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ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM (ERASMUS MC)
Doing business as ERASMUS MC
ROTTERDAM, 3015G
UnclaimedClaim this profile (free)
Subcontracting experience
6 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | LOCAL AND SYSTEMIC T-CELL RESPONSES TO HERPES SIMPLEX VIRUS. UWSC11437 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541512 Parent award performance state: WA Parent award description: LARGE SCALE T CELL EPITOPE DISCOVERY View parent award on USAspending | — | $163,474 | Aug 22, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | OPTION 16D: 0258-A740-4612
IN THIS PROJECT, WE WILL STUDY NON-HOMOLOGOUS RECOMBINATION (NHR) IN THE CONTEXT OF THE ACQUISITION OF A MULTI-BASIC CLEAVAGE SITE IN THE HEMAGGLUTININ OF H7 AVIAN INFLUENZA VIRUSES. WE WILL INVESTIGATE THE POTENTIAL INVOLVEMENT OF SMALL NUCLEOLAR RNAS AND OTHER POTENTIAL VIRAL AND HOST FACTORS IN NHR USING VIRAL RIBONUCLEOPROTEINS RECONSTITUTIONS IN CELLS AND REPLICATION-DEFICIENT VIRUSES.
OPTION 14A: IF300302084-940003
IN THIS PROJECT, WE WILL PERFORM A PRE-CLINICAL STUDY IN FERRETS TO ASSESS THE IMMUNOGENICITY AND PROTECTION OF H5 MRNA VACCINES. TWO ANTIGENS WILL BE COMPARED: OUR RECENTLY DESIGNED ANTIGENICALLY CENTRAL (AC) ANHUI ANTIGEN AND A/ASTRAKHAN/3212/2020, ANTIGEN FROM THE SEQIRIUS VACCINE. HOMOLOGOUS PRIME-BOOST AND HETEROLOGOUS PRIME-BOOST REGIMENS (AC-ANHUI PRIME AND ASTRAKHAN BOOST AND VICE-VERSA) WILL BE COMPARED. H5 SPECIFIC T-CELL WILL BE MEASURED AND ANTIBODY LANSDCAPES SHOWING THE BREADTH OF SERA REACTIVITY AGAINST OVER 100 H5 ANTIGENS WILL BE BUILT. FERRETS WILL BE CHALLENGED WITH HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS FROM THE ONGOING US CATTLE OUTBREAK.
OPTION 12C: IF300302132-940003
THE OVERALL OBJECTIVE OF THIS PROJECT IS TO PERFORM A BROAD AND IN-DEPTH CHARACTERIZATION OF INFLUENZA VIRUS-SPECIFIC IMMUNE RESPONSES USING DOWNSTREAM SEROLOGICAL, B- AND T-CELL ANALYSES OF SAMPLES COLLECTED PRE- AND POST-VACCINATION DURING AN NIH SPONSORED CLINICAL TRIAL ASSESSING A ANTIGENICALLY CENTRAL H5 VACCINE IN HUMANS. 0258-A740-4612 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: NY Parent award description: MSSM CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE. View parent award on USAspending | — | $1,495,650 | Mar 18, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | PROF. DIMITRIS RIZOPOULOS WILL SERVE AS A PI THROUGH A MULTIPLE PI MECHANISM ON THE €œMODELING THE OUTCOMES OF RECLASSIFYING LOW-GRADE PROSTATE CANCER AS NON-CANCER" CDC SOLICITATION 75D301-22-R-72219.
PROF. RIZOPOULOS WILL SUPERVISE THE WORK BEING PERFORMED AT THE ERASMUS MC, SPECIFICALLY THE MODELING WORK AND SOFTWARE DEVELOPMENT. PROF. RIZOPOULOS WILL SUPERVISE THE RESEARCH TEAM, INCLUDING POSTDOCTORAL FELLOW. PROF. RIZOPOULOS AND THE RESEARCH TEAM WILL PARTICIPATE IN MONTHLY CONFERENCE CALLS AND TWICE YEARLY IN-PERSON MEETINGS. PROF. RIZOPOULOS AND THE RESEARCH TEAM WILL PARTICIPATE AS (CO-) AUTHORS ON JOINT MANUSCRIPTS AND
REPORTS. 0001133312 Parent award context Parent award agency: Department of Health and Human Services · Centers for Disease Control and Prevention Parent award NAICS: 541714 Parent award performance state: WA Parent award description: CONSULTATION AND CANCER RESEARCH SERVICES View parent award on USAspending | — | $162,346 | Feb 14, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | LOCAL AND SYSTEMIC T-CELL RESPONSES TO HERPES SIMPLEX VIRUS. UWSC11437 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541512 Parent award performance state: WA Parent award description: LARGE SCALE T CELL EPITOPE DISCOVERY View parent award on USAspending | — | $162,648 | Nov 29, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | BASE: 0258-A504-4612
OPTION 1: 0258-B504-4612
OPTION 2: 0258-C504-4612
OPTION 3: 0258-D504-4612
OPTION 4: IF300302118-940003
OPTION 5: IF300302188-940003
ERASMUS MEDICAL CENTER, LED BY DR. RON FOUCHIER, WILL PARTICIPATE IN ACTIVITIES OF RISK ASSESSMENT AND THE RESPONSE DURING A POTENTIAL PANDEMIC AS WELL AS BASIC RESEARCH ON PATHOGENESIS AND THE IMMUNE RESPONSE FOR THE PROJECT, “MOLECULAR DETERMINANTS OF VIRAL EMERGENCE, VIRULENCE, EVOLUTION AND TRANSMISSION."
OPTION 18B: 0258-A706-4612
ERASMUS MC WILL PERFORM BIO-INFORMATICS WITH THE UNIVERSITY OF CAMBRIDGE (DEREK SMITH ET AL, CRIP) IN THE CONTEXT OF THE EARLY DETECTION AND ANALYSIS SAVE, INCLUDING ANALYSES OF GENETIC AND ANTIGENIC DATA. THROUGH CLONING, VSV BASED VLPS WILL BE GENERATED AND S1 PROTEINS EXPRESSED FOR SOLID PHASE ASSAYS. ERASMUS MC WILL PROVIDE REAGENTS BY GENERATING 40 POST-INFECTION HAMSTER SERA TO 10 VIRUS VARIANTS (10 GROUPS OF 4 HAMSTERS). THESE SERA WILL BE TESTED IN CROSSNEUTRALIZATION WITH 10 VIRUS VARIANTS. WE WILL PERFORM SIDE-BY SIDE COMPARISONS OF VARIOUS SEROLOGY TESTS (E.G. CLASSICAL VIRUS NEUTRALIZATION, VLP-ASSAY, SOLID PHASE ASSAY). WE WILL FURTHER PERFORM SIDE-BY-SIDE COMPARISON OF DATASETS GENERATED WITH VARIOUS SERUM COLLECTIONS (E.G. HAMSTERS FROM EMC, FERRETS FROM RICHARD WEBBY AT ST JUDE CEIRR, HUMAN SERA). ADDITIONAL (FUTURE) NEWLY EMERGING VARIANTS WILL BE CHARACTERIZED WITH THE SERA COLLECTED FROM THE 10 GROUPS OF HAMSTERS. DATA WILL BE ANALYZED USING ANTIGENIC CARTOGRAPHY, IN COLLABORATION WITH UNIVERSITY OF CAMBRIDGE. ANTIGENIC MAPS GENERATED WITH THE VARIOUS SERUM SOURCES AND THE VARIOUS SEROLOGY ASSAYS WILL BE COMPARED TO INVESTIGATE WHICH METHODS AND ANIMAL MODELS MOST CLOSELY REFLECT RELEVANT ANTIGENIC DATA FROM HUMANS.
OPTION 9A: 0258-A709-4612
PREVIOUSLY, IN OPTION 18B WE OBTAINED HIGH TITER HAMSTER SERA AGAINST 10 SARS-COV-2 VARIANTS (B1; B1.1.7; B.1.1.28 P1; B.1.351; B.1.28 P2; B.1.621; B.1.617; B.1.22 MINK; B.1.8 MINK; B.11 MINK). CROSS SEROLOGY STUDIES WITH THESE DIFFERENT VARIANTS AND THE HAMSTER SERA (FOUR PER VARIANT) USING CLASSICAL VIRUS NEUTRALIZATION ASSAYS WITH EITHER VIRUS ISOLATES OR PSEUDOTYPED VIRUSES WERE PERFORMED. THE OUTPUT GENERATED WAS USED TO CONSTRUCT AN ANTIGENIC MAP AND COMPARED TO HUMAN DATA. BASICALLY, ANTIGENIC DIFFERENCES OBSERVED USING HAMSTER SERA WERE VERY SIMILAR TO DATA OBTAINED USING HUMAN SERA (HTTPS://DOI.ORG/10.1126/SCIIMMUNOL.ABQ4450).
NOVEL SARS-COV-2 VARIANTS ARE EMERGING BUT WE ONLY PLANNED TO STUDY 10 VARIANTS IN THE FIRST PROJECT (OPTION 18B). BECAUSE MONOSPECIFIC HUMAN SERA WILL BE MORE DIFFICULT TO OBTAIN, ANIMAL SERA MAY FILL THIS GAP. THE CURRENT PROPOSAL WILL ALLOW THE INCLUSION OF ANOTHER 10 VARIANTS, STUDY ALTERNATIVE METHODS TO GENERATE SERA USING PSEUDOTYPED VIRUSES, AND TO PERFORM A MORE IN-DEPTH ANALYSIS OF THE MOLECULAR BASIS OF THE ANTIGENIC DIFFERENCES OBSERVED AS WELL AS A MORE COMPREHENSIVE COMPARISON WITH HUMAN SERA. 0258-A504-4612 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: NY Parent award description: MSSM CEIRR - THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE. View parent award on USAspending | — | $1,802,869 | Mar 31, 2022 | — – — |
| Subcontractor | Department of Health and Human Services | LOCAL AND SYSTEMIC T-CELL RESPONSES TO HERPES SIMPLEX VIRUS. UWSC11437 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541512 Parent award performance state: WA Parent award description: LARGE SCALE T CELL EPITOPE DISCOVERY View parent award on USAspending | — | $163,198 | Oct 26, 2021 | — – — |
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