARFIGHTERS, BY CREATING ORGANOIDS
DERIVED FROM PLURIPOTENT STEM CELL (IPSC) TECHNOLOGY €€Œ A PATH TOWARDS CREATING HUMAN DIGITAL TWINS. NVUOOCS
ARE SUBJECTED TO DYNAMIC OXYGEN EXPOSURES THAT SIMULATE BRAIN-SPECIFIC HYPOXIA, HYPEROXIA, OR
NORMOXIA CONDITIONS FOR DEFINED TIME PERIODS. VARIOUS DATA TYPES, INCLUDING CELLULAR HEALTH METRICS,
FUNCTIONAL ASSAYS, MULTI-OMICS, AND OTHER METADATA, HAVE BEEN COLLECTED FROM THESE EXPERIMENTS.
OUR DEEP TOPOLOGICAL MODELING CAPABILITIES, WHICH EXTEND DIMENSIONALITY REDUCTION TECHNIQUES AND
METHODS, WILL BE USED TO FORMULATE A ROBUST UNDERSTANDING OF THE MULTIVARIATE SIGNATURES WITHIN THE NVUOOC
DATA. MINED XAI HAS DEVELOPED DEEP TOPOLOGICAL MODELING CAPABILITIES BY EXTENDING DIMENSIONALITY
REDUCTION TECHNIQUES AND METHODS, USING OPEN ARCHITECTURE DESIGN PRINCIPLES TO FORMULATE A ROBUST
UNDERSTANDING OF COMPLEX SIGNALS, WHICH CAN BE GENERALIZED ACROSS DOMAINS. WE HAVE FURTHER
REVOLUTIONIZED AND MATURED DEEP TOPOLOGICAL MODELING TO PROVIDE A FULLY EXPLAINABLE EXPLOITATION TOOL
WHEREBY MODELS THROUGHOUT THE ARCHITECTURE CAN BE ANALYZED EITHER IN COMPONENT OR IN AGGREGATE. OUR XAI
MODELS CAPTURE THE COMPLEX MULTIVARIATE SIGNATURES PRESENT IN BIOLOGICAL SYSTEMS AND PROVIDE A
COMPREHENSIVE VIEW OF THE UNDERLYING DATA, ENABLING A DEEPER UNDERSTANDING OF THE INTRICATE BIOLOGICAL
PROCESSES OCCURRING WITHIN THE NVU-OOC MODELS.
NVU-OOC GENERATE MULTI-MODAL DATA FROM VARIOUS BIOLOGICAL, PHYSIOLOGICAL, AND MECHANICAL
MEASUREMENTS CONDUCTED VIA A SET OF TIME SERIES EXPERIMENTS. ANALYZING MULTIVARIATE DATA OBTAINED FROM
NVU-OOC WITH EXPLAINABILITY CAN BE CHALLENGING TO INTEGRATE AND INTERPRET. THE APPLICATION OF XAI,
SPECIFICALLY THROUGH OUR HIERARCHICAL DEEP TOPOLOGICAL DATA MODELING, OFFERS A POWERFUL TOOL FOR ANALYZING
MULTI-MODAL DATA FROM NVUOOC. BY PROVIDING SCALABILITY, EXPLAINABILITY, AND COMPREHENSIVE MULTIVARIATE
ANALYSIS, THIS APPROACH WILL ENHANCE THE UNDERSTANDING OF COMPLEX BIOLOGICAL NETWORKS, ULTIMATELY LEADING TO
MORE INFORMED AND RELIABLE SCIENTIFIC CONCLUSIONS. S-168-61Q-001 Parent award context Parent award agency: Department of Defense · Department of the Air Force Parent award NAICS: 541715 Parent award performance state: OH Parent award description: BIOTECHNOLOGY FOR HUMAN HEALTH AND PERFORMANCE View parent award on USAspending | FA865019D6109USAspending | $129,400 | Aug 22, 2024 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.