Opportunities
SolicitationAmended Oct 28, 2026Accepting responses

High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

Defense Advanced Research Projects Agency · DEF ADVANCED RESEARCH PROJECTS AGCY

Respond by: Nov 5, 2026, 3:00 PM (time zone not stated)6 days left

Time zone not stated; FedSub reads it as Eastern time.

From SAM.gov's public data file generated Oct 29, 2026, 3:30 AM UTC; newest notice posted Oct 29, 2026; loaded into FedSub Oct 29, 2026, 5:46 AM UTC

Notice facts

Source: SAM.gov Contract Opportunities public data file

Solicitation number
DARPA-PA-27-01
Notice type
Solicitation
Posted
Oct 8, 2026 · Amended Oct 28, 2026
Response date
Respond by Nov 5, 2026, 3:00 PM (time zone not stated)Time zone not stated; FedSub reads it as Eastern time.
Set-aside
None stated
NAICS code
541714 Research and Development in Biotechnology (except Nanobiotechnology)
Product or service code
AC12
Place of performance
Not stated
Contracting office
DEF ADVANCED RESEARCH PROJECTS AGCY (HR0011)ARLINGTON, VA 22203
Agency
Department of Defense · Defense Advanced Research Projects Agency

Past prime awardees

Source: Award history, not a list of bidders on this notice

Past prime awardees · award history, not a list of bidders on this notice

52 companies held prime contracts from this office under NAICS 541714; 29 of them reported first-tier subawards to companies with NAICS 541714 in FedSub's records.

24 more past prime awardees on Professional

Description

Source: SAM.gov Contract Opportunities public data file

UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

SAM.gov's data file removes line breaks; read the formatted notice and attachments on SAM.gov.

Versions on SAM.gov

Source: SAM.gov Contract Opportunities public data file

  1. Posted Oct 28, 2026SolicitationCurrent version

    Respond by Nov 5, 2026, 3:00 PM (time zone not stated)

    Changed from the version before: Description

    This version on SAM.gov (opens SAM.gov in a new tab)
  2. Posted Oct 8, 2026Solicitation

    Respond by Nov 5, 2026, 3:00 PM (time zone not stated)

    This version on SAM.gov (opens SAM.gov in a new tab)

Sources

  • SAM.gov Contract Opportunities public data file: file generated Oct 29, 2026, 3:30 AM UTC
  • USAspending.gov prime contract awards, as loaded into FedSub: actions through Oct 25, 2026
  • USAspending.gov first-tier subaward reports (FFATA): reports through Sep 30, 2026
  • Your partner preferences and your company's records on FedSub

Notices posted or changed after SAM.gov generated its file appear in FedSub after the next load. Check SAM.gov for the current version before you respond.

Source: SAM.gov Contract Opportunities public data file. FedSub is not affiliated with SAM.gov or GSA.

High-throughput Unmasking of Biological Interactomes with Binding… | FedSub