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SCRIPPS RESEARCH INSTITUTE
Doing business as THE SCRIPPS RESEARCH INSTITUTE, INC
LA JOLLA, CA, 92037
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Other Than Small Business
Prime contracting experience
2 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Prime | Department of Health and Human Services National Institutes of Health | RATIONAL SYSTEMIC CHARACTERIZATION AND SELECTION OF ADJUVANTS FOR HIV VACCINE CANDIDATES (R-CASA) | — | $5,802,669 | Jul 29, 2026 | Aug 1, 2024 – Jul 31, 2027 |
| Prime | Department of Health and Human Services Centers for Disease Control and Prevention | SCRIPPS BAA - TOPIC 7 - GENOMIC SEQUENCING OF SARS-COV-2 | — | $2,545,376 | Sep 6, 2022 | Sep 14, 2022 – Sep 13, 2024 |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Subcontracting experience
9 records from government sources. Past participation is not evidence of current teaming interest.
| Role | Agency | Description | Vehicle | Obligated | Action date | Period |
|---|---|---|---|---|---|---|
| Subcontractor | Department of Health and Human Services | IN THIS PROJECT, WE WILL STRUCTURALLY AND BIOPHYSICALLY CHARACTERIZE NEUTRALIZING ANTIBODIES AND
IMMUNE SERA DERIVED FROM NATURAL INFECTION BY INFLUENZA VIRUS AND FROM VACCINATION. THE WILSON
LAB WILL EXPRESS AND PURIFY ANTIBODIES, ANTIGENS AND IMMUNOGENS FROM MAMMALIAN CELL LINES,
INCLUDING 293S, 293T AND 293F CELLS, DROSOPHILA CELLS, OR E. COLI FOR STRUCTURAL AND BIOPHYSICAL
STUDIES. WE WILL THEN STRUCTURALLY AND BIOPHYSICALLY ANALYZE THESE NEUTRALIZING ANTIBODIES WITH
INFLUENZA ANTIGENS [HEMAGGLUTININ (HA), AND NEURAMINIDASE (NA)], AS WELL AS IDENTIFIED RESISTANCE MUTANTS, TO DETERMINE ANTIBODY AFFINITIES AND MODE OF BINDING, STABILITY, STOICHIOMETRY, EPITOPES AND 3D STRUCTURES. WE WILL USE X-RAY CRYSTALLOGRAPHY TO DETERMINE THE HIGH-RESOLUTION STRUCTURES OF ANTIBODIES AND ANTIBODY-ANTIGEN COMPLEXES. OTHER BIOPHYSICAL METHODS INCLUDING BIO-LAYER INTERFEROMETRY (BLI), ISOTHERMAL TITRATION CALORIMETRY ITC), DIFFERENTIAL SCANNING CALORIMETRY (DSC) AND SURFACE PLASMON RESONANCE (SPR), WILL BE USED TO DETERMINE BINDING AFFINITIES AND PROTEIN/IMMUNOGEN STABILITY. WE WILL DESIGN, MODIFY AND CHARACTERIZE IMMUNOGENS AS VACCINES CANDIDATES USING STRUCTURE-ASSISTED VACCINE DESIGN METHODS THAT WE HAVE PREVIOUSLY SUCCESSFULLY UTILIZED FOR HIV, INFLUENZA VIRUS AND HEPATITIS C VIRUS. THE WARD LAB WILL UTILIZE THEIR RECENTLY DEVELOPED NOVEL EM IMAGING METHOD OF POLYCLONAL EPITOPE MAPPING (EMPEM) TO ANALYZE POLYCLONAL ANTIBODY RESPONSES IN SERA TO IDENTIFY PATTERNS OF EPITOPE UTILIZATION AND FREQUENCY IN HA AND NA IN HUMAN LONGITUDINAL COHORTS. THE HA OR NA PROTEIN PROBES IN THESE ANALYSES WILL BE PRODUCED IN THE WILSON LAB AND SERA PROVIDED BY OUR COLLEAGUES IN THIS CEIRR PROJECT. 504429 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: PA Parent award description: AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) View parent award on USAspending | — | $463,121 | Apr 6, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | INNOVATIONS IN FUNCTIONAL B-CELL EPITOPE DISCOVERY IN FOOD ALLERGENS 63707761-317091 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: CA Parent award description: INNOVATIONS IN FUNCTIONAL B CELL EPITOPE DISCOVERY View parent award on USAspending | — | $201,348 | Jan 16, 2026 | — – — |
| Subcontractor | Department of Health and Human Services | INNOVATIONS IN FUNCTIONAL B-CELL EPITOPE DISCOVERY IN FOOD ALLERGENS 63707761-317091 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541714 Parent award performance state: CA Parent award description: INNOVATIONS IN FUNCTIONAL B CELL EPITOPE DISCOVERY View parent award on USAspending | — | $246,525 | May 19, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | STATEMENT OF WORK FOR WILSON AND WARD LABS
IN THIS PROJECT, WE WILL STRUCTURALLY AND BIOPHYSICALLY CHARACTERIZE NEUTRALIZING ANTIBODIES AND
IMMUNE SERA DERIVED FROM NATURAL INFECTION BY INFLUENZA VIRUS AND FROM VACCINATION. THE WILSON
LAB WILL EXPRESS AND PURIFY ANTIBODIES, ANTIGENS AND IMMUNOGENS FROM MAMMALIAN CELL LINES,
INCLUDING 293S, 293T AND 293F CELLS, DROSOPHILA CELLS, OR E. COLI FOR STRUCTURAL AND BIOPHYSICAL
STUDIES. WE WILL THEN STRUCTURALLY AND BIOPHYSICALLY ANALYZE THESE NEUTRALIZING ANTIBODIES WITH
INFLUENZA ANTIGENS [HEMAGGLUTININ (HA), AND NEURAMINIDASE (NA)], AS WELL AS IDENTIFIED RESISTANCE
MUTANTS, TO DETERMINE ANTIBODY AFFINITIES AND MODE OF BINDING, STABILITY, STOICHIOMETRY, EPITOPES
AND 3D STRUCTURES. WE WILL USE X-RAY CRYSTALLOGRAPHY TO DETERMINE THE HIGH-RESOLUTION STRUCTURES
OF ANTIBODIES AND ANTIBODY-ANTIGEN COMPLEXES. OTHER BIOPHYSICAL METHODS INCLUDING BIO-LAYER
INTERFEROMETRY (BLI), ISOTHERMAL TITRATION CALORIMETRY ITC), DIFFERENTIAL SCANNING CALORIMETRY
(DSC) AND SURFACE PLASMON RESONANCE (SPR), WILL BE USED TO DETERMINE BINDING AFFINITIES AND
PROTEIN/IMMUNOGEN STABILITY. WE WILL DESIGN, MODIFY AND CHARACTERIZE IMMUNOGENS AS VACCINES
CANDIDATES USING STRUCTURE-ASSISTED VACCINE DESIGN METHODS THAT WE HAVE PREVIOUSLY SUCCESSFULLY
UTILIZED FOR HIV, INFLUENZA VIRUS AND HEPATITIS C VIRUS. THE WARD LAB WILL UTILIZE THEIR RECENTLY
DEVELOPED NOVEL EM IMAGING METHOD OF POLYCLONAL EPITOPE MAPPING (EMPEM) TO ANALYZE
POLYCLONAL ANTIBODY RESPONSES IN SERA TO IDENTIFY PATTERNS OF EPITOPE UTILIZATION AND FREQUENCY IN
HA AND NA IN HUMAN LONGITUDINAL COHORTS. THE HA OR NA PROTEIN PROBES IN THESE ANALYSES WILL BE
PRODUCED IN THE WILSON LAB AND SERA PROVIDED BY OUR COLLEAGUES IN THIS CEIRR PROJECT. 502355 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: PA Parent award description: AWARD OF THE BASE TO UPENN FOR CEIRR CONTRACT 75N93021C00015. THIS CONTRACT WILL SUPPORT THE NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE (CEIRR) View parent award on USAspending | — | $449,625 | Apr 8, 2025 | — – — |
| Subcontractor | Department of Health and Human Services | THE SUBCONTRACTOR LAB WILL HELP COLLEAGUES WITH THE PRODUCTION, PURIFICATION, AND CHARACTERIZATION OF THE
IMMUNOGENS FOR THE STUDY, INCLUDING THE REAGENTS NEEDED FOR ELISA AND BIOLAYER INTERFEROMETRY ASSAYS
(BLI) TO ASSESS ANTIBODY AFFINITY, AND VIRUSES TO BE TESTED FOR TZM-BL HIV-1 NEUTRALIZATION ASSAY. WE WILL
ALSO PROVIDE THE REAGENTS AND SUPPLIES NEEDED FOR ANTIGEN SPECIFIC B CELL SORTING TO OBTAIN AND GENERATE
ENV-SPECIFIC B CELL CLONES AND WITH A FOCUS ON IDENTIFYING CLONES TARGETING ENV FUSION PEPTIDE. WE WILL SCREEN ANIMALS FOR VIRUS SPECIFIC RESPONSES AND ASSESS BINDING SITES TO ASSESS SPECIFICITY AND BREADTH OF PROTECTION TUL-HSC-562900-24/25 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: LA Parent award description: CONDUCT STUDY 222 View parent award on USAspending | 75N93020D00007USAspending | $687,504 | Oct 22, 2024 | — – — |
| Subcontractor | Department of Health and Human Services | OPT1 ADDL SETS-SUBK 23X061F1 Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: MD Parent award description: NIAID RESEARCH DATA ECOSYSTEM FRAMEWORK (NIDEF) View parent award on USAspending | 75N91019D00024USAspending | $5,007,134 | May 1, 2023 | — – — |
| Subcontractor | Department of Defense | PROCURED GOODS AND/OR SERVICES BETWEEN 01-APR-23 AND 30-APR-23 IN SUPPORT OF CONTRACT SOW. P010285364-0 Parent award context Parent award agency: Department of Defense · Department of the Army Parent award NAICS: 541715 Parent award performance state: CA Parent award description: PHASE 1: BASE PERIOD_ View parent award on USAspending | — | $1,759,943 | Apr 3, 2023 | — – — |
| Subcontractor | Department of Defense | PROCURED GOODS AND/OR SERVICES BETWEEN 01-MAR-23 AND 31-MAR-23 IN SUPPORT OF CONTRACT SOW. P010285364-0 Parent award context Parent award agency: Department of Defense · Department of the Army Parent award NAICS: 541715 Parent award performance state: CA Parent award description: PHASE 1: BASE PERIOD_ View parent award on USAspending | — | $100,000 | Mar 27, 2023 | — – — |
| Subcontractor | Department of Health and Human Services | KYLIE KONRATH WILL VISIT THE WARD LAB FOR THE PURPOSE OF LEARNING OUR EMPEM PIPELINE FOR MAPPING THE EPITOPES OF POLYCLONAL ANTIBODIES ON VIRAL ANTIGENS. SHE WILL LEARN HOW TO PREP SERUM, PURIFY IGG, DIGEST INTO FAB, AND MAKE IMMUNE COMPLEXES. SHE WILL ALSO LEARN HOW TO PREPARE SAMPLES FOR IMAGING IN THE ELECTRON MICROSCOPE AND COLLECT DATA. THESE DATA WILL THEN BE PROCESSED USING 2D AND 3D CLASSIFICATION TO GENERATE 3D MAPS OF THE IMMUNE COMPLEXES WHICH CAN BE USED TO INTERPRET THE IMMUNOGENIC SURFACE OF INFLUENZA ANTIGENS THAT ARE TARGETED AFTER VACCINATION WITH IMMUNOGENS DESIGNED IN THE KULP LAB. 0258-A460-4609 (DR. WARD) Parent award context Parent award agency: Department of Health and Human Services · National Institutes of Health Parent award NAICS: 541715 Parent award performance state: NY Parent award description: THIS CONTRACT WILL SUPPORT COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES, BASED ON PRINCIPLES OF INFLUENZA IMMUNITY, THAT ACHIEVE DURABLE, ROBUST View parent award on USAspending | — | $14,272 | Sep 6, 2022 | — – — |
Contract vehicles are shown only when present in the source record. Linked award numbers and vehicles open the authoritative record on USAspending.gov.
Agencies supported
- Department of Health and Human ServicesGov-sourced
Government-sourced data comes from SAM.gov, SBA and USAspending.gov and is attributed to its source. Items marked company-reported were provided by the company and are verified by FedSub only where labeled. FedSub is a private company and is not affiliated with SBA, GSA/SAM.gov, or any government agency.