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KINVARD BIO, INC.
FLOURTOWN, PA, 19031
UnclaimedClaim this profile (free)
Subcontracting experience
1 record from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | KINVARD BIO AIMS TO BUILD UPON RESEARCH FROM THE LABORATORY OF PR. ANDY MYERS AT HARVARD UNIVERSITY WHICH HAS DELIVERED A HIGHLY PROMISING SERIES OF NEXT GENERATION LINCOSAMIDE ANTIBIOTICS, COLLECTIVELY TERMED THE OXEPANOPROLINAMIDES (OPPS). THIS RESEARCH UTILIZED CHEMICAL SYNTHESIS TO ACCESS LINCOSAMIDE ANALOGS WITH SIGNIFICANT SCAFFOLD MODIFICATIONS INACCESSIBLE BY SEMI-SYNTHETIC METHODS. THIS EFFORT SUCCESSFULLY DELIVERED LEAD COMPOUNDS THAT ARE HIGHLY ACTIVE IN BACTERIA EXPRESSING DIVERSE RESISTANCE MECHANISMS WHICH RENDER CLINDAMYCIN (AND OTHER RIBOSOME TARGETING ANTIBIOTICS) INEFFECTIVE. INFORMED BY THE DATA GENERATED BY THE PREVIOUS COLLABORATION BETWEEN CARB-X AND THE MYERS LAB AT HARVARD, OUR CURRENT PROGRAM AIMS TO FURTHER PROFILE THE MOST PROMISING LEAD COMPOUND WHILE CONDUCTING A FOCUSED LEAD OPTIMIZATION (LO) CAMPAIGN. WE WILL CHARACTERIZE KEY FEATURES OF THE OPP CLASS AND DEVELOP TOOLS TO MOST EFFECTIVELY EXECUTE THE LO EFFORT. THE LO PROGRAM AIMS TO PRODUCE NEW OPPS WITH INCREASED CHEMICAL DIVERSITY AND ENHANCED ANTIBACTERIAL ACTIVITY WHILE MAINTAINING THE FAVORABLE ATTRIBUTES OF THE CLASS. ULTIMATELY, THESE ACTIVITIES SEEK TO DELIVER A DEVELOPMENT CANDIDATE TO ADDRESS THE NEED FOR NEW ORAL THERAPIES IN THE TREATMENT OF COMMUNITY ACQUIRED BACTERIAL PNEUMONIA (CABP) AND ACUTE SKIN AND SKIN STRUCTURE INFECTIONS (ABSSSI). KC4078 Parent award context Parent award agency: Department of Health and Human Services · Office of Assistant Secretary for Preparedness and Response Parent award NAICS: 541714 Parent award performance state: MA Parent award description: CARB-X GLOBAL ANTIBACTERIAL ACCELERATOR OTA View parent award on USAspending | — | $452,265 | Jul 11, 2025 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
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